Searchable abstracts of presentations at key conferences in endocrinology
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10th European Congress of Endocrinology

Poster Presentations

Bone and calcium

ea0016p62 | Bone and calcium | ECE2008

Recognition of osteoporosis and analysis of influencing factors

Park Jinho , Cho Belong , Kwon Hyuktae

Backgrounds: As the average lifespan in human increases, osteoporosis and osteoporosis-related fractures have been major health care problems. Despite recent advances in medical treatment, few studies have assessed the recognition of osteoporosis by general adults. This study examined the recognition of osteoporsosis and analysed the relating factors.Methods: We made one to one questions in a rural area called chunjunlee in chunchon city. The questionnai...

ea0016p63 | Bone and calcium | ECE2008

Comparison of ultrasonography and 99mtechnetium sestamibi in localization of parathyroid adenoma in primary hyperparathyroidism

Nasiri Shirzad , Sourush Ahmad Reza , Hashemi Amir Pejman , Hedayat Anushiravan

Aims: Determine the utility of ultrasonography for the preoperative localization of enlarged parathyroid glands in primary hyperparathyroidism and to compare this method with 99mtechnetium sestamibi scintigraphy.Methods: The results of ultrasonographic localization of enlarged parathyroid glands witch were performed by one experienced ultrasonographer were determined in 65 consecutive patients with primary hyperparathyroidism and compared with...

ea0016p64 | Bone and calcium | ECE2008

Daidzein unlike other isolated isoflavones, preserves bone architecture in ovariectomized female rats in vivo

Somjen Dalia , Katzburg Sara , Kohen Fortune , Gayer Batya , Livne Erella

Ovariectomy of immature female rats, results in significant decrease of trabecular bone volume and in cortical bone thickness. Previously we found that estradiol-17β (E2) restored bone structure of ovariectomized female rats (Ovx) to values obtained in intact sham-operated female rats. E2 also selectively stimulated creatine kinase specific activity (CK) a hormonal-genomic activity marker. In the present study, we compared the effects of E2</sub...

ea0016p65 | Bone and calcium | ECE2008

Surgical management of renal hyperparathyroidism: a preliminary series report

Radu Diaconescu Mihai , Ioan Costea , Mihai Glod , Mirela Grigorovici , Adrian Covic

Background: Renal hyperparathyroidism (RHPT) is a frequent complication of uremic patients on hemodialysis and despite various advances in medical therapy parathyroidectomy is necessary in a semnificative number of cases.Patients and methods: We reviewed our experience (first in Romania) regarding thirtyfour patients with RHPT operated on in our clinic between 1994 and 2007 evaluating the diagnosis methods, surgical indications, techniques and results to...

ea0016p66 | Bone and calcium | ECE2008

Osteopenia/osteoporosis in adult thalassemic patients: contribution of growth hormone - insulin-like growth factor I deficiency

Scacchi Massimo , Danesi Leila , Cattaneo Agnese , Valassi Elena , Pecori Giraldi Francesca , Argento Crocetta , D'Angelo Emanuela , Mirra Nadia , Zanaboni Laura , Tampieri Benedetta , Cappellini Maria Domenica , Cavagnini Francesco

GH and IGF-I exert an important role in the control of bone formation. Osteopenia and osteoporosis are a frequent recurrence in patients with thalassemia. Due to the high prevalence of GH deficiency (GHD) in adult thalassemic patients (Scacchi et al., Clin Endocrinol 2007), we investigated the possible role of GH - IGF-I abnormalities in the pathogenesis of the osteopenia/osteoporosis of this disease.Study: Sixty-four adult thalassemic pati...

ea0016p67 | Bone and calcium | ECE2008

Digital X-ray radiogrammetry in followed change of bone mineral density after the treatment in postmenopausal women

Galesanu Corina , Ciubotariu Ciprian , Galesanu Roxana Gabriela

Objectives: To evaluate the effect of alendronate, alfacalcidol, and combinat agent of alendronate and alfacalcidol, in BMD change assess by Digital X-ray Radiogrammetry in postmenopausal women.Materials and methods: Nine thousand and two hundred and sixty four healthy women with ages between 20 and 89 years referred to our densitometry service using DXR-BMD. Six thousand and six hundred and twelve from these were in postmenopause. Using WHO-criteria for...

