Searchable abstracts of presentations at key conferences in endocrinology
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10th European Congress of Endocrinology

ea0016p679 | Thyroid | ECE2008

Autoimmune thyroiditis (AIT) as a high-risk factor for thyroid cancer (TC)

Butyrsky Olexandr

We carried out retrospective clinic-statistical analysis of patients’ case reports been undergone for surgery. 1965–741975–841985–941995–2005Number of operations1055200436323551</t...

ea0016p680 | Thyroid | ECE2008

The influence of cure of subclinical hyperthyreosis on heart rate and autonomous nervous sytem

Kaminski Grzegorz , Makowski Karol , Dunal Agnieszka , Michalkiewicz Dariusz , Olszak Marlena , Podgajny Zbigniew , Kubik Leszek

Introduction: Subclinical hyperthyreosis (SH) affects about 1.5% population at least. The diagnosis of this disease leans on the laboratory criteria only: decreased of TSH and normal FT3 and FT4 levels. SH increases mortality and there is no unequivocal procedure algorithm to manage patients with this desease.Aim: To estimate an influence of cure of SH on heart rate and on autonomous nervous sytem and to find the relationships between parameters of Holte...

ea0016p681 | Thyroid | ECE2008

Radioactive iodide therapy for high-risk papillary thyroid carcinoma

Lin Jen-Der , Lin Kun-Ju , Chao Tzu-Chieh , Hseuh Chuen

Radioactive iodide (131I) is an effective treatment modality for papillary and follicular thyroid carcinomas. This retrospective study analyzed the role of 131I therapy in high-risk papillary thyroid carcinoma patients after surgical thyroid removal.Methods: The study analyzed 1055 consecutive high-risk papillary thyroid cancer patients, including 825 females and 230 males who underwent near-total or total thyroidectomy and follow u...

ea0016p682 | Thyroid | ECE2008

Smoking as a risk factor for thyroid volume change and incident goiter in a region of normalized iodine supply

Ittermann Till , Schmidt Carsten Oliver , Alte Dietrich , Kramer Axel , Below Harald , John Ulrich , Wallaschofski Henri , Volzke Henry

Objective: The role of smoking in the pathogenesis of thyroid enlargement is currently under debate. The aim of this paper was to investigate the role of smoking on thyroid volume change and incident goiter for different age-strata in a region with normalized iodine supply.Methods: The population-based Study of Health in Pomerania (SHIP) compromised 3300 subjects with complete 5-year examination follow-up. Data from 2484 participants without known thyroi...

ea0016p683 | Thyroid | ECE2008

Hypothyroidism and renal failure

Jones Daniel , Joshi Bhushan , Rochford Andrew , Giblin Louise

Renal impairment and electrolyte disorders in hypothyroidism are frequently subtle and rarely observed in clinical practice. Case reports have noted the association but it is rarely found in textbooks. We describe a case of new onset renal dysfunction secondary to hypothyroidism. A 54-year-old male was referred to renal clinic with new renal failure. He described a 3 weeks history of sudden onset peri-orbital, facial and generalised leg swelling and associated muscle ache and ...

ea0016p684 | Thyroid | ECE2008

Anti-BIP levels on Hashimoto's thyroiditis

Asik Mehmet , Sahin Mustafa , Arikan Serap , Gursoy Alptekin , Ayturk Semra , Bakiner Okan , Tutuncu Neslihan Bascil

To asses the presence of antibodies to BIP/GRP78, which is a chaperon of endoplasmic reticulum and has immune modulating and antiapoptotic effects in Hashimoto’s thyroiditis.The study included 62 patients with autoimmune thyroiditis. Of these, 20 had euthyroid, 27 had subclinical hypothyroid, and 15 had hypothyroid Hashimato’s thyroiditis. A control group including 37 healthy patients also participated in the study.There ...

ea0016p685 | Thyroid | ECE2008

Neither total thyroidectomy nor radioiodine remnant ablation improved long-term outcome in 900 patients with papillary thyroid microcarcinoma treated during 1945 through 2004

Hay Ian , Hutchinson Maeve , Reinalda Megan , Grant Clive , McIver Bryan , Thompson Geoffrey

The study aims were to characterize patients with papillary thyroid microcarcinoma (PTM) and to provide data on long-term outcome. About 900 patients with PTM (tumor size 1 cm or less) had treatment at our centre during 1945–2004. Follow-up extended to 54 years. Mean follow-up for 638 survivors was 13.5 years. Recurrence and mortality details were derived from a computerized database. Median tumour size was 7 mm. About 99% of tumors were grade 1; 98% were not locally inva...

ea0016p686 | Thyroid | ECE2008

Is response bias in population studies on iodine supply and thyroid disorders neglectable?

Volzke Henry , Haring Robin , Schmidt Carsten O , Alte Dietrich , Kramer Axel , Hoffmann Wolfgang , John Ulrich , Wallaschofski Henri

Context: Monitoring of iodine fortification programs is required for early recognition of oversupply or ineffective supply with iodine. Potential effects of non-response studies that are aimed at monitoring such programs have not been analysed.Objective: With the present analyses we investigated the potential role of selection bias for studies performed to monitor the iodine supply and prevalence of thyroid disorders.Design: The pr...

ea0016p687 | Thyroid | ECE2008

Expression of RNA-binding proteins TIAR and TIA-1 in thyroid tissues from patients with immune and non-immune thyroid diseases

Bossowski Artur , Czarnocka Barbara , Bardadin Krzysztof , Urban Miroslawa , Czerwinska Jolanta , Lyczkowska Anna , Dadan Jacek

TIAR and TIA-1 are two closely related RNA-binding proteins, which possess three RNA recognition motifs (RMMs). These proteins are involved in several mechanisms of RNA metabolism, including regulation of mRNA translation. In cellular apoptosis continuously TIAR shuttled between the cytoplasm and nucleus.The aim of this study was to estimate expression of closely related mRNA binding proteins TIAR and TIA-1 in thyroid tissues from young patients with Gra...

ea0016p688 | Thyroid | ECE2008

Thyroid function and volume changes in patients with end stage renal disease, before and after kidney transplantation

Sarvghadi Farzaneh , Khalili Shayesteh , Tara Ahmad

Background: Disturbance of thyroid hormones metabolism and morphology is common in ESRD (end stage renal disease) but there are discrepancies between data after transplantation. The aim of this study was assessment of the thyroid function and morphology after renal transplantation surgery.Material and method: All recipient patients, without previous history of thyroid disorders, were enrolled. Serum level of creatinine, total T3 and T4 (TT3, TT4), resin ...

ea0016p689 | Thyroid | ECE2008

Structure-function studies of thyrotropin using site-directed mutagenesis and gene transfer: development of new agonists and antagonists

Fares Fuad , Azzam Naiel , Bar-Shalom Rinat , Kraiem Zaki

Thyrotropin (TSH) and the gonadotropins (FSH, LH, hCG) are a family of heterodimeric glycoprotein hormones composed of two noncovalently linked subunits, α and β. The hTSH heterodimer was converted to a biologically active single-peptide chain (hTSHβCTPα), by fusing the common α subunit to the carboxyl terminal end of hTSHβ subunits in the presence of a ~30 aminoacid peptide from hCGβ (CTP) as a linke...

ea0016p690 | Thyroid | ECE2008

Clinicopathological characteristics of thyroid cancer in patients on dialysis for end-stage renal disease

Demirer Asli Nar , Kemal Yasemin , Tutuncu Neslihan Bascil , Gursoy Alptekin , Demirag Nilgun Guvener

Objective: Our aim was to determine the prevalence and clinicopathological characteristics of thyroid cancers in the dialysis population and to evaluate potential risk factors.Design: We performed a retrospective analysis of our end-stage renal disease (ESRD) patients on dialysis and thyroidectomized patients without ESRD (2000–2006). Then we compared the data of thyroid cancer patients on dialysis (n=9) with the data of patients who had hist...

ea0016p691 | Thyroid | ECE2008

The TRβ 1 is essential in mediating T3 action on Akt pathway in human pancreatic insulinoma cells

Misiti Silvia , Falzacappa Cecilia Verga , Patriarca Valentina , Mangialardo Claudia , Michienzi Simona , Moriggi Giulia , Bucci Barbara , Stigliano Antonio , Toscano Vincenzo

Thyroid hormone action, widely recognized on cell proliferation and metabolism, has recently been related to the phosphoinositide 3 kinase (PI3K), an upstream regulator of the Akt kinase and the involvement of the thyroid hormone receptor β1 has been hypothesized. The serine-threonine kinase Akt can regulate various substrates that drive cell mass, proliferation and survival. Its action has also been characterized in pancreatic β-cells. We previously demonstrated tha...

ea0016p692 | Thyroid | ECE2008

Rosiglitazone in two patients with thyroglobulin-positive and radioiodine-negative differentiated thyroid cancer

Martin Tomas , Fernandez-Arguelles Amaya , Torres Alberto , Gentil Alfonso , Castro Juan , Cambils Teresa

Thiazolidinediones have demonstrated some efficacy in promoting radioiodine uptake of previously poorly radioiodine-responsive thyroid cancers. We describe the effect of rosiglitazone, in promoting uptake in thyroid metastatic tissue with weak uptake in order to treatment with radioiodine in two patients.Case 1: A 62-year-old woman with thyroid cancer and negative I-131 body scan post therapy (150 mCi) with presence of recurrent disease (PET positive in ...

ea0016p693 | Thyroid | ECE2008

Effects of 8-Cl-cAMP on growth and apoptotic process in poorly differentiated thyroid cancer cell lines

Lucchi Simona , de Filippis Tiziana , Calebiro Davide , Porazzi Patrizia , Spada Anna , Persani Luca

Tools that are highly effective in the treatment of differentiated thyroid cancer (DTC) loose their therapeutic potentials in poorly differentiated tumors. The synthetic analog 8-Cl-cAMP has been known to have an antiproliferative effect in a variety of cancer cells and is tested as antineoplastic agent in clinical trials. The signaling mechanisms that govern the 8-Cl-cAMP-induced growth inhibition are still uncertain and data in thyroid neoplasia are lacking. Therefore, we te...

ea0016p694 | Thyroid | ECE2008

Cyclin A and B1 are overexpressed in thyroid cancers which had been operated for indeterminate, nondiagnostic, or suspicious fine-needle aspirate results

Demirer Asli Nar , Ozen Ozlem , Sengul Aysegul , Tutuncu Neslihan Bascil , Gursoy Alptekin , Demirag Nilgun Guvener

Objective: Approximately 30% of patients with thyroid nodules have indeterminate, nondiagnostic, or suspicious fine-needle aspiration (FNA) biopsy results. These patients usually undergo thyroidectomy because of cancer risk. Our aim was to determine diagnostic markers to distinguish benign from malignant thyroid neoplasms, so we focused on G2-M boundary regulators of the cell cycle and investigated the expression of two proteins, cyclin A and cyclin B1.M...

ea0016p695 | Thyroid | ECE2008

Semiquantitative evaluation of E-cadherin immunoexpression in the thyroid neoplasms

Klencki Mariusz , Sporny Stanislaw , Popowicz Bozena , Lewinski Andrzej , Slowinska-Klencka Dorota

Cadherins are proteins important for regulation of cell to cell adhesion. It has been postulated that the loss of cadherins may be an essential step in progression of cancer cell dedifferation, leading to increased metastatic potential. In the present study, the immunoexpression of E-cadherin was examined in various types of thyroid neoplasms and compared with that expression in normal thyroid tissue. The histopathological slides from 138 thyroid carcinomas (90 papillary, 8 fo...

ea0016p696 | Thyroid | ECE2008

Pronostic value of serum thyroglobulin measured before thyroid ablation with I131 in patients with papillary cancer meta-analysis

Sapunar Jorge , Jimenez Marcela , Ortiz Eugenia

Objective: To know the pronostic value of serum thyroglobuline (Tg), obtained before thyroid ablation with I131, in order to predict cancer recurrence risk in patients treated with total thyroidectomy due to differentiated thyroid carcinoma (DTC).Methods: We conducted a computed search of the published literature in Medline. We included diagnostic test studies that evaluated the relationship between Tg before I131 ablation, with loc...

ea0016p697 | Thyroid | ECE2008

Clinical features of TRAB negative Graves disease: a prospective study

Yener Serkan , Bayrakci Nergiz , Demir Tevfik , Bayraktar Firat , Comlekci Abdurrahman , Yesil Sena