ea0016p68 | Bone and calcium | ECE2008

BsmI, ApaI, TaqI, FokI polymorphisms of vitamin D receptor (VDR) gene and bone mineral density in women with Graves' disease

Horst-Sikorska Wanda , Ignaszak-Szczepaniak Magdalena , Marcinkowska Michalina , Wawrzyniak Anna , Stajgis Malgorzata , Slomski Ryszard

Graves’ (GD) hyperthyroidism induces accelerated bone turnover that leads to diminished bone mineral density (BMD). Recent studies indicate the associations between VDR gene and autoimmune diseases. The role of VDR allelic variants in predisposition to primary osteoporosis is also recognized. The authors analyzed if VDR polymorphisms: BsmI, ApaI, TaqI and FokI may predispose women with Graves’ hyperthyroidism to BMD reduction. The subjects were 7...

ea0016p69 | Bone and calcium | ECE2008

Bone metabolism in hypothalamic obesity

Doknic Mirjana , Pekic Sandra , Miljic Dragana , Stojanovic Marko , Djurovic Marina , Dieguez Carlos , Casanueva Felipe , Popovic Vera

Obesity protects from osteoporosis. Bone remodeling and energy metabolism could be regulated by the adipocyte-derived hormone, leptin acting on osteoblasts though hypothalamic pathways. Hypothalamic lesions cause obesity. Since most of these patients are also hypopituitary with low IGF1 which could affect bone metabolism the aim of our study was to investigate whether obesity would protect them from osteoporosis.Three groups of patients were studied: (1)...

ea0016p70 | Bone and calcium | ECE2008

Birth weight and the relation to lean body mass and BMC in healthy men at peak bone mass: results from the Odense Androgen Study

Frederiksen Louise , Nielsen Torben Leo , Wraae Kristian , Hagen Claus , Andersen Marianne , Brixen Kim

Background: Birth weight has been associated with low bone mass in later life. Previous studies, however, have relied on self-reported data on birth weight, included select populations, or been of a limited size. Moreover, it is unclear if the association between birth weight and bone mass is be mediated by body weight, lean body mass, or fat mass.Aim: We hypothesize that birth weight is associated with peak bone mass in men independent of current lean b...

ea0016p71 | Bone and calcium | ECE2008

Every nanogram of 25(OH)D makes a difference: subgroup analysis of institutionalized patients with vitamin D deficiency in Austria

Friedl Claudia , Dobnig Harald , Piswanger-Solkner Jutta Claudia , Obermayer-Pietsch Barbara Maria , Riedmueller Gunther , Fahrleitner-Pammer. Astrid

Elderly residents are at high risk for vitamin D deficiency due to immobilization or little opportunity of uv exposure. Decreased cutaneous capacity to form cholecalciferol and diets low in calcium and vitamin D add to this problem.In a prospective cohort study that we performed in 95 institutions in four different provinces of Austria we found that 93% of all patients had a 25(OH)D level ≤20 ng/ml. Aim of this study was to analyse whether differen...

ea0016p72 | Bone and calcium | ECE2008

Parathyroid hormone and glucocorticoid cooperatively induce RANKL mRNA expression in osteoblasts through different mechanisms

Hirano Fuminori , Kobayashi Atsushi , Maruyama Naoki , Komura Keiji , Okamoto Kensaku , Makino Yuichi , Haneda Masakazu

Glucocorticoid-induced osteoporosis is the most common form of secondary osteoporosis. Glucocorticoid is known to cause hyperparathyroidism due to parathyroid hormone (PTH) secretion. In addition, glucocorticoid and PTH have also been reported to induce RANKL mRNA expression in osteoblasts and promote osteoclastogenesis. However, little is known about cooperative effects of these hormones. The purpose of this study was to clarify the regulation of RANKL mRNA expression by gluc...

ea0016p73 | Bone and calcium | ECE2008

Hyperparathyroidism-jaw tumor syndrome (HPT-JT): a new mutation in the HRPT2-gene

Haag Christine , Pauli Silke , Schulze Egbert , Frank-Raue Karin , Raue Friedhelm

Inactivating germline mutations in the HRPT2 tumor suppressor gene are the cause of the hyperparathyroidism-jaw tumor syndrome (HPT-JT). The most common feature of HPT-JT is primary hyperparathyroidism, followed by ossifying fibromas of the maxilla and mandible, renal cysts and solid tumors. As recently recognized, mutations of this gene also play a central role in the molecular pathogenesis of parathyroid carcinoma.A 19-year-old woman presented with a g...

ea0016p74 | Bone and calcium | ECE2008

Dramatic hypocalcaemia as a cause of generalized seizures following thyroidectomy

Tauveron Igor , Forichon Caroline , Gardette Melanie , Somda Frederic , Desbiez Francoise , Gillart Thierry , Neouze Gerard , Guelon Dominique , Clavelou Pierre , Thieblot Philippe

A 56 years old woman was admitted to an intensive Care Unit for generalized seizure seven days following total thyroidectomy for toxic multinodular goiter. Thyroidectomy included self transplantation of a right parathyroid gland. Pathologic analysis confirmed benign multinodular goiter, without parathyroid tissue. Post operatively, on LT4 therapy, follow up symptoms included facial paresthesia associated to mild hypocalcaemia (1.56 mmol/l) at day 2, treated with ora...

ea0016p75 | Bone and calcium | ECE2008

Subclinical hypothyroidism and bone mineral density

Rasic-Milutinovic Zorica , Milicevic Dusan , Gluvic Zoran , Vujovic Marina , Tica Jelena , Popovic-Radinovic Vesna , Perunicic-Pekovic Gordana , Popin-Taric Marija

Objective: Hyperthyroidism is accompanied by low bone mass. Because the reference range of TSH levels is defined statistically, some individuals with high-normal TSH levels (TSH <10 mU/l), may have mild hypothyroidism (subclinical hypothyroidism) and reduced bone mass. We therefore determined whether serum TSH levels correlate with bone mineral density (BMD) in persons with subclinical hypothyroidism.Design: A cross-sectional study.<p class="abst...

ea0016p76 | Bone and calcium | ECE2008

Seasonality, sun exposure, skin type and vitamin D levels influence Parathyroid Hormone related Peptide (PTHrP) metabolism during pregnancy and after delivery in mothers and their newborns

Siafarikas Aris , Bulsara Max K , Jones Timothy W

PTHrP is an important factor for the regulation of calcium homeostasis around delivery. The aim of this study was to longitudinally analyse PTHrP metabolism and influencing factors looking at mothers and their breastfed newborns from 32 weeks of pregnancy until 8 weeks after delivery. Nineteen families (8 Caucasian, 11 Arabic/Asian) participated in the study. We analysed PTHrP, 25 OH vitamin D, parathyroid hormone (PTH), alkaline phosphatase, albumin; serum and urine calcium, ...

ea0016p77 | Bone and calcium | ECE2008

The relationship between bone turnover and body weight and leptin in patients with Anorexia nervosa

Djurovic Marina , Pekic Sandra , Miljic Dragana , Doknic Mirjana , Petakov Milan , Stojanovic Marko , Popovic Vera

Anorexia nervosa (AN) is associated with bone loss due to weight loss, decreased caloric intake, amenorrhoea and behavioral changes. The most important predictor of the occurrence of bone loss is body weight (BMI <16.5 kg/m2). Previous studies suggested that many factors including effects of chronic undernutrition in AN patients is associated with a reduction of bone formation (osteocalcin-OC) uncoupled with increased resorption markers (crosslaps-CTx). The aim ...

ea0016p78 | Bone and calcium | ECE2008

Usual values and usefulness of crosslaps in pediatric practice

Mallet Eric , Feray Agnes , Leroy Marcelle , Basuyau Jean-Paul

Serum Crosslaps is a bone resorption specific marker already validated in adults for osteoporosis helping in decision and therapeutic. Not yet clinically evaluated in children, we wanted to analyse the usefulness of this marker in paediatric practice, easier to collect than the other bone resorption markers which need urinary collection often uncertain in children.Patients and methods: Serum Crosslaps were measured using the One Step ELISA immunoassay (O...

ea0016p79 | Bone and calcium | ECE2008

Contribution of vitamin D supplementation to the vitamin D status of infants in the age of fortified milk

Mallet Eric , Basuyau Jean-Paul , Mouterde Olivier

In line with European guidelines, infant formulas in France have been vitamin D-fortified with a vitamin D3 content of ~400 IU/l. New guidelines for the prevention of vitamin D deficiency and rickets have subsequently been published and the vitamin D supplement for formula-fed infants was reduced from 800 to 400 IU per day.To contribute to the evaluation of the need for vitamin D supplementation, a study was conducted to assess vitamin D3 intake (choleca...