Objective: It is well-established that hyperthyroidism of Graves disease is caused by generation of TSH-receptor stimulating autoantibodies. However, in some patients TRAB titers may be in normal levels. The rate and the burden of TRAB negative disease vary between studies. In this study, we compared the clinical and laboratory parameters of 170 patients (85 TRAB positive and 85 TRAB negative) that were diagnosed to have Graves disease in our department....

ea0016p698 | Thyroid | ECE2008

Absence of sonic hedgehog mutations in a large cohort of children with thyroid dysgenesis

Muzza Marina , de Filippis Tiziana , Gastaldi Roberto , Weber Giovanna , Lorini Renata , Beck-Peccoz Paolo , Persani Luca , Fugazzola Laura

Thyroid dysgenesis accounts for 75% of all cases of congenital hypothyroidism (CH), and includes thyroid agenesis or hemiagenesis, thyroid hypoplasia, and thyroid ectopy. Thyroid transcription factors TTF-1, TTF-2 and Pax-8, which are involved in the development of the thyroid gland and its normal migration, have been indicated as the best candidate genes but have been found to be mutated in a minority of cases. Sonic Hedgehog (Shh) protein is involved in several key events du...

ea0016p699 | Thyroid | ECE2008

Thymic hyperplasia presenting as a neck mass in Graves' disease

Yener Serkan , Secil Mustafa , Kocdor Mehmet Ali , Ozdogan Ozhan , Comlekci Abdurrahman , Yesil Sena

Introduction: Thymic hyperplasia is a rare manifestation of Graves disease. In this report, we describe a female with Graves’ disease and a neck mass that was associated with thymic hyperplasia.Case report: A 28-year-old woman was referred to our division for the evaluation of palpitations. Thyroid function tests were associated with thyrotoxicosis. Thyroid receptor antibody (TRAb) was found to be 22.3 U/l (positive: >14 U/l). Sonography showed ...

ea0016p700 | Thyroid | ECE2008

Cigarette smoking but not the TSHR germline polymorphism D727E is associated with toxic multinodular goitre (TMNG) and the thyroid volume

Jorn Jakob , Miehle Konstanze , Schmidt Claudia , Wicht Juliane , Paschke Ralf

Objective: There are contradictory results regarding the possible association of the TSHR polymorphism D727E with TMNG. Furthermore the influence of smoking on the thyroid volume has been reported by several authors. A possible association of smoking with thyroid nodules and particularly TMNG has not been investigated up to date.Methods: In this study, 88 patients with TMNG were included. Diagnosis was verified by ultrasonography, scinthiscan, and measur...

ea0016p701 | Thyroid | ECE2008

Thyronamines are isozyme specific substrates of deiodinases

Piehl Susanne , Heberer Thomas , Balizs Gabor , Scanlan Thomas , Smits Rene , Koksch Beate , Kohrle Josef

3-iodothyronamine (3-T1AM) and thyronamine (T0AM) are novel endogenous signaling molecules that exhibit great structural similarity to thyroid hormones but apparently antagonize classical thyroid hormone (T3) actions. Their proposed biosynthesis from thyroid hormones would require decarboxylation and more or less extensive deiodination. Deiodinases (Dio1, Dio2 and Dio3) catalyze the removal of iodine from their substrates. Since a role of deiod...

ea0016p702 | Thyroid | ECE2008

The outcome of radioiodine therapy of hyperthyroidism: comparison of patients with a toxic nodular goiter and with Graves' disease

Kijek Jolanta , Tarach Jerzy S , Kurowska Maria , Szymanek Bozena

Introduction: Hyperthyroidism is one of frequently encountered clinical syndromes appearing in about 2% of adult population. The aim of this study was to evaluate the efficacy of radioiodine treatment in relation to the form of hyperthyroidism.Material and methods: The study investigated 300 patients: 150 with Graves’ disease and 150 with a toxic adenoma goiter (109 with a solitary nodule and 41 with a multinodular goiter). In all the cases, the est...

ea0016p703 | Thyroid | ECE2008

Results of thyroxine therapy on thyroid nodules size in children with Hashimoto's thyroiditis

Skarpa Vassiliki , Tertipi Athanasia , Petrou Vassilios , Kostakioti Eleni , Posaghidou Elvira , Kousta Eleni , Papachilleos Petros , Kitsopoulou Aphroditi , Vakaki Marina , Fotinou Aspasia , Ioanidis Dimitris , Papathanasiou Asteroula , Hadjiathanasiou Charalambos

Aim: To study the effect of thyroxine treatment on the size of thyroid nodules in children with Hashimoto’s thyroiditisPatients and methods: Twenty-two girls and 6 boys (78.6/21.4%) were followed for 2 years under thyroxine therapy, at mean dose 1.6±0.4 μg/kg per day. Diagnosis of Hashimoto’s thyroiditis was based on the high value of either antithyroid antibodies, ATPO or ATG. Age at presentation was 10.6±2.0 year (6.2–13.6...

ea0016p704 | Thyroid | ECE2008

Refetoff syndrome associated with other congenital diseases (case report)

Kun Imre Zoltan , Szanto Zsuzsanna , Vicsi Ildiko , Reti Zsuzsanna

We report the case of a 25-year-old woman (K.Cs.) hospitalized in our clinic for endocrinological investigation, presenting a spontaneous abortion 3 weeks before hospitalization. From medical history, we mention a cerebral thrombophlebitis with intracranian hypertension syndrome, appeared after oral contraceptive drug (Diane 35R) used for 5 months. The clinically asymptomatic patient presented diffuse goiter (I. gr.), overweight and virilism, without other clinical ...

ea0016p705 | Thyroid | ECE2008

Thyroid function of pregnant women hospitalized in a section of gestational pathology

Szanto Zsuzsanna , Kun Imre Zoltan , Szabo Bela

In our previous studies, we determined the incidence of thyroid dysfunctions in pregnant women in endocrinological out-patient departments, comparing the frequency and nature of gestational complications in hypothyroid pregnant women versus pregnants without thyroid disturbances. In the present study, we proposed to appreciate thyroid dysfunctions in a clinical section of pregnant women with gestational pathology. We investigated 75 pregnant women hospitalized in the Clinic of...

ea0016p706 | Thyroid | ECE2008

Assessment of cobalt status: a comparison between goiterous children and healthy control subjects

Sanjari Mojgan , Gholamhosseinian Ahmad , Nakhaee Nouzar , Mashrooteh Mahdieh

Introduction: Cobalt is a relatively rare magnetic element with properties similar to iron and nickel. Cobalt is an essential element necessary for the formation of vitamin B12; however, excessive administration of this trace element produces goiter and reduced thyroid activity. This study was done to compare the prevalence of cobalt excess (as a cause of goiter) between goiterous and non goiterous children and to assay the relationship between serum cobalt and thyroid hormone...

ea0016p707 | Thyroid | ECE2008

Lack of apparent association of TSH receptor mutations in vitro activity with the clinical course of patients with sporadic non-autoimmune hyperthyroidism

Lueblinghoff Julia , Mueller Sandra , Sontheimer J , Paschke Ralf

Up to date, 12 patients with sporadic non-autoimmune hyperthyroidism (SNAH) caused by sporadic germline mutations in the TSHR gene have been reported. Nearly, all case reports discussed possible associations of the TSHR mutations in vitro activity (IVA) with the clinical course (CC). Therefore, we analyzed this question in a systematic review of the case reports and investigated the TSHR mutation’s IVA in selected cases.Recently, linear regre...

ea0016p708 | Thyroid | ECE2008

Phenotypic profiling of MCT8 deficient mice

Wirth Eva Katrin , Roth Stephan , Ambrugger Petra , Biebermann Heike , Kohrle Josef , Gruters-Kieslich Annette , Schweizer Ulrich

Thyroid hormones are essential for the proper development of a variety of tissues, especially the nervous system. Their transport into target cells is mediated by specific thyroid hormone transporters like the monocarboxylate transporter 8 (MCT8). Mutations in this X-chromosomal gene in humans lead to a severe phenotype characterized by psychomotor retardation, hypotonia, and a striking derangement of serum thyroid hormone levels: high T3 in the presence of low T4, and no sign...

ea0016p709 | Thyroid | ECE2008

Cinacalcet reduces serum calcium in intractable primary hyperparathyroidism (PHPT)

Marcocci Claudio , Fernandez-Cruz Laureano , Sunfa Cheng , Ren Lulu , Peacock Munro

Patients with persistent PHPT after parathyroidectomy (PTX) or contraindications for PTX often require chronic treatment for hypercalcemia, representing an unmet medical need. In an open-label, single-arm study in the US and EU, 17 patients underwent a variable length titration phase (maximum 16 weeks) with a maintenance phase (MP) of up to 3 years. Patients were eligible if they had (1) persistent PHPT following PTX or were considered contraindicated for PTX, and (2) serum ca...

ea0016p710 | Thyroid | ECE2008

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ea0016p711 | Thyroid | ECE2008

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ea0016p712 | Thyroid | ECE2008

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ea0016p713 | Thyroid | ECE2008

Subclinical hyperthyroidism, a retrospective study for 11 years

Martinez Isobel , Giralt P

Our hospital has a referent population of 50 000 people in a rural area. We have made a retrospective study about ambulatory outpatients who had been diagnosed with subclinical hyperthyroidism.Objectives: To describe and analyze the characteristics of these patients, the treatment they received, the relationship beween TSH and goiter, complementary image tests and evolution.Material and methods: This is a descriptive study about pa...

ea0016p714 | Thyroid | ECE2008

Giant subcutaneous hemorrhage mimicking anaplastic thyroid carcinoma

Tauveron Igor , Batisse Marie , Somda Frederic , Chabrot Pascal , Rosset Eugenio , Thieblot Philippe , Kemeny Jean-Louis , Boyer Louis

A 63-year-old woman was referred by her cardiologist because of rapid growth of an anterior cervical mass. The patient had a history of severe vascular atherosclerotic disease, requiring multiple prosthetic vascular surgery, among which thoracic aorta surgery, atrial fibrillation requiring coumadin and chronic respiratory failure. On admission, the patient presented with a 7 cm firm mass, regularly growing for 2 months, adherent to the cervical skin, highly suggestive of thyro...

ea0016p715 | Thyroid | ECE2008

Genetic predisposition for goiters analysed by a case control study

Wicht Juliane , Singer Joerg , Paschke Ralf

Background: Iodine deficiency is the most important exogenous factor for the development of goiters and thyroid nodules. In addition, family and twin studies as well as linkage analyses and a genome-wide scan in 18 euthyroid goiter families suggest a genetic predisposition for euthyroid goiters. However, data about the inheritance of goiters are still contradictory. Therefore, we investigated goiter predisposition by a matched case control study.Patients...

ea0016p716 | Thyroid | ECE2008

Effects on bone mineral density of supraphysiological levothyroxine doses in patients with differentiated thyroid carcinoma

Mollar-Puchades Miguel Angel , Perez-Lazaro Antonia , Merino-Torres Juan Francisco , Munoz-Vicente Monica , Segovia-Portoles Raquel , Campos-Alborg Vicente , Navas-de Solis Ma Soledad , Pinon-Selles Francisco

Introduction: The treatment of differentiated thyroid carcinoma exposes most patients to chronic supraphysiological doses of thyroid hormone which seems to have several negative effects for the patient. The goal of the present study was to assess the consequences of these doses on the bone mineral density (BMD).Patients and methods: We performed a cross-sectional study on 64 female patients followed up between 1972 and 2007. We registered the levothyroxi...

ea0016p717 | Thyroid | ECE2008

Autoantibodies to thyroid peroxidase and hypothyroidism in patients with type 1 diabetes

Sheikholeslami Homayoun , Ziaee Amir , Kani Camellia , Vahedi Siamak

Objective: Genetic susceptibility to autoantibody formation in association with autoimmune thyroid disease and type 1 diabetes mellitus has been described with varying frequencies. We have, therefore, investigated the prevalence of anti-thyroid peroxidase (anti-TPO), overt and subclinical hypothyroidism in type 1 diabetic patients.Methods: Sixty-five subjects with type 1 diabetes mellitus and 65 unrelated normal controls were recruited for the detection ...

ea0016p718 | Thyroid | ECE2008

Hypothyroidism after transarterial chemoembolization for hepatocellular carcinoma