ea0016p80 | Bone and calcium | ECE2008

The influence of ESR1 gene genotype on bone mineral density in premenopausal women with Grave's disease

Horst-Sikorska Wanda , Marcinkowska Michalina , Wawrzyniak Anna , Ignaszak-Szczepaniak Magdalena , Stajgis Malgorzata , Slomski Ryszard

Introduction: The etiology of this autoimmune disorder results from the presence of stimulating antibodies binding to TSH receptor. The disease has a strong genetic background associated with HLA and CTLA-4 genes.The aim of study: The aim of this study was to estimate the influence of polymorphic variants of ESR1 gene on the bone mineral density in young premenopausal women with Grave’s disease (GD).Material and methods...

ea0016p81 | Bone and calcium | ECE2008

Predictors of bone mineral density in men with primary hyperparathyroidism

Tassone Francesco , Gianotti Laura , Pellegrino Micaela , Croce Chiara , Baffoni Claudia , Magro Gianpaolo , Cesario Flora , Borretta Giorgio

Introduction: In primary hyperparathyroidism (PHPT) bone involvement is frequent. In women with PHPT it has been previously reported that menopausal status together with PTH, calcium levels and renal function are independent predictors of bone density. In male subjects, the impact of PHPT on bone status is less defined.Aim of the study: To investigate this study was possible predictors of bone mineral density (BMD) in a series of male subjects affected b...

ea0016p82 | Bone and calcium | ECE2008

Primary hyperparathyroidism during pregnancy: a case report

Dogru Hulya , Bicakci Ercan , Salman Serpil , Yarman Sema , Tanakol Refik , Boztepe Harika , Alagol Faruk

Primary hyperparathyroidism (PHP) during pregnancy is a very rare event that increases maternal and fetal morbidity and mortality. Complications during pregnancy or neonatal period have included spontaneous abortion, stillbirth, neonatal death, neonatal tetany.Management of maternal PHP diagnosed during pregnancy should be based on the patients’ symptoms and severity of the disease. Hyperparathyroidism characterized by progressive symptoms should be...

ea0016p83 | Bone and calcium | ECE2008

Lack of relationship between the BsmI polymorphism in the vitamin D receptor gene and the risk of glucocorticoid-induced osteoporosis in premenopausal asthmatic women on a long-term glucocorticoid therapy

Tworowska-Bardzinska Urszula , Bidzinska-Speichert Bozena , Obojski Andrzej , Lenarcik Agnieszka

Results of many studies indicate that the BsmI polymorphism in the vitamin D receptor (VDR) gene may influence bone tissue metabolism and may be useful in identifying patients at greater risk of osteoporosis. As far as long-term glucocorticoid treatment is a major risk factor for osteoporosis development, we looked for the BsmI VDR gene polymorphism and its relation to phenotypic features characterizing bone status (BMD and metabolic bone turnover) in 74 premenopausal women: 5...

ea0016p84 | Bone and calcium | ECE2008

Intra-operative and routine intact parathyroid hormone assay on the Beckman Coulter Unicel® DxI 800

Fillee Catherine , Allaeys Jean-Michel , Delait Anne-Marie , Jarrige Veronique , Ketelslegers Jean-Marie

Background: Parathyroid hormone (PTH) assay is critical for diagnosis of calcium disorders and intraoperative (IO) monitoring of parathyroid surgery. We evaluated the new Access® Intact PTH (iPTH) on the UniCel® DxI 800 (Beckman Coulter).Methods: Imprecision was evaluated for routine and intraoperative (15 min) procedures, at 3 control levels, run 20 times in duplicate over 10 days (NCCLS EP5-A protocol). Normal values wer...

ea0016p85 | Bone and calcium | ECE2008

Clinical and hormonal variables to predict bone mineral density loss in anorexia nervosa patients

Gonzalez Amalia , Varsavsky Mariela , Fernandez Ines Luque , Leyva Socorro , Palma Moya Mercedes , Soto Marisa Fernandez