Flohr Felix , Harder Jan , Seufert Jochen

Transarterial chemoembolization (TACE) is widely used for treatment of hepatocellular carcinoma (HCC). During this procedure approximately 20 g of iodide is applied by radiopaque material. There is usually high awareness regarding hyperthyroidism in association with contrast enhanced imaging studies and TACE. To date, however, there are no reports regarding the frequency of hypothyroidism after this procedure, although high doses of iodide can also inhibit the synthesis of thy...

ea0016p719 | Thyroid | ECE2008

Alterations of the circulating selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in patients with non-immune nodular thyroid disease

Ducena Kristine , Tretjakovs Peteris , Jurka Antra , Bormane Inga , Pirags Valdis

Cytokines, including adhesion molecules, are a family of protein mediators that are important in transducing information between various cell types, were non-immune cells may also be important sources of certain cytokines.Aim: Aim of this study was to evaluate of soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and soluble E-selectin (sE-selectin) in patients with non-immune nodular thyroid disease...

ea0016p720 | Thyroid | ECE2008

Level of von Willebrand factor in thyrotoxicosis of a various genesis

Babenko Alina , Cadinskaya Margarita , Grineva Elena

In several studies, the state of the endothelial function is analyzed in clinical thyrotoxicosis. Increased level of von Willebrand factor is detected. Many events of association of trombosis at these patients with high level of VWF are described. An association between autoimmune thyroid disease and pulmonary arterial hypertension (PAH) has been reported too. We have studied factors which influence on level of VWF at patients with a clinical thyrotoxicosis of a various genesi...

ea0016p721 | Thyroid | ECE2008

Clinical impact of positron emission tomography/computed tomography in the follow-up of well differentiated thyroid carcinoma with elevated anti-thyroglobuline auto-antibodies

Zerdoud Slimane , Dierickx Lawrence , Benlyazid Adil , Sarini Jerome , Dahimene Samir , Bastie Delphine , Bennet Antoine , Courbon Frederic , Caron Philippe

Aim: Assessment of the clinical impact of a positron emission tomography/computed tomography (PET/CT) with FDG in the management of differentiated thyroid cancer (DTC) in patients with increased or positive thyroglobulin autoantibodies (AbTg).Methodology: Retrospective study involving 15 patients seen in the follow-up with confirmed DTC primarily treated with total thyroidectomy and Iodine 131. Patients presenting with increased AbTg and a negative or no...

ea0016p722 | Thyroid | ECE2008

Thyroid hormone receptor beta gene mutation (P453A) in a family producing resistance to thyroid hormone

Bayraktaroglu Taner , Noel Janet , Alagol Faruk , Colak Nese , Mukaddes Nahhit Motavalli , Refetoff Samuel

Background: Resistance to thyroid hormone (RTH) is a dominantly inherited syndrome characterized by decreased responsiveness of target tissues to thyroid hormone. Two members of a Turkish family, a mother and son, had thyroid function tests suggestive of resistance to thyroid hormone (RTH).Methods: The clinical presentation was, however, different. The mother (proposita) had palpitation, weakness, tiredness, nervousness, dry mouth and was misdiagnosed as...

ea0016p723 | Thyroid | ECE2008

Prevalence of antibodies to thyroid peroxidase (TPO) and postpartum thyroiditis (PPT) in a cohort of 1700 pregnant women with gestational diabetes mellitus (GDM)

Sharona Azriel , Isabel Camano , Antonio Garcia-Burguillo

The prevalence of antithyroid autoantibodies in pregnant women ranges between 6 and 10%, like in the general population. PPT, a syndrome of transient or permanent thyroid dysfunction occurring in the first year after delivery, is associated with the presence of TPO in gestation. The prevalence varies from 5 to 10%, with higher frequency in patients with DM1. The aim of this study is to estimate TPO frequency during gestation and its relationship with PPT in a group of women wi...

ea0016p724 | Thyroid | ECE2008

Subclinical hyperthyroidism and insulin resistance in women with simple goiter

Tzioras Constantinos , Vryonidou Andromachi , Phenekos Constantinos

Introduction: Thyrotoxicosis has been shown to cause deterioration of glucose levels in patients with DM 2 while return to euthyroidism results in better glycaemic control. Studies in normal subjects suggest that increased thyroid hormones may aggravate insulin resistance and decrease pancreatic secretion of insulin but the exact underlying mechanisms have not been completely elucidated. The purpose of this study was to investigate if this also occurs in subclinical hyperthyro...

ea0016p725 | Thyroid | ECE2008

Treatment with thyroxine reduces thyroid volume in euthyroid children with Hashimoto thyroiditis

Scarpa Vasiliki , Kousta Eleni , Tertipi Athanasia , Ioannidis Dimitris , Petrou Vasilis , Chatziathanasiou Charalambos , Papathanasiou Asteroula

Introduction: There is no concensus whether euthyroid children with Hashimoto’s thyroiditis (HT) need treatment with thyroxine.Aim of the study: To assess whether thyroxine influences goitre progression (calculated thyroid volume on U/S scan) in euthyroid children with HT.Subjects and methods: We studied 50 euthyroid children with HT for a 2-year period. Children with a multinodular goitre were not included in the study. Twent...

ea0016p726 | Thyroid | ECE2008

Surgical management of amiodarone-associated thyrotoxicosis

Maraver Silvia , Serrano Isabel , Morales Cristobal , Martinez de Pinillos Guillermo , Garcia-Quiros Juan Manuel , Tome Monica , Jimenez-Garcia Antonio , Sendon Angel

Introduction: Amiodarone is an excellent antiarrhythmic with a high use although it isn’t free from complications. Most of patients stay euthyroid (80%), inducing thyroid dysfunction in the remaining 20% (thyrotoxicosis, 1.5–3%).Objective: We analyze amiodarona-associated hyperthyroidism surgical management according to the associated pathology and patients clinical evolution.Subjects and methods: We report four patients ...

ea0016p727 | Thyroid | ECE2008

Hashimoto’s thyreoiditis is associated with an increased occurrence of deficits in attention testing compared to patients with other thyroid illnesses

Mussig Karsten , Leyhe Thomas , Weinert Claudia , Saur Ralf , Klingberg Stefan , Gallwitz Baptist

Objectives: Experimental and clinical data point to an involvement of the central nervous system in Hashimoto’s thyroiditis (HT) independent of thyroid dysfunction. The neuropsychological function of patients with HT has not been systematically evaluated yet.Design: In the present prospective study, neuropsychological testing was performed in 26 euthyroid patients with HT compared to 25 euthyroid patients with hormonal treatment for goitre or after ...

ea0016p728 | Thyroid | ECE2008

The impact of changed body image on social relations and interpersonal behavior for patients with thyroid associated orbitopathy

Jensen Annesofie Lunde , Harder Ingegerd

Objective: Altered appearance and changed visual function characterize thyroid associated orbitopathy (TAO). TAO affects face and eyes and influences social function. It is well documented that thyroid disease influences the patient’s quality of life negatively and TAO aggravates the situation. Recently, attention has been directed towards the impact of the patient’s body image and studies show how body image dissatisfaction is a significant psychosocial complication...

ea0016p729 | Thyroid | ECE2008

Valuation of iodine deficiency in Western Andalusia by means of the neonatal screening of congenital hypothyroidism

Garcia-Quiros Juan Manuel , Morales Cristobal , Maraver Silvia , Martinez de Pinillos Guillermo , Tome Monica , Cuesta Carmen , Guerrero J M , Sendon Angel

Introduction: The accomplishment of screening neonatal congenital hypothyroidism allows the use of the determination of TSH in new born (NB) like indirect marker of the iodine ingestion of the pregnant woman and the nutritional iodine deficiency in the population. In populations with a sufficient iodine ingestion, the proportion of children with TSH superior to 5 U/ml is smaller of 3%.Primary target: To make the iodine deficiency map in the studied area ...

ea0016p730 | Thyroid | ECE2008

A poly A(−) RNA transcript (Heg) in human blood mononuclear cells is inversely related to TSH receptor autoantibodies in patients with untreated Graves' disease: gene expression of CD14 and inhibition of Cdk1

Christensen Niels Juel , Habekost Gurli , Bratholm Palle

Objective: We studied a previously uncharacterized poly A(−) RNA transcript (designated Heg) in blood mononuclear cells and its relationship to TSH receptor autoantibodies and to CD14, Nucks, Cdk1, GCRα, NF-κB and CK2 mRNA.Subjects and methods: The main study groups were a) normal subjects b) patients with early and untreated Graves’ disease and c) patients with Graves’ disease studied after treatment. Quantification of mRNA was...

ea0016p731 | Thyroid | ECE2008

Rate of thyroid cancer in a cohort of thyrotoxic patients treated with radioactive iodine

Haddad Fares , Malkawi Omar , Omari Ahmad , Abdelaziz Abdallah , Khawaldih Abdelkareem , Khawaldih Khalid , Halaseh Mais , Fayyad Luma , Kamal Nazmi

Radioactive iodine treatment for thyrotoxicosis had been introduced since 1940(s). The association of thyroid cancer and radioactive iodine (RAI131) treatment for thyrotoxicosis is rare. Rate of thyroid cancer in Jordan is 3 per 100 000 (according to Jordan National Registry).The latest population is estimated to be 5.6 million in 2006.Aim: To look for rate of thyroid cancer in a cohort of patients who received RAI131 and to report ...

ea0016p732 | Thyroid | ECE2008

Correlations between lipids and thyroid hormones in primary hypothyroidism

Savic Slavica , Trbojevic Bozo , Ciric Jasmina , Beleslin Biljana , Marina Djordje , Stojkovic Mirjana , Zarkovic Milos

The aim of the study was to assess the influence of thyroid hormones on lipid profiles in primary hypothyroidism, in order to determine the most influential one for the clinical follow-up. Study group included 15 subjects (3 male, 12 female, age 46±13 years/mean±S.D.), and total and free T4, total and free T3 and TSH, total, HDL and LDL cholesterol, triglycerides, ApoA, ApoB and Lp(a) were determined. The diagnosis of primary hypothyroidism was based o...

ea0016p733 | Thyroid | ECE2008

The role of pentagastrin stimulated calcitonin in nodular thyroid disease: will we be able to minimize false positive results?

Grossrubatscher Erika , Ciaramella Paolo Dalino , Carioni Emanuela , Cozzi Renato , Dallabonzana Daniela , Muratori Fabrizio , Oppizzi Giuseppe , Riolo Angela , Verde Giuseppe , Boniardi Marco , Pugliese Raffaele , Rossetti Ornella , Burla Teresa , Loli Paola

An increase in basal and Pentagastrin (Pg) stimulated calcitonin (CT) concentration is a specific feature of medullary thyroid carcinoma (MTC). Routine basal CT measurement in nodular thyroid diseases is controversial. Pg stimulation is expected to increase the basal CT specificity in MTC screening, although false positive responses in patients without MTC have been reported.Aim: To report the diagnostic accuracy of Pg-stimulated CT in surgically treated...

ea0016p734 | Thyroid | ECE2008

Resistance to thyroid hormones (RTH): study of a family

Santos Jacinta , Paiva Isabel , Baptista Carla , Beck-Peccoz P , Carvalheiro Manuela

Resistance to thyroid hormones (RHT) is a rare syndrome, with autosomic dominant transmission, due to mutations in thyroid hormones beta-receptor gene. Clinical presentation is variable for the same mutation. This hypothesis must be considered in presence of high levels of thyroid hormones and TSH not suppressed.The evaluation of a 15-year-old female patient, in 1990, harbouring a thyroid nodule, secondary amenorrhea and visual and auditory impairment sh...

ea0016p735 | Thyroid | ECE2008

Onset of thyrotoxicosis in patients over 65 years is associated with increased risk of skeletal and heart disease

Duncea Ileana , Georgescu Carmen , Ilie Ioana

It has been shown that aging is associated with ‘physiological’ alterations in both the hypothalamo–pituitary–thyroid axis and at the peripheral level such as elevation of basal TSH levels, often with normal T3 and T4 levels and decreased nuclear binding of thyroid hormones, particularly of T3. The frequency of nodular goiter and of an altered thyroid status increases with advancing age. The aim of our study was to analyze t...

ea0016p736 | Thyroid | ECE2008

Evolution of thyroid autonomy in iodine sufficient environment

Zmire Josip , Martinac Kresimir , Peros Kristijan , Kljajic Kristina , Colak Bozo , Sokolic Lea

Last 10 years, we are living in iodine sufficient environment. To clarify natural course of thyroid autonomy in this conditions, we investigated 100 consecutive patients in last three months – 93 female and 7 male aged 19–86 years. Included were patients with scans showing thyroid autonomy, and patients with nodular or diffuse goiter with low or suppressed TSH. We followed them from their first visit. Thirty patients were hyperthyroid – one spontaneously cured, ...

ea0016p737 | Thyroid | ECE2008

Role of deiodinases in the thyroid for the maintenance of circulating T3 levels

Chiu Jazmin , Wirth Eva , Schweizer Ulrich

Deiodinases (Dio1-3) are selenium-dependent enzymes that catalyze the reductive removal of iodine from iodothyronines. Depending on the substrate and the position of the iodine removed, deiodination can generate T3 from T4 or inactivate T3 and T4. Local expression of Dio can help to adjust the intracellular levels of T3 to the physiological needs of the organ without changing circulating T3 concentrations. It has been suggested that hepatic Dio1 generates circulating T3. Howev...

ea0016p738 | Thyroid | ECE2008

Iodine excretion and prevalence of thyroid dysfunction in the Western Part of Germany: results of the Heinz Nixdorf Recall study

Broecker-Preuss Martina , Lahner Harald , Moebus Susanne , Moehlenkamp Stefan , Roggenbuck Ulla , Joeckel Karl-Heinz , Erbel Raimund , Mann Klaus , on behalf of the Heinz Nixdorf Recall Investigator Group

Objective: While Germany was considered to be an iodine deficient area grade I to II in 1993, iodine supply has increased. With higher iodine uptake, prevalence of autoimmune thyroiditis may increase. Poor data exist on iodine supply and the occurrence of thyroid dysfunction in middle-aged adults in the western part of Germany. The aim of our study was to analyze iodine status, prevalence of TPO-antibodies (TPOab), TSH and fT4 levels in a large population-based sample in the w...

ea0016p739 | Thyroid | ECE2008

Interleukin-6 is not essential for bone turnover in hypothyroid mice

Mysliwiec Janusz , Zbucki Robert , Winnicka Maria , Sawicki Boguslaw , Nikolajuk Agnieszka , Kaminski Karol , Mysliwiec Piotr , Musial Wlodzimierz , Bondyra Zofia , Walecki Jerzy , Gorska Maria

Interleukin-6 (IL-6) has been shown to be involved in the pathogenesis of several bone diseases characterized by an imbalance between bone resorption and formation. Lately we have published our data suggesting an important role of IL-6 in thyrotoxicosis-related osteoporosis in mice (Horm Metab Res 2007 39 1–5).Aim: The aim of the study was to estimate serum markers of bone turnover: osteoclast-derived tartrate-resistant acid phosphatas...

ea0016p740 | Thyroid | ECE2008

Serum ghrelin levels are increased in hypothyroid patient and become normalized after L-thyroxin treatment

Gjedde Signe , Vestergaard Esben Thyssen , Gormsen Lars Christian , Riis Anne Lene , Rungby Jorgen , Moller Niels , Weeke Jorgen , Jorgensen Jens Otto

Context: An interaction between gut-derived ghrelin, which is implicated in the regulation of short- and long-term energy balance, and thyroid function has previously been reported in patients with hyperthyroidism, in whom ghrelin levels are reversibly suppressed. In the present study, we measured total serum ghrelin levels and pertinent metabolic indices in hypothyroid patients before end after L-thyroxin replacement.Patients and methods:...

ea0016p741 | Thyroid | ECE2008

Pharmacokinetics of digoxin in hyperthyroidism: effect of methimazole and acebutolol

Gasinska Teresa , Izbicka Maria , Dec Renata

Hyperthyroid patients show an impaired response or even resistance to digoxin treatment.Objectives: 1. Are there any differences in the pharmacokinetics of a single oral dose of digoxin between hyperthyroid and euthyroid patients? 2. Does simultaneous administration of digoxin and methimazole or digoxin and acebutolol affect the pharmacokinetics of a single oral dose of dogoxin? 3. Does methimazole-induced euthyroidism change the pharmacokinetics of a si...

ea0016p742 | Thyroid | ECE2008

Iodine metabolism and effect of 131I therapy in Graves’ disease

Kijek Jolanta , Tarach Jerzy S , Kurowska Maria

The factors influencing the final outcomes of 131I therapy are indefinitely known, besides its practical use since more than 60 years. One of the considered factors affecting the results of 131I therapy is iodine metabolism.Aim: The aim of the study was the evaluation of the iodine uptake and the effective half-life of 131I influence on the result of radioactive iodine therapy in patients treated due to Graves’ hyper...

ea0016p743 | Thyroid | ECE2008

Analysis of concomitant thyroid pathology in patients with thyroid hemiagenesis

Ruchala Marek , Szczepanek Ewelina , Zamyslowska Hanna , Czarnywojtek Agata , Sowinski Jerzy

Introduction: Thyroid hemiagenesis (TH) is a rare inborn anomaly of unclear importance. The aim of the study is to describe clinical, hormonal and autoimmunological profile of patients with TH.Material and methods: The studied group consisted of 20 subjects (4 men), diagnosed of having TH at the age from 15 to 63. Laboratory tests, including measurement of serum concentration of thyroid-stimulating hormone (TSH), free thyroxine (FT4), free tri...

ea0016p744 | Thyroid | ECE2008

Assessment of VEGF, VEGF receptor, EGF and endostatin concentrations in patients with endemic goiter

Zarzycki Wieslaw , Zonenberg Anna , Modzelewska Anna , Nikolajuk Agnieszka , Gorska Maria

Tumor angiogenesis is believed to result from an imbalance of pro- and anti-angiogenic factors. Angiogenesis is an important component in the development of thyroid goitre. Vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) represents a family of specific endothelial cell mitogens involved in normal angiogenesis and in tumor development. Consequently, a panel of anti-angiogenic factors was addressed in a representative sample of VEGF receptor-2 (VEGFR-...

ea0016p745 | Thyroid | ECE2008

Surgery, antithyroid drugs, or glucocorticosteriod in amioadarone-induced hyperthyroidism (AIH) in patients with low iodine uptake: that is the question

Czarnywojtek Agata , Ruchala Marek , Czepczynski Rafal , Szczepanek Ewelina , Sowinski Jerzy

Amiodarone is frequently used in cardiac patients but has side effects which effects the thyroid due to its high iodine content. The use of radioiodine in AIH with low iodine uptake is controversial. In these patients therapeutic choices for refractory cases include either: surgery, antithyroid drugs, or glucocorticosteriods.What are the treatment choices in elderly patients which can’t be operated on, agranulocytosis is present, or have toxic liver...

ea0016p746 | Thyroid | ECE2008

Incidental thyroid carcinomas: do they have a different clinical aggressiveness?

Ciampolillo Anna , Bellacicco Maria , Natalicchio AnnaLisa , Grammatica Luciano , Achille Gaetano , Trerotoli Paolo , Giorgino Riccardo , Giorgino Francesco

With the increasing use of thyroid ultrasound (US), the recognition of thyroid nodules in a large proportion of apparently healthy subjects has become common. Moreover, some autopsy series have shown that papillary cancer measuring 10 mm or less, the so-called papillary thyroid microcarcinoma (PTMC), is a very frequent incidental finding. Because PTMC is being increasingly discovered, it is important to ascertain whether PTMC may exhibit heterogenous clinical and pathological ...

ea0016p747 | Thyroid | ECE2008

Thyroid disorders in pregnancy

Saraf Sanjay , Saraf Sanchita , Jones Sharon

After diabetes, thyroid disorder is the second most common endocrine disorder in women of reproductive age. Thyroid disorders in pregnancy have been proven to have adverse maternal and foetal outcome if not treated adequately and timely.Aim: The aim of this audit was to assess management and therapeutic interventions and outcomes of pregnancies complicated by thyroid disorders.Method: A retrospective case notes analysis of 35 pregn...

ea0016p748 | Thyroid | ECE2008

TSH screening and thyroid disease comorbidities

Erdenen Fusun , Muderrisoglu Cuneyt , Boz Mustafa , Altunoglu Esma , Turkes Sukran , Gurcan Zeynep , Demir Pinar , Doventas Alper , Aral Hale

Background: Thyroid diseases are commonly encountered in the population though it is unanswered for whom screening tests are useful. We aimed to see the value of TSH screening and to find out comorbidities of any thyroid diseases among these patients who were diagnosed by screening.Method: All consecutive patients (n: 796) who admitted to outpatient Clinics of Internal Medicine, between 1 and 31 January 2007 were recruited in the study. Age, gende...

ea0016p749 | Thyroid | ECE2008

ProEGF cytoplasmic domain (proEGFcyt)-mediated up-regulation of SNAP25 decreases cathepsin-L secretion and elastinolytic activity in human thyroid carcinoma cells.

Glogowska Aleksandra , Kehlen Astrid , Weber Ekkehard , Los Marek , Hoang-Vu Cuong , Klonisch Thomas Klonisch Thomas

The cytoplasmic domains of EGF-like ligands have important biological functions. Stable transfectants of the human follicular thyroid carcinoma cell line FTC-133 over-expressing the cytoplasmic domain of proEGF (FTC-133-proEGFcyt) demonstrated a transcriptional up-regulation of the lysosomal hydrolases cathepsin- (cath-) B and -D and alterations in the processing of cath-L protein. Cath-L has strong elastinolytic activity and was the only of the three cathepsins to be secreted...

ea0016p750 | Thyroid | ECE2008

Impact of Cinacalcet treatment on health related quality of life (HRQOL) in patients with primary hyperparathyroidism (PHPT) who have failed or in whom parathyroidectomy (PTX) is contraindicated

Chanson Philippe , Shoback Dolores , Lu John , Cheng Sunfa , Ren Lulu , Bilezikian John

Hypercalcemic complications of PHPT include renal, cardiovascular, gastrointestinal, neuromuscular and neuropsychiatric issues, all potentially impacting negatively on HRQOL. As control of the hypercalcemia associated with PHPT might improve HRQOL, the SF-36 and a 6-item scale on cognitive functioning (CF) were included in a phase 2, single-arm study evaluating the ability of cinacalcet to control serum calcium levels in 17 patients with intractable PHPT. Mean±S.E....

ea0016p751 | Thyroid | ECE2008

Same aspects regarding immunohistochemical diagnosis of papillary thyroid carcinoma

Zosin Ioana , Golu Ioana , Cornianu Marioara , Amzar Daniela , Balas Melania

The study evaluates the expression of same immunohistochemical (IHC) markers (Ki-67, PCNA, CK-19, HBME-1 and Galectin 3, in the diagnosis of differentiated thyroid carcinomas.Material and methods: The study group comprised 57 patients with thyroid tumors; aged 17–71 years (mean age 48.96 years). All cases were evaluated before surgical treatment by means of clinical examination, thyroid ultrasonography and fine needle aspiration biopsy (FNAB).<p...

ea0016p752 | Thyroid | ECE2008

Low-T3 syndrome in chronic obstructive pulmonary disease and heart surgery patients: evaluation of plasma antioxidant systems

Mancini Antonio , Corbo Giuseppe Maria , Scapigliati Andrea , Leone Erika , Conti Mirella , Littarru Gian Paolo , Meucci Elisabetta , De Marinis Laura , Pontecorvi Alfredo

Previously, we demonstrated an inverse correlation between CoenzymeQ10 (CoQ10) and thyroid hormones, suggesting its usefulness as index of thyroid hormone tissue effect. A low-T3 syndrome, observed in chronic diseases, is considered an adaptive mechanism and its treatment is still debated. To evaluate the metabolic status of these patients and antioxidant vs energetic role of CoQ10, we studied 32 patients, with chronic obstructive pulmonary disease (COPD), comparing respirator...

ea0016p753 | Thyroid | ECE2008

Thyroid function and glucose tolerance in pregnancy: THYROMOBIL pilot study in Poland

Szybinski Zbigniew , Sokolowski Grzegorz , Gilis-Januszewska Aleksandra , Hubalewska-Dydejczyk Alicja , Stefanska Agnieszka , Buziak-Bereza Monika , Kaim Irena , Basta Antoni

Aim of the study was1. To assess the thyroid function in pregnancy in the course of effective iodine prophylaxis model introduced in 1997, based on obligatory salt iodization.2. To exam glucose tolerance and insulinemia in pregnancy.Methods: TSH, fT4, aTPO, urine iodine concentration, usg thyroid volume and homogeneity, glucose and insulin during OGTT, blood pressure, BMI, and thyroid function and glucose met...