Objective: Anorexia nervosa (AN) is often associated with severe mineral bone loss and increased risk of fractures. The objective of this study was to assess the bone mineral density (BMD) in patients with AN and its relationship with different anthropometrics, clinical and hormonal parameters.Patients and methods: We evaluated 47 women with AN according to criteria of DSM-IV. The anthropometrics variables measured were: weight (kg) height (m), BMI (kg/m...

ea0016p86 | Bone and calcium | ECE2008

Vitamin D deficiency and supplementation in pregnancy, a randomised study of 180 women in four ethnic groups

Yu CYH , Newton L , Sethi M , Teoh TG , Robinson S

Objective: To determine the vitamin D status in pregnancy and to evaluate the effects of daily and of single-dose vitamin D supplementation.Design: A prospective randomised study, in an inner city ante-natal clinic.Participants: Forty-five women in each of the four ethnic groups, Indian Asians, Middle Eastern, Black and Caucasian, were studied (incomplete delivery data at time of submission).Intervention: Wom...

ea0016p87 | Bone and calcium | ECE2008

Clinical experience with Cinacalcet for treatment of persistent primary hyperparathyroidism

Martinez-Fuster Sandra , Gonzalez Victor , Lopez Alicia , Moreno-Perez Oscar , Arias Nieves , Revert Paula , Sanchez Ruth , Boix Evangelina , Pico Antonio Miguel

Introduction: In primary hyperparathyroidism (PHPT) medical treatment is indicated if the patient donot carry out the surgical criterion, donot accept surgery or there is another serious comorbidity that makes impossible the intervention. Cinacalcet is a calcimimetic that increase the sensitivity of the calcium-sensing receptor (CaSR) to ionized serum calcium, decreasing secretion of PTH and serum calcium concentration. This drug is prescribed for secondary hyperparathyroidism...

ea0016p88 | Bone and calcium | ECE2008

R-568 improves transmembrane signal transduction of inactivating mutations of the calcium-sensing receptor

Rus Ramona , Haag C , Schulze E , Frank-Raue K , Raue F , Schofl Christof

Inactivating mutations of the calcium-sensing receptor (CaSR) gene, present in homozygous or heterozygous forms, cause neonatal severe hyperparathyroidism or familial hypocalciuric hypercalcemia. The R-568 binds to the transmembrane region of the CaSR thereby enhancing its sensitivity to extracellular calcium ([Ca2+]o) and inhibiting parathyroid hormone (PTH) secretion. The therapeutic potential of calcimimetics like R-568 has been demonstrated in patient...

ea0016p89 | Bone and calcium | ECE2008

Relationship between parity and osteoporotic fractures in postmenopausal osteoporotic women (PMOW)

Papadopoulou F , Polizogoulis G , Sideridis A , Stafilidis G , Simeonidis P , Panteliadis P , Terzelidis X , Petalotidis G , Georgiadis A

Several studies have shown a positive correlation between parity and reduced hip fracture rate later in menopause while others have shown no correlation or a negative one. Thus, it is possible that some of the conflicting results reported in literature may be attributable to differences in the ages of the populations studied or of the concomitant presence or not of osteoporosis.In order to elucidate these conflicting results, a population based observati...

ea0016p90 | Bone and calcium | ECE2008

Relationship between osteoporosis and living/working environment

Georgiadis A , Tapsis K , Tseronis K , Fillipitzis I , Fitili P , Zervas K , Ziogas A , Karapiperis A , Ntavas E

Osteoporosis can be caused by many miscellaneous factors. These factors include medical, lifestyle and socioeconomic variables, the latest being not well studied and defined in international bibliography. From these there are the factors regarding the working environment (house or office) and the living environment (urban or countryside). Our hypothesis is based on the fact that women living in an urban environment or working in an office environment should have lower Bone Min...

ea0016p91 | Bone and calcium | ECE2008

Determinants of spinal deformities in adult patients with untreated growth hormone deficiency (GHD)

Mazziotti Gherardo , Bianchi Antonio , Bonadonna Stefania , Cimino Vincenzo , Fusco Alessandra , Patelli Ilaria , De Marinis Laura , Giustina Andrea

Adult GHD patients may have reduced BMD with high risk of vertebral and non-vertebral fractures which is thought to be reverted by long-term rhGH replacement therapy. In this study we aimed at identifying the determinant factors of vertebral fractures, as assessed by a radiological morphometric approach, in a cohort of adult patients with untreated GHD. Forty-two patients (27 males, 15 females; median age: 48 years, range: 30–67) with untreated severe (as defined by a pea...