ea0016p754 | Thyroid | ECE2008

Interference in assay of thyroid hormones due to auto-antibodies against thyroxine and triiodothyronine: report on two patients with Hashimoto’s thyroiditis

Moreno-Perez Oscar , Serrano Joaquin , Alfayate Rocio , Lopez Maite , Martinez-Fuster Sandra , Arias Nieves , Mauri Monsrrat , Pico Antonio Miguel

Introduction: Characteristically the discordant thyroid function test has been attributed to TSH-producing hypophyseal adenoma, familial dysalbuminemic hyperthyroxinemia and thyroid hormone resistance syndrome. We presented 2 cases with raised peripheral thyroid hormones with detectable TSH due to the presence of auto-antibodies against the peripheral thyroid hormones (PTAAb). <thead valign="...

ea0016p755 | Thyroid | ECE2008

Image-guided radionuclide therapy of malignant melanoma following tumor-specific sodium iodide symporter (NIS) gene transfer

Willhauck Michael , Kessel Anne , Klutz Katrin , Samani Bibi Rana Sharif , Wunderlich Nathalie , Gildehaus Franz Josef , Zach Christian , Berking Carola , Vile Richard , Goke Burkhard , Spitzweg Christine

In its early stages, malignant melanoma can be cured by surgical resection, but once it has progressed to the metastatic stage it does not respond to current therapies. Therefore, the development of novel treatment strategies, such as gene therapy, is urgently needed. To investigate an alternative approach, we examined the feasibility of NIS-mediated radionuclide therapy (131I, 188Re) of malignant melanoma following human sodium iodide symporter (NIS) gen...

ea0016p756 | Thyroid | ECE2008

The role of elevated microvessel density in the metastatic potential of papillary thyroid carcinoma

Cornianu Marioara , Golu Ioana , Lazar Elena , Dema Alis , Taban Sorina , Costi Simona , Milos Aurora , Zosin Ioana

Introduction: The value of microvessel density (MVD) as a prognostic factor in thyroid carcinomas, and its role in the development of metastasis, remain controversial.Aim: Determination of the relationship between MVD, the histological subtype of PTC, the presence or absence of metastasis in cervical lymph nodes (LN), the recurrence of the disease and AMES prognostic index.Material and method: The study included 32 patients with PT...

ea0016p757 | Thyroid | ECE2008

Thyroglobulin measurement in fine-needle aspirates of cervical lymph nodes in diagnosis of metastic differentiated thyroid cancer

Alfayate Rocio , Lopez Alicia , Martinez-Fuster Sandra , Mauri Montserrat , Moreno-Perez Oscar , Gil Santiago , De la Iglesia Pedro , Cabezas Antonio , Pico Antonio Miguel

Introduction: Serum thyroglobulin (Tg) measurement is the marker of differentiated thyroid carcinoma (DTC) after total thyroidectomy, but its value is limited by the interference of anti-Tg antibodies (TgAb). Detection of Tg in fine-needle aspiration biopsy (TG-FNAB) washout fluid is used recently to identify neck DTC metastases, but the interference of TGAb-FNAB in the procedure is unknown.Objectives: To evaluate the utility of TG-FNAB for detecting cer...

ea0016p758 | Thyroid | ECE2008

Visual evoked potentials in diagnosis of orbitopathy during the course of Graves-disease

Zgorzalewicz-Stachowiak Malgorzata , Czarnywojtek Agata , Bartkowiak Zuzanna , Komar-Rychlicka Krzesislawa , Sowinski Jerzy

Graves disease (GD) is autoimmunological disorder leading most often to hyperthyroidism and invasive-edema opthalmopathy (Graves opthalmopathy – GO).Aim: Estimation of the relation of visual evoked potentials (VEP) results with the indicators of activity and advancement of the progress of GO.Materials and methods: The examined group consisted of 45 patients between the age of 24 and 77, hospitalized in the Department of Endocr...

ea0016p759 | Thyroid | ECE2008

Some data about the epidemiology of thyroid cancer in Albania

Ylli Agron , Ylli Zamira , Lamcaj Entela , Olldashi Blertina , Shehu Medi , Furreraj Thanas , Husi Gerond , Celiku Edmond , Agolli Medi , Gjata Arben , Titka Vladimir , Nocka Albert , Karaj Agim

Introduction: Aim: the aim of our study was to give some data about the epidemiology of thyroid cancer in our country.Material and methods: We studied patients diagnosed with thyroid cancer during January 1998–October 2007.Results: We studied 179 patient from 13 to 80 years diagnosed with thyroid cancer during January 1998–October 2007. Median age at dignoses was: 46.2±14.7 years. According to the gender: females wer...

ea0016p760 | Thyroid | ECE2008

The influence of radioiodine therapy on some parameters of oxidant/antioxidant balance in patients with subclinical hyperthyroidism

Abdelrazek Saeid , Rogowski Franciszek , Zonenberg Anna , Szelachowska Malgorzata , Parfienczyk Adam , Nikolajuk Agnieszka , Szumowski Piotr , Wojno Emilia , Frackiel Malgorzata

Oxidative stress plays an important role in hyperthyroidism induced – tissue damage.We aimed to determine whether radioiodine therapy (RIT) has benefit effect on the oxidant and antioxidant status in subclinical hyperthyroidism.Material and methods: We studied 40 patients with untreated subclinical hyperthyroidism, (33 female, 7 male), aged 23–78 years; 14 patients with multinodular goitre, and 25 patients with solitary a...

ea0016p761 | Thyroid | ECE2008

Thyroid volume, selenium levels and nutritional habits in Southwestern Albania

Doupis John , Saltiki Katerina , Mantzou Emily , Mastrokostopoulos Antonios , Stavrianos Charalambos , Alevizaki Maria

Introduction: Aim: it is known that environmental factors are involved in the development of goiter. A high number of goitrous patients was identified among patients attending the general medicine outpatients’ in a mountainous region in Albania. We examined possible associations of thyroid enlargement with nutritional factors.Methods: One hundred and twelve consecutive patients (mean age 52.8±12.1, 104 female) attending the outpatients of the G...

ea0016p762 | Thyroid | ECE2008

Case report: a case of diffuse large B-cell lymphoma presented by instantaneous enlargement in a known thyroid nodule and diagnosed by fine needle aspiration biopsy

Cakir Bekir , Ersoy Reyhan , Gul Kamile , Yalcin Bulent , Korukluoglu Birol , Ustun Huseyin , Ekinci Cemil , Icli Fikri

Primary thyroid lymphoma is an uncommon malignancy; it accounts for <2% of all extranodal lymphomas and <5% of all thyroid malignancies.Case report: A 52-year-old male patient who was known to have a nodule in his thyroid gland for many years presented with instantaneous enlargement of his existing nodule and with appearance of ipsilateral cervical lymphadenopathy. On thyroid ultrasonography, a giant nodule of 38.4×31.6×45.5 mm size, an...

ea0016p763 | Thyroid | ECE2008

Case report: percutaneous laser ablation (PLA) to a functional euthyroid autonomous thyroid nodule, and histopathologic effects of PLA on nodule after thyroidectomy at 2nd year of procedure

Cakir Bekir , Gul Kamile , Ugras Serdar Nevzat , Ersoy Reyhan , Topaloglu Oya , Agac Tuba , Aydin Cevdet , Dirikoc Ahmet , Gumus Mehmet , Korukluoglu Birol , Kusdemir Ahmet

Objective: Percutaneous laser ablation (PLA) is a new procedure utilized to decrease nodule volume in symptomatic thyroid nodules, to provide euthyroidism in autonomous hyperfunctioning nodules, and to decrease compressive symptoms palliatively in malignant nodules. Standard treatment in autonomous thyroid nodules is radioiodine and surgery. In this report, we aimed to present this case to demonstrate changes in nodule histopathology, which was undergone thyroidectomy two year...

ea0016p764 | Thyroid | ECE2008

Clinical features and outcome of papillary thyroid cancers <2 cm: univariate and multivariate analyses

Perrino Michela , Vannucchi Guia , Vicentini Leonardo , Dazzi Davide , Peccoz Paolo Beck

An increasing prevalence of papillary thyroid carcinomas (PTC) of small size have been recorded in recent years. These tumors have a favorable outcome in most cases, and total thyroidectomy without radioiodine therapy is suggested for microcarcinomas (defined as ≤1 cm). The 6th edition of the TNM staging system for thyroid cancers includes in the T1 category tumors ≤2 cm, limited to the thyroid. Aim of the present study was to evaluate the clinical/pathological fea...

ea0016p765 | Thyroid | ECE2008

A prospective study on a large series of non toxic multinodular goiters treated with radioiodine: results at long term follow-up

Vannucchi Guia , Mannavola Deborah , Chiti Arturo , Dazzi Davide , Rodari Marcello , Tadayyon Sara , Beck-Peccoz Paolo , Fugazzola Laura

Radioiodine (131I) administration has been found to be effective in the treatment of hyperfunctioning and normofunctioning multinodular goiter. Moreover, lithium therapy has been shown to enhance the radioiodine efficacy and to reduce the transient thyrotoxicosis induced by radioiodine.Aim of the present study was to evaluate the long term efficacy of 131I with or without lithium administration in the treatment of non toxic multinod...

ea0016p766 | Thyroid | ECE2008

Higher prevalence of nodular goiter and thyroid carcinoma in patients with familial adenomatous poliposis (FAP)

Zirilli Lucia , Romano Stefania , Madeo Bruno , Carani Cesare , Benatti Piero , De Leon Maurizio Ponz , Roncucci Luca , Rochira Vincenzo

FAP is a dominant autosomic syndrome, due to mutation of the APC oncosuppressor gene, characterised by adenomatous polyps at the colon–rectal level, that progres to malignant degeneration. FAP extraintestinal manifestations include, although rare, the thyroid nodules and tumours. Neck ultrasound (US) is routinely useful to identify thyroid nodules, but the characterisation of their nature requires the cytology by a FNAb. The exact incidence of the thyroid tumours on FAP s...

ea0016p767 | Thyroid | ECE2008

Case report: subcapsular hematoma complication during percutaneous laser ablation (PLA) to a hypoactive benign solitary thyroid nodule, and literature review of PLA- related complications

Cakir Bekir , Gul Kamile , Ersoy Reyhan , Topaloglu Oya , Agac Tuba , Aydin Cevdet , Dirikoc Ahmet , Gumus Mehmet , Korukluoglu Birol , Kusdemir Ahmet

Objective: Ultrasound (US) guided percutaneous laser ablation (PLA) is a new procedure utilized to decrease nodule volume in symptomatic thyroid nodules, to provide euthyroidism in autonomous hyperfunctioning thyroid nodules, and to decrease compressive symptoms palliatively in malignant nodules. Standard treatment protocol in symptomatic benign hypoactive thyroid nodules is surgery, if needed LT4 suppression, and radioiodine treatment in certain applications. We applied PLA t...

ea0016p768 | Thyroid | ECE2008

Thyroid size and thyroid function in children from iodine deficiency regions

Abdushelishvili Nino , Gordeladze Marine , Sekhniashvili Zurab , Svanidze Marina

Background and aims: Diffused endemic goiter (DEG) development is not always explained by increased TSH levels. Most DEG patients (pts) have normal TSH concentrations, with tendency to decreased T4 and normal or slightly elevated T3. In the present study levels of thyroid hormones (TH) in pts with various degrees of thyroid size (TS) and weak iodine deficiency (ID) were analyzed.Material and methods: In total DEG 137pts, aged 2–16 years were studied...

ea0016p769 | Thyroid | ECE2008

The influence of chronic GH excess upon thyroid gland morphology evaluated by ultrasound

Buzduga Catalin , Ananie Teodora Emiliana , Mogos Simona , Zbranca Eusebie , Galesanu Corina , Mogos Voichita , Branisteanu Dumitru D

It is known that thyroid pathology is generally more frequently found in women than in men. The somatotroph axis stimulates skeleton growth, but also the development of smooth tissues, including the thyroid gland. We investigated the effect of chronic GH excess upon ultrasound-evaluated (7.5 MHz linear probe) thyroid gland morphology of 74 patients (40 women şi 34 men) diagnosed with acromegaly. When compared to mean thyroid volume of age- and sex-matched non-acromegali...

ea0016p770 | Thyroid | ECE2008

New mutations demonstrate intracellular iodine retention in Pendred syndrome

Garcia-Rendueles MER , Bravo SB , Palos F , Cameselle-Teijeiro J , Czarnocka B , Dominguez-Gerpe L , Lado-Abeal J , Alvarez CV

Pendred syndrome is an autosomal recessive disorder with congenital-sensorineural deafness and goiter due to mutations in SLC26A4, that encodes a transmembrane protein, Pendrin. In thyrocytes, Pendrin is proposed to act at the apical pole to transport intracellular iodide into the follicular lumen.A Galician Pendred compound heterozygous patient was studied; a c.297delT in exon 3 and a new splicing-mutation c.416-1G<A were found, introducing p...

ea0016p771 | Thyroid | ECE2008

Thyroid hormone replacement using a combination of levothyroxine plus slow-release liothyronine: beyond proof of principle

Tevaarwerk Gerald JM

Objective: To assess if adding slow-release liothyronine (SR-T3) to levothyroxine (l-T4) reduces persistent hypothyroid symptoms and signs on replacement with l-T4 alone.Design: Open label, two-period cross-over, cohort comparison. The main outcomes were changes in the serum T3 concentration and residual clinical hypothyroid indicants. Each study period was 10 weeks. The sample size required was d...

ea0016p772 | Thyroid | ECE2008

Usefulness of thyroid echographic pattern description: predictive value at onset and in the evolution of thyroid diseases

Peretianu Dan , Staicu Daniela Cristea , Carsote Mara

Objectives: The study of the real indications for thyroid ultrasound and in which pathological conditions the echography is of real use and not for abuse.Material and methods: In the last 10 years, over 13 000 echographies were performed in 5136 consecutive patients for ‘thyroid disturbances’. In a previous paper we described 7 echographic patterns for thyroid ultrasound (9th ECE). The diagnosis of Hashimoto’s thyroiditis (HT) was consider...

ea0016p773 | Thyroid | ECE2008

Surprising: hyperlipidemia in subclinical hyperthyroidism!

Marina Ljiljana , Vujovic Svetlana , Ivovic Miomira , Tancic-Gajic Milina , Stojanovic Milos , Barac Marija , Drezgic Milka

Subclinical hyperthyroidism is a biochemical diagnosis defined with suppressed levels of TSH and normal levels of thyroid hormones. One of the main metabolic responses to thyroid hyperfunction is peripheral lipolysis and release of free fatty acids (FFA). The aim of this study was to compare levels of cholesterol, LDL, HDL and triglycerides in persons with subclinical hyperthyroidism to age and BMI matched euthyroid healthy control. We evaluated 45 persons in two groups: 1st g...

ea0016p774 | Thyroid | ECE2008

The variation intercellular adhesion molecule-1 level in primer and postoperative hypothyroid patients with treatment

Ozkaya Mesut , Cakal Erman , Yuzbasioglu M Fatih

Background and aims: It is reported that intracellular adhesion molecule-1 (ICAM-1) is important in autoimmune thyroid diseases also it is an important point that ICAM-1 level is high in postoperative hypothyroid cases. In literature, it is said that the level of plasma soluble ICAM-1 can be used as a evidence immune system activation and inflammation, and also it can be used for the diagnosis of some inflammatory and autoimmune diseases. The aim of our was to compare the leve...

ea0016p775 | Thyroid | ECE2008

Tuberculosis of the thyroid gland: the chameleon of thyroid pathology

Zbranca Eusebie , Branisteanu Dumitru D , Zbranca Veronica , Pencea Vera , Dobrescu Gioconda , Mogos Voichita , Galesanu Corina , Hurmuzache Stefania , Zbranca Anca

Tuberculous thyroiditis is a very rare disease. Its clinical features are non-specific in most of the cases, mimicking other thyroid diseases. Confusions most frequently made are those with thyroid cancer and toxic nodular goiter. Therefore, diagnosis often comes as a histopathological surprise, after thyroid ablation for other reasons.Thyroid tuberculosis was diagnosed histopathologically in six out of 1232 cases of thyroid surgery. Preoperatory diagnos...

ea0016p776 | Thyroid | ECE2008

Is thyroid tuberculosis actually not rare?

Yuzbasioglu M Fatih , Ozkaya Mesut , Cakal Erman , Ciralik Harun , Okur Nazan , Gisi Kadir

Background and aim: Thyroid gland is considered to be rare site of extrapulmonary tuberculosis (tbc), even in countries with a high prevalance. The aim of this study is to ases the correlation between thyroid nodules and pulmonary tbc with fine needle aspiration cytology (FNAC) and to find out the incidence of thyroid gland tbc.Material and methods: The main purpose of this study is to find out tbc incidence in pulmonary tbc patients with thyroid nodules...

ea0016p777 | Thyroid | ECE2008

Hypothyroidism due to primary hypotriiodothyronaemia: a case report

Tevaarwerk Gerald JM

Objective: Report of hypothyroidism due to primary hypotriiodothyronaemia caused by a deficiency in peripheral generation.Design: Case report and computer modelling.Main outcome: A 28-year-old woman presented with hypothyroid symptoms and delayed ankle reflex relaxation times. She was not on any medications. The average thyroid stimulating hormone (TSH) concentrations was 2.5 (N: 3.8–5.5 mU/l), free thyroxine (T4) 12.3 ...

ea0016p778 | Thyroid | ECE2008

Hashimoto’s encephalopathy: a rare cause of status epilepticus

Edavalath Mahamood , Cossburn Mark , Rees Aled

Background: Hashimoto’s encephalopathy is a rare steroid-responsive condition associated with high antithyroid antibody titres. We report a case of autoimmune thyroiditis presenting with status epileptics.Case: A 36-year-old non-epileptic Caucasian lady presented as an emergency with uncontrolled generalised seizures requiring sedation, short-term ventilation and maintenance sodium valproate therapy. Further enquiry revealed a 3–4 week history ...

ea0016p779 | Thyroid | ECE2008

Thyroid function is associated with insulin sensibility

Volkova Anna , Grineva Elena , Dora Svetlana

Thyroid disease is associated with atherosclerosis cardiovascular disease. This is undoubted for overt hypothyroidism, but is controversy in subclinical hypothyroidism hittle is known about the relationship between insulin resistance and thyroid function. It is well known that insulin resistance is the main part of metabolic syndrome. We aimed to investigate the relationship between thyroid function, body mass index (BMI) and homeostasis model assessment index for insulin resi...

ea0016p780 | Thyroid | ECE2008

Severity of coronary atherosclerosis in patients with different TSH levels

Volkova Anna , Grineva Elena , Dora Svetlana

Subclinical hypothyroidism (SH) is very frequent condition in older population. If can occur in 12–20% of patients older than 60. It is well known today that thyroid hormones can increase gene expression of APO-B receptors in the liver and by this way improve catabolism of atherogenic lipoproteins. They also can regulate processes of contractility and weakening of heart muscle. Decrease of cardiac output and diastolic disfunction of left ventricle can be revealed in SH pa...

ea0016p781 | Thyroid | ECE2008

Iodine status in pregnant women: do they have sufficient information about the importance of iodine nutrition during the pregnancy?

Marco Amparo , Vicente Almudena , Castro Enrique , Canovas Barbara , Sastre Julia , Cruces Eva , Maqueda Esther , Iglesias Maria Lopez , Lopez Jose Lopez

The recommended nutrient intake (RNI) for iodine during pregnancy has been re-evaluated in 2005 by an international expert committee under the auspices of the World Health Organization (WHO). The consensus reached was that the RNI for iodine during pregnancy should range between 200 and 300 μ/d with an average of 250 μ/d.To asses the adequacy of the iodine intake during pregnancy in a population, urinary iodine concentration (UIC) should be mea...

ea0016p782 | Thyroid | ECE2008

Is Graves' disease the most frequent immune association with Hashimoto thyroiditis?

Poiana Catalina , Peretianu Dan , Carsote Mara , Calinesti Larisa Ionescu

Aim: To re-evaluate the prevalence of autoimmune associations in Hashimoto’s thyroiditis (HT).Subjects and methods: The study was performed on 469 consecutive patients with HT and 536 without. The diagnosis of HT was based on an antithyroperoxydase antibodies (ATPO) level above 34 IU/ml. The subjects were evaluated for other associated immune diseases. The statistical analysis used the χ2 test.Results: F...

ea0016p783 | Thyroid | ECE2008

Effects of thyroid-stimulating hormone suppression with levothyroxine in reducing the volume and prevention the growth of solitary thyroid nodules

Mijailovic Vesna , Mijailovic Milan , Micic Dragan

Suppressive therapy with thyroxine is the standard conservative treatment for solitary benign thyroid nodules. However, factors which may influence the response to treatment remains controversal, as well as the risc of thyroxine administration.We prospectively evaluated the effects of twelve months thyroid-stimulating hormone suppression with Levothyroxine (L-T4) in reducing the volume of benign solitary nodules, and the effects of reduced...

ea0016p784 | Thyroid | ECE2008

Growth inhibitory actions of human proepidermal growth factor cytoplasmic domain (proEGFcyt) are mediated by the ubiquitin-proteasome system in human thyroid carcinoma cells

Glogowska Aleksandra , Weber Ekkehard , Los Marek , Hoang-Vu Cuong , Klonisch Thomas Klonisch Thomas

The cytoplasmic domain of the membrane-anchored human EGF proform is encoded by exons 22–24 and the function of this proEGFcyt is largely unkown. Stable transfectants of the human thyroid carcinoma (Ca) cell line FTC-133 were generated over-expressing (a) proEGFcyt, (b) truncated peptide version encoded by exons 22 and 23 (proEGF22.23), and (c) a natural splice version with a deletion of exon 23 and 24 (proEGFdel23). ProEGFcyt and proEGF22.23 transfectants, but not proEGF...

ea0016p785 | Thyroid | ECE2008

Isolated ACTH deficiency as a cause of impaired well-being in patients with primary hypothyroidism

Bender Gwendolyn , Cromme Claudia , Hahner Stefanie , Arlt Wiebke , Luster Markus , Reisch Nicole , Reinke Martin , Allolio Bruno

Objective: Isolated ACTH-deficiency (IAD) is considered a rare autoimmune endocrinopathy most frequently associated with autoimmune thyroid diseases (ATD). We have previously diagnosed IAD in four patients with primary hypothyroidism and negative TPO antibodies. The aim of this study was to determine the prevalence of undiagnosed IAD in patients with ATD.Methods: We studied 45 patients with ATD on stable L-thyroxine replacement (dose range...

ea0016p786 | Thyroid | ECE2008

From elimination to sustainable control over iodine deficiency in Bulgaria 1997–2006

Stoeva Iva

Iodine deficiency (ID) and ID disorders (IDD) are a global problem. ID elimination would significantly contribute to achieving at least 6 of the 8 millennium developmental goals.Aim: To adapt the Neonatal thyroid screening (N?S) based on TSH with a view to its applicability as a permanent indicator in monitoring the effect from the iodine prophylaxis of IDD in Bulgaria.Tasks: To study: 1) dependence of TSH on age after birth; 2) in...

ea0016p787 | Thyroid | ECE2008

Should we look for metabolic syndrome (MSy) in subclinical hypothyroidism?