ea0016p92 | Bone and calcium | ECE2008

Osteoprotegerin and bone mineral density in adult patients with celiac disease

Szymczak Jadwiga , Bohdanowicz-Pawlak Anna , Waszczuk Ewa , Tworowska Urszula

Background: Calcium and vitamin D malabsorption in celiac disease (CD) predispose to high bone turnover and skeletal demineralization. Osteoprotegerin (OPG), a member of the tumor necrosis factor receptor family, and ligand of receptor activator of NFkB (RANKL) inhibits osteoclast formation and activity.The aim of this study was to evaluate the relationship between bone mineral density (BMD), bone-turnover markers and osteprotegerin in adult patients wit...

ea0016p93 | Bone and calcium | ECE2008

Insulin sensitivity and lipid status before and after radical treatment of primary hyperparathyroidism

Kendereski Aleksandra , Micic Dragan , Cvijovic Goran , Zoric Svetlana , Sumarac-Dumanovic Mirjana , Pejkovic Danica , Simic Maja

It was previously shown that patients with primary hyperparathyroidism (PHPT) are insulin resistant. The aim of our study was to evaluate the effect of surgical treatment on insulin sensitivity and lipid levels in patients with PHPT. In 21 patients with PHPT (age: 56.24±8.69 years, BMI 25.2±3.81 kg/m2) lipid levels (TC, HDL, LDL, TG, Lp(a)) and insulin sensitivity were determinated before and 4 months after surgical treatment. Insulin sensitivity was evalu...

ea0016p94 | Bone and calcium | ECE2008

Scintigraphic, biochemical and clinical response to zoledronic acid treatment in patients with Paget's disease of bone

Avramidis Avraam , Polyzos Stergios , Moralidis Efstratios , Arsos Georgios , Efstathiadou Zoe , Karakatsanis Konstantinos , Grollios Georgios , Kita Marina

Introduction: Bisphosponates have long been used with success in the treatment of Paget’s disease of bone (PDB). The aim of this study was to evaluate the early (up to three months) and late (at twelve months) scintigraphic, biochemical and clinical response to a single intravenous infusion of zoledronic acid (ZOL) in patients with PDB serially assessed for one year.Materials and methods: Nine patients with 30 bone lesions due to PDB were prospectiv...

ea0016p95 | Bone and calcium | ECE2008

Significance of bone mineral density measurement at multiple skeleton sites

Athanassiou Panagiotis , Kostoglou-Athanassiou Ifigenia , Gerodimos Charalampos , Dadiras Nikolaos , Batsila Eirini , Kaldrymidis Philippos , Arvanitakis Miltiadis

Site-discordance in bone mineral density (BMD) assessment is common and affects patient categorization. Greater number of osteoporotic sites correlates with lower T score at each index site. The effect of BMD measurement at the contralateral femur on osteoporosis diagnosis has been previously evaluated.The aim of the study was to investigate the effect of BMD measurement at the contralateral femur on osteoporosis diagnosis.M...

ea0016p96 | Bone and calcium | ECE2008

Effects on bone turnover and bone mineral density of levothyroxine suppressive therapy in patients with benign nodular goiter

Duarte Leone , Silva-Nunes Jose , Lopes Ana-Filipa , Malheiro Fernando

Introduction: Thyroid hormones play an important role in bone metabolism. The potential action of prolonged levothyroxine therapy on bone mass reduction is still a matter of debate.Objective: The aim of the present study was to assess the effects of levothyroxine treatment on bone mineral density (BMD) and biochemical bone turnover markers.Methods: We determined thyroid function – TSH and free T4 (FT4), r...

ea0016p97 | Bone and calcium | ECE2008

A new form of hereditary low-turnover osteoporosis in a 3-generation Finnish family

Laine Christine , Saarinen Anne , Laine Tero , Makitie Outi

Juvenile primary osteoporosis, unless diagnosed as osteogenesis imperfecta, has previously been considered a sporadic and self-limiting disease. New genetic findings, including osteoporosis-causing mutations in the LDL-receptor related protein (LRP) 5 and LRP6 genes, challenge this view. The pathogenesis of juvenile osteoporosis still remains largely unknown. We describe findings in a three-generation pedigree with a new form of autosomal dominant osteoporosis.<p class="ab...

ea0016p98 | Bone and calcium | ECE2008

In utero and postnatal exposure to phytoestrogens modulates the bone mineral density of juvenile and adult female wistar rats

Diel Patrick , Degen Gisela , Hertrampf Thorsten , Ledwig Claudia , Moors Stefan , Moller Frank , Molzberger Almut , Zierau Olliver , Vollmer Gunter

Effects of phytoestrogens on female estrogen sensitive tissues are discussed controversially. There is growing evidence that exposure early in life may have a larger (and lasting) impact than an exposure later in life.To further investigate this issue we performed a study in female Wistar rats. Animals were divided into three groups: Group K received a phytoestrogen free diet, group P phytoestrogen rich diet and G a phytoestrogen free diet supplemented w...

ea0016p99 | Bone and calcium | ECE2008

Secondary osteoporosis in man with aromatase deficiency: positives and negatives of estrogen therapy

Pura Mikulas , Kottler Marie-Laure , Vanuga Peter , Carreau Serge , Vitesnik Karel , Mittre Herve

To date only seven cases of naturally occuring inactivating mutations of the aromatase gene in men have been documented. Osteoporosis is one of the typical signs of the aromatase deficiency in male patients. We report results of estrogen therapy in patient with formerly described frameshift mutation of the CYP19 gene, ins 1058 T. Bone mineral density (BMD) was assessed during three phases of estrogen therapy. Patient was substituted by calcium and vitamin D throughout t...

ea0016p100 | Bone and calcium | ECE2008

Agressive course of primary hyperparathyroidism caused by parathyroid carcinoma: case report

Vanuga Peter , Kentos Peter , Gres Alojz , Kalis Andrej , Povinec Peter , Pura Mikulas

Parathyroid carcinoma (PTCa) is an uncommon cause of primary hyperparathyroidism (PHP), statistically representing <1–2% of all cases of PHP. Early resection of the primary tumor is the only curative treatment, however this is frequently incomplete. As a consequence, recurrence of PTCa presenting as locally invasive tumor and/or metastatic process is not rare. Morbidity and mortality are generally caused by the effects of unremitting hypercalcemia rather than tumor gr...

ea0016p101 | Bone and calcium | ECE2008

FGF-23 and parameters of calcium and bone metabolism are positively influenced by GH replacement in adult growth hormone deficiency patients from the KIMS survey

Fassbender Walter , Schmitz Sandra , Stumpf Ulla , Kann Peter

Growth hormone deficiency leads to reduced bone turnover, mainly due to alterations in PTH circadian rhythmicity as well as to a lack of sensitivity of the kidney and bone to the effects of PTH. These mechanisms may be responsible for bone turnover changes and development of osteoporosis. Patients with GHD show abnormalities of renal phosphate metabolism, which may also contribute to the pathogenesis of bone loss in these patients. GH treatment leads to restoration of renal tu...

ea0016p102 | Bone and calcium | ECE2008

Endogeneous calciotropic and sex hormones and their relationship to bone mineral density in elderly females

Kemmler Wolfgang , Von Stengel Simon , Engelke Klaus , Diziol Peter , Kalender Willi A.

Purpose: To determine the effect of endogenous calciotropic and sex hormone concentration on bone parameters in postmenopausal women.Methods: We analyzed baseline data of the Senior Fitness and Prevention Study (SEFIP), an 18-month randomized controlled exercise trail with 246 females, 65 years and older. Baseline assessments of Bone Mineral Density at the lumbar spine (LS) and proximal femur were performed using DXA technique. Blood samples were taken f...

ea0016p103 | Bone and calcium | ECE2008

Exercise effect on bone anabolic hormones in elderly females: preliminary results of the senior fitness and prevention study (SEFIP)

Kemmler Wolfgang , Von Stengel Simon , Engelke Klaus , Diziol Peter , Kalender Willi A

Purpose: To determine the effect of a combined ambulatory exercise program on sex steroid concentration in postmenopausal females.Methods: The Senior Fitness and Prevention Study (SEFIP) is an 18-month randomized controlled exercise trail with 246 females, 65 years and older. The exercise group (EG) performed a vigorous endurance, strength and balance training two times per week, the ‘wellness control group’ (WG) performed a low intensity and l...