Drezgic Milka , Marina Ljiljana , Ivovic Miomira , Tancic-Gajic Milina , Stojanovic Milos , Barac Marija , Vujovic Svetlana

Subclinical hypothyroidism is a biochemical diagnosis defined with elevated levels of TSH and normal levels of thyroid hormones. The most common abnormality linked to this condition is hypercholesterolemia. The aim of this study was to search for MSy among the persons with subclinical hypothyroidism which was already proven to have hypercholesterolemia when compared to healthy control. MSy was identified in those with elevated triglycerides (Tgc), reduced HDL and elevated fast...

ea0016p788 | Thyroid | ECE2008

Hurthle cells tumors of the thyroid: personal experience at the Regina Elena Cancer Institute, Rome (Italy)

Barnabei Agnese , Baldelli Roberto , Pasimeni Giuseppe , Appetecchia Marialuisa

Hurthle cell carcinoma (HCC) represents about 5% of differentiated thyroid carcinomas. When Hurtle cell represents more than 75% of cells population, the lesion can be considered a Hurthle cell tumor (HCT); it can be classify as malignant when capsular or vascular invasion is reported or if there is a perithyroid infiltration or distant metastases occur. Aim of this study was to present our own experience on the clinical and pathological features of patients (pts) affected by ...

ea0016p789 | Thyroid | ECE2008

Radioiodine therapy in patients with toxic nodular goitre

Abdelrazek Saeid , Rogowski Franciszek , Zonenberg Anna , Parfienczyk Adam , Szelachowska Malgorzata , Gorska Maria , Szumowsk Piotr , Wojno Emilia , Frackieli Malgorzata , Karpinska Urszula

The aim of our study was to assess the effectiveness of radioiodine therapy (RIT) on the achievement of euthyroidism and reduction of thyroid volume, in patients with toxic nodular goitre (TNG).Material and methods: During the last 7 years, we treated 3800 patients with TNG, aged 30-70 years; 82% female and 18% male; 2200 patients with multinodular goitre (MNG) and 1600 with autonomous toxic nodule (ATN); thyroid volume ranged between 16 and 130 ml (30% ...

ea0016p790 | Thyroid | ECE2008

A case of thyroid abscess due to piriform sinus fistula complicated by hyperthyroidism

Marie Batisse , Frederic Somda , Fancoise Desbiez , Thierry Mom , Philippe Thieblot , Igor Tauveron

Acute suppurative thyroiditis is a rare disease because thyroid gland is highly resistant to infection. The most common predisposing factor is the presence of a piriform fistula. We report an unusual case of hyperthyroidism caused by AST.A 27-year-old woman was admitted to our hospital because she presented a painful swelling in the left thyroid gland with fevers. Laboratory test showed a white leukocyte count of 14 000/μl, a CRP level of 251 mg/l, ...

ea0016p791 | Thyroid | ECE2008

Cognitive dysfunctions during chronic thyrotropin-suppressive therapy with levothyroxine in patients with differentiated thyroid carcinoma

Lacka Katarzyna , Kucharska Aleksandra , Rajewska-Rager Aleksandra , Jaracz Jan

Background: TSH-suppressive therapy is widely used in treatment of thyroid differentiated carcinoma. A common consequence of therapy is subclinical hyperthyroidism which may cause dysfunction of cardiovascular system, metabolism and reduction of bone mass1. Thyroid hormones are also involved in regulation of brain function2. Therefore, it is not surprising that thyroid dysfunctions are associated with frequent comorbid cognitive dysfunctions and depressio...

ea0016p792 | Thyroid | ECE2008

Serum ghrelin levels in thyroid dysfunction and its change with treatment

Karaca Zuleyha , Yetkin Ilhan , Yilmaz Murat

Aim: In this study, we aimed to detect the serum Ghr levels in hypo and hyperthyroid patients at the time of diagnosis and after treatment in comparison with an age-, and sex-matched control group.Materials and methods: Thirty-two hypothyroid, 19 hyperthyroid and 30 control subjects were included in the study. Basal levels of serum free T3, free T4, TSH, anti-thyroid peroxidase (anti-TPO), anti Tg antibodies were measured by commercially available kits i...

ea0016p793 | Thyroid | ECE2008

Hyperthyroidism associated to hyperthyrotropinemia: differential diagnosis between resistance to thyroid hormone and TSH secreting pituitary adenoma

Paragliola Rosa Maria , Locantore Pietro , Ingraudo Francesca , Gallo Francesca , Ianni Francesca , De Rosa Annapina , Rota Carlo Antonio , Pontecorvi Alfredo , Corsello Salvatore Maria

Hyperthyroidism associated to hyperthyrotropinemia is a rare condition which can be due to two different causes: resistance to thyroid hormones and TSH secreting adenoma. The differential diagnosis is not easy.We have observed 8 patients with hyperthyroidism associated to inappropriately elevated TSH. All patients had similar basal levels of thyroid hormones and 7 out of 8 had a multinodular goiter.Four out of 8 patients showed lac...

ea0016p794 | Thyroid | ECE2008

Decreased fibrinolytic activity due to levothyroxine suppression therapy for benign thyroid nodules

Demir Tevfik , Akinci Baris , Comlekci Abdurrahman , Karaoglu Oguzhan , Yener Serkan , Ozcan Mehmet Ali , Yuksel Faize , Secil Mustafa , Yesil Sena

Thyroid dysfunction is associated with altered levels of several coagulation factors. The aim of this study is to investigate the effect of levothyroxine suppression therapy for benign thyroid nodules on coagulation system.Thirty-six patients with benign thyroid nodules, who were applicant for levothyroxine suppression therapy, were included in the study. Thirty patients completed 1 year follow-up period. Levothyroxine was given to maintain TSH level bet...

ea0016p795 | Thyroid | ECE2008

Graves’ disease and myasthenia gravis: who comes first?

Vulpoi Carmen , Andriescu Lidia , Ciobanu Delia Gabriela , Ungureanu Maria Christina , Cuciureanu Dan , Grigoras Mihai , Zbranca Eusebie

Graves’ disease (GD) and myasthenia gravis (MG) may be associated and influence one another clinical expression. We report the cases of 3 female patients who presented this particular association. First patient (RL, 55 years), was diagnosed with MG and, 5 years after, developed GD, remitted after 2 years of anti-thyroid drugs (ATD). She is still euthyroid after more than 10 years, and MG is compensated with moderate doses of anticholinesterase drugs (ACD). Thoracic CT sho...

ea0016p796 | Thyroid | ECE2008

Iodine deficiency disorders in eastern Ukraine

Zelinska Nataliya , Mamenko Marina

Background: Ukraine does not yet have a national program for control of iodine deficiency and there are no recent data on the severity of the iodine deficiency disorders (IDD) in the country.Objective: The aim of the present study was to assess current IDD status in eastern Ukraine.Design: We conducted school-based 30-cluster survey in children 6-11-year-old in urban and rural areas. We measured urinary iodine concentration (UI) an...

ea0016p797 | Thyroid | ECE2008

The effect of radioiodine therapy in patient with subclinical hyperthyroidism

Abdelrazek Saeid , Rogowski Franciszek , Szelachowska Malgorzata , Parfienczyk Adam , Zonenberg Anna , Wojno Emilia , Szumowski Piotr , Karpinska Urszula , Marciniak Marta

The aim of our study was to assess the influence of radioiodine (131I) therapy on the achievement of euthyroidism, prevention of adverse effects on the cardiovascular and skeletal systems and prevent evolvement to overt hyperthyroidism.Material and methods: We treated 630 patients, aged 30–70 years; 85% of them were female and 15% male; 220 patient with multinodular goitre (MNG), and 310 patient with autonomous nodule (ATN). Some of the p...

ea0016p798 | Thyroid | ECE2008

Abstract unavailable...

ea0016p799 | Thyroid | ECE2008

Thyroid hormone abnormalities in chronic renal failure

Horacek Jiri , Sulkova Sylvie Dusilova , Malirova Eva , Bednarova Vladimira , Simkovic Martin , Sulek Stepan , Vizda Jaroslav , Maly Jaroslav

In 162 patients with end-stage renal disease (ESRD), 112 on maintenance haemodialysis (HD) and 50 on continuous ambulatory peritoneal dialysis (CAPD), thyroid status was evaluated: thyrotropin (TSH, IRMA, normal range 0.15–5 mU/l), total thyroxine (TT4, RIA, 70–140 nmol/l), free thyroxine (FT4, RIA, 11–25 pmol/l), total triiodothyronine (TT3, RIA, 1–3 nmol/l), free thyroxine (FT3, RIA, 2.5–5.8 pmol/l); in 113 patients (63+50) also reverse T3 (RT3, RIA,...

ea0016p800 | Thyroid | ECE2008

Insulin resistance and oxidative stress induce advanced glycation end products formation in patients with clinical and subclinical hypothyroidism

Peppa Melpomeni , Hadjidakis Dimitrios , Alevizaki Maria , Dimitriadis George , Isari Georgia , Economopoulos Theofanis , Uribarri Jaime , Vlassara Helen , Raptis Sotirios A

Introduction: Advanced glycation end products (AGEs) formation is accelerated in various pathological conditions characterized by insulin resistance (IR) and/or increased oxidative stress (OS). Hypothyroidism – overt (OH) or subclinical (SUH) – is associated with a variety of metabolic disorders leading to IR and increased OS.Aim: To estimate the εN-carboxymethyl-lysine (CML) levels, in subjects with OH and SUH and seek f...

ea0016p801 | Thyroid | ECE2008

TSH levels and thyroid nodules correlation in autoimmune thyroiditis

Vianale Luigi , Remigis Alessandra De , Ranieti Paola , Remigis Pierluigi De

The role of TSH in the pathogenesis of thyroid nodule (TN) is controversial.We have evaluated the prevalence of TN in a group of 800 subjects with and without autoimmune thyroiditis (AT). The prevalence of TN, the number and volume of nodules was evaluated in relation with TSH and antithyroid antibodies titles.The subjects were of both sex, aged between 20 and 80 years and were recruited in a random manner, in the context of an epi...

ea0016p802 | Thyroid | ECE2008

Serum thyrotropin concentration as a biochemical predictor of thyroid malignancy in patients presenting with thyroid nodules

Polyzos Stergios , Kita Marina , Efstathiadou Zoe , Poulakos Pavlos , Slavakis Aristidis , Sofianou Danae , Flaris Nikolaos , Leontsini Maria , Kourtis Anargyros , Avramidis Avraam

Background: Fine-needle aspiration biopsy is the ‘gold standard’ in the preoperative management of thyroid nodules.Aim: The aim of this study was to investigate whether serum TSH is a predictor of thyroid malignancy in patients presenting with thyroid nodules.Subjects and methods: About 565 patients without overt thyroid dysfunction, who presented with palpable thyroid nodule(s) between 1988 and 2004 and underwent at leas...

ea0016p803 | Thyroid | ECE2008

Thyroid peroxidase antibodies and levels of thyroid stimulating hormone as predictors of development of hypothyroidism in euthyroid subjects

Roos Annemieke , Links Thera , Jong-van den Berg Lolkje de , Gans Rijk , Wolffenbuttel Bruce , Bakker Stephan

Introduction: Presence of thyroid peroxidase antibodies (TPOAbs) may be a marker of future thyroid failure. However, prospective studies in a euthyroid population have not been performed.Aim of the study: To prospectively investigate the relationship between presence and levels of TPOAbs and incident hypothyroidism in euthyroid subjects in the general population.Study population: The database used for this study consisted of a rand...

ea0016p804 | Thyroid | ECE2008

The effect of radioiodine therapy in patient with non-toxic goitre after pre-treatment with a single dose of recombinant human thyroid stimulating hormone (rhTSH)

Abdelrazek Saeid , Parfienczyk Adam , Rogowski Franciszek , Szumowski Piotr , Kociura-Sawicka Agnieszka , Wojno Emilia

The aim of our study was to assess the effectiveness of radioiodine therapy (RIT) on the reduction of thyroid volume after pre-treatment adjunct of rhTSH in patients with non-toxic goitre with low RAIU.Material and methods: We treated 36 patients; (28 female, 8 male) aged 35–77 years. Initial 24 h RAIU was ranged between 5 and 17%, and thyroid volume ranged between 42 and 128 ml. Twelve patients had compressive symptoms. Malignant changes were exclu...

ea0016p805 | Thyroid | ECE2008

High prevalence of pathologic TSH values in patients admitted to a clinic of general internal medicine

Reinhardt Walter , Gross Oliver , Jockenhoevel Friedrich

Currently there are only rare data on the prevalence of thyroid dysfunction in hospitalized patients. Therefore, we prospectively measured TSH values in patients admitted to a clinic of general internal medicine in an area of moderate iodine deficiency.In 1011 patients (mean age 66.2 years; median 72 years) TSH was consecutively evaluated.The mean TSH was 1.74 μU/ml (range 0.00–93.3); median 1.1 μU/ml.<p class="a...

ea0016p806 | Thyroid | ECE2008

A rare clinical picture: thyroid cystic nodule as a localization of Aspergillus pulmonary infection (pulmonary-thyroid form)

Remigis Pierluigi De , Liberato Lorenzo Di , Pizzigallo Eligio , Remigis Alessandra De , Bisello Walter , Emma Francesco , Vivarelli Marina , Vianale Luigi

Aspergillus infection (A)is often recognized in severely immunocompromised patients.Although involvement of the thyroid gland is reported for 9–15% of patients with disseminated disease, a localized clinical picture it’s not reported.Here, we present a case of Aspergillus in a LES young patient (15-year-old girl), who underwent to a strong immunosuppressive regimen (high doses of corticosteroids, endoxan and...

ea0016p807 | Thyroid | ECE2008

Clinical variables associated with recurrence of hyperthyroidism in Graves’ disease

Cristina Familiar , Inmaculada Moraga , Eva Cruces , Almudena Vicente , Julia Sastre , Jose Lopez

Introduction: In Graves’ hyperthyroidism with long-term antithyroid drugs (ATD) treatment, remission is often umpredictable. However variables at diagnosis or at the end of the ATD regimen are associated with a highest likelihood of recurrence and could be used to decide an ablative treatment.Objective: To identify variables before and at the end of a long-term treatment with ATD (>6 months) associated with higher rates of relapse during a follo...

ea0016p808 | Thyroid | ECE2008

Is pre-ablative thyroglobulin useful as a predictor of cure in differentiated thyroid carcinoma?

Paja Miguel , Oleaga Amelia , Perez Josu , Lizarraga Aitzol , Moreno Cristina , Izuzquiza Ana , Goni Fernando

Surgery followed by 131I ablative therapy (IAT) is the usual treatment for patients with differentiated thyroid carcinoma (DTC). Thyroglobulin levels obtained 9–12 months after IAT under TSH stimulation (Tg2) is a very reliable marker for the presence of thyroid tissue. The value of stimulated thyroglobulin previous to ablation (Tg1) is more controversial. The aim of this study was to examine the relationship between Tg1 and Tg2.Material ...

ea0016p809 | Thyroid | ECE2008

Simultaneous papillary (PTC) and medullary (MTC) thyroid cancer: more than a coincidence? Report of two cases

Oleaga Amelia , Paja Miguel , Nerea Egana , Estibaliz Ugarte , Javier Espiga , Ramon Elorza Jose

The simultaneous occurrence of MTC and PTC in the same thyroid can be observed as a mixed tumour folliculo-medullar (OMS 1988) or as a collision tumour separated by normal thyroid parenchyma, which has only been described in less than thirty patients. We report two cases.Case 1: A 72 years old woman who underwent total thyroidectomy for a multinodular goiter. Histology showed a 2.5 cm CPT in the left lobe and a 4.5 cm CMT in the right lobe. She received ...

ea0016p810 | Thyroid | ECE2008

Effects of rituximab (RTX) treatment on IL-6 and soluble IL-6 receptor secretion in patients with thyroid-associated ophthalmopathy (TAO)

Campi Irene , Vannucchi Guia , Dazzi Davide , Covelli Danila , Bonara Paola , Curro Nicola , Beck-Peccoz Paolo , Salvi Mario

We described a significant clinical response to RTX treatment in patients with active TAO. In order to understand the possible mechanisms of action of RTX, we measured serum concentrations of IL-6 and its soluble receptor (sIL-6R). We treated 10 patients with RTX: 8 women, 2 men aged 31–51 yr with Graves’ disease. We also treated 14 patients with i.v. steroids (IVGC). All had active TAO. In all patients we studied thyroid function, serum autoantibodies and peripheral...

ea0016p811 | Thyroid | ECE2008

Papillary thyroid microcarcinoma in 188 consecutive thyroidectomies

Bayo Juan Angel Hernandez , Sz.-Somoza Monica Belinchon , Monsalve Pablo , Viera Manuel Garcia

Objective: Papillary thyroid microcarcinoma (PTM) is a malignant thyroid tumor with potential multifocality and diameter ≤1 cm. This carcinoma has been discovered more frequently like incidentaloma, and the epidemiology is not clearly established. We have analysed epidemiologic and clinical characteristics in La Palma Island.Patients and methods: We collected all cases of PTM diagnosed in 188 consecutive thyroidectomies performed for whichever caus...

ea0016p812 | Thyroid | ECE2008

Thyroid cancer in a patient with ankylosing spondylitis on infliximab

Athanassiou Panagiotis , Kostoglou-Athanassiou Ifigenia , Gerodimos Charalampos , Dadiras Nikolaos , Batsila Eirini , Kaldrymidis Philippos

Biological agents have been successfully introduced in the therapeutics of autoimmune diseases, in particular rheumatoid arthritis and ankylosing spondylitis. However, their use has been found to increase the risk of serious infections and neoplasms. Infliximab, a neutralizing antibody to tumor necrosis factor-alpha, appears to be effective therapy in ankylosing spondylitis. Tumor necrosis factor (TNF) plays an important role in host defense and tumor growth control. Therefore...

ea0016p813 | Thyroid | ECE2008

Changes in cystatin C during the treatment of subclinical hypothyroidism

Velija-Asimi Zelija , Heljic Becir

Background: Serum cystatin C is a novel marker for kidney function that has been claimed to be superior to serum creatinine. Cystatin C concentrations increased in the hyperthyroid patients and decreased in the hypothyroid patients. The cystatin C test detects kidney disease at earlier stages, before symptoms appear and creatinine levels rise. Another advantage is that, unlike creatinine, blood levels of cystatin C are less influenced by age, gender, race, or lean muscle mass,...

ea0016p814 | Thyroid | ECE2008

Mixed papillary, poorly differentiated and anaplastic thyroid carcinoma

Kostoglou-Athanassiou Ifigenia , Goudouvas Anastasios , Thomas Dimitrios , Bakola Theodosia , Veniou Eirini , Batika Pelagia , Athanassiou Panagiotis , Kaldrymidis Philippos

Well differentiated thyroid carcinoma is associated with prolonged survival in terms of decades and anaplastic carcinoma is associated with survival in months. Intermediate malignancy with a more guarded prognosis is also known to exist.The aim was to describe the case of a patient with a mixed papillary, poorly differentiated and anaplastic thyroid carcinoma.A female patient, aged 73 years presented with a multinodular goiter and ...

ea0016p815 | Thyroid | ECE2008

Prevalence of primary hypothyroidism in an obese population

Souto Selma , Mesquita Joana , Oliveira Ana , Freitas Paula , Correia Flora , Varela Ana , Carvalho Davide , Medina Jose Luis , Braga D

A positive association between thyrotropin (TSH) secretion and body-mass index (BMI) was previously reported. There are many studies concerning thyroid function in obesity, and some of them describe higher TSH levels in obese subjects.Evaluation of the hypothyroidism prevalence in a sample of obese women in their first obesity appointment at Hospital São João.Anthropometric variables and serum levels of TSH, free triiodot...

ea0016p816 | Thyroid | ECE2008

Thyroid autoimmunity and assisted reproductive technology (ART)

Bucci Ines , Guglielmi Marianna , De Vita Maria Grazia , Di Nenno Barbara , Errone Dominique , Giuliani Cesidio , Napolitano Giorgio , Tiboni Giammario , Monaco Fabrizio

About 5–10% of fertile women have anti-thyroid antibodies (AAT); however this prevalence is higher in infertile women. Few studies have been focused so far on the role of thyroid autoimmunity in the outcome of ART. Aims of our studies have therefore been: a) evaluate prevalence of thyroid antibodies in infertile women before ART; b) investigate whether AAT are more prevalent in a specific subset of infertile women; c) investigate the possible influence of AAT or thyroid d...

ea0016p817 | Thyroid | ECE2008

Five new mutations leading to partial deficiency of thyroxine-binding globulin

Moeller Lars C , Vinzelberg Philip , Pohlenz Joachim , Jaeger Andrea , Mann Klaus , Janssen Onno E

Introduction: Thyroxine-binding globulin (TBG) is the main thyroid hormone transport protein in blood. So far, 26 TBG deficiency mutations have been reported, 7 of them leading to partial TBG deficiency. We examined T4 binding capacity and the TBG gene in patients with normal free T4 (fT4) and reduced total T4 (TT4). We present and characterize five new partial TBG deficiency mutations.Methods: Automated chemiluminescence immunoassays were used for the d...

ea0016p818 | Thyroid | ECE2008

Clinical evaluation of 3rd generation assay for thyrotropin receptor autoantibodies in autoimmune thyroid diseases

Schott Matthias , Graeber Claudia , Domberg Julia , Charko Roswitha , Hermsen Derik , Schinner Sven , Scherbaum Werner A , Willenberg Holger S

Recently a new procedure for measuring serum TSH receptor (TSHR) autoantibody (TRAb) was reported in which the autoantibodies inhibit binding of a human monoclonal thyroid stimulating antibody M22 (labeled with biotin) to TSHR-coated ELISA plate wells. This assay was termed 3rd generation TRAb assay. The aim of the present study was to clinically evaluate the TRAb 3rd generation assay in comparison with the 2nd generation TRAb assay (TRAb-2nd) based on the recombinant human TS...

ea0016p819 | Thyroid | ECE2008

First rapid and automated immunoassay for TSH receptor antibodies

Gassner Dieter , Golla Ruth , Stock Werner , Sanders Jane , Smith Bernard Rees

Hyperthyroidism in Graves’ disease is due to TSH receptor (TSHR) autoantibodies (TRAb) directed against the TSH binding pocket. Detection of TRAb in clinical rou-tine is performed by 2nd gen assays using human or porcine TSHR. Such TSH bin- ding inhibition immunoglobulin (TBII) assays determine the ability of TRAb to inhi- bit the binding of labelled TSH to immobilized TSHR. TRAb are present in low con- centrations and mostly recognize conformational epitopes. The conform...

ea0016p820 | Thyroid | ECE2008

Visual evoked potentials in children with hypothyroidism

Zak Teresa , Noczynska Anna , Klempous Joanna , Pilecki Witold , Szawronowicz Teresa

The clinical picture of hypothyroidism is well described. It is well known that thyroid hormones are very important to development and maturation of the central nervous system. They have influence on the synthesis of proteins and production of enzymes and myelin.Myelin synthesis is an important factor in determining the speed of impulse transmission along complex polysynaptic pathways, such as those mediating the evoked potentials....

ea0016p821 | Thyroid | ECE2008

Iodothyronine antibodies are not correlated with prevalence or prognosis of non-thyroidal illness syndrome

Dietrich Johannes W , Ackermann Antje , Jeyabalan Abira , Kunanayagam Yarlini , Tharmalingam Tabotnini , Urban Aline , Stachon Axel , Klein Harald H , Hering Steffen

Patients suffering from critical illness usually exhibit a characteristic functional state of thyrotropic feedback control that is referred to as non-thyroidal illness syndrome (NTIS). Today, there are still important questions unsolved, e.g. regarding the interdependence of immunological and endocrine functions in critical illness.Therefore, in the context of the prospective AQUA FONTIS study we investigated 164 patients that were treated in medical, su...

ea0016p822 | Thyroid | ECE2008

No association between BRAFV600E and metalloproteinase activity in anaplastic thyroid cell lines

Carissimi Elvira , Bommarito Alessandra , Pizzolanti Giuseppe , Zito Giovanni , Richiusa Pierina , Russo Leonardo , Coppola Antonina , Smeraldi Lucia , Galluzzo Aldo , Giordano Carla

A strong evidence suggests the role of BRAFV600E mutation in determining the aggressiveness of thyroid cancer. To detect how the association of BRAF mutation could influence the aggressiveness of particular subtypes of thyroid tumors, we analysed a possible correlation between BRAFV600E and metalloproteinase (MMPs) activity, as its enhanced production could be an important determinant of tumor invasion. For this purpose, we investigated the activity and t...

ea0016p823 | Thyroid | ECE2008

Analysis of selected adipocytokines in children with autoimmune thyroid diseases

Bossowski Artur , Sawicka Beata , Urban Miroslawa , Skrzydlo Marcin , Szalecki Mieczyslaw

Leptin, adiponectin and resistin play an essential role in regulation of body mass, which is controlled by thyroid hormones levels.The aim of the study was to evaluate leptin, adiponectin and resistin levels in young patients with Graves’ disease and in children with Hashimoto’s thyroiditis.The study group formed 78 patients suffering from Graves’ disease (30 girls and 2 boys; aged from 6 to 21- mean 15.2 years) and ...

ea0016p824 | Thyroid | ECE2008

Moderate hyperhomocysteinemia in hypothyroidism

Ursu Horea , Purice M , Alexiu F

Moderately elevated plasma homocysteine levels (>12 μmol/l) are highly prevalent in the general population and are associated with an increased risk for cardiovascular disease. Homocysteine is an amino acid produced during catabolism of the essential amino acid methionine. Metabolism of homocysteine requires an adequate supply of folic acid, vitamin B12 and vitamin B6.Moderate hyperhomocysteinemia may be caused by a variety of factors: chronic d...