Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 16 | ECE2008 | Next issue

10th European Congress of Endocrinology

Symposia

Addicted to food?

ea0016s12.1 | Addicted to food? | ECE2008

The Selfish brain: competition for energy resources

Peters Achim

The brain takes a primary position in the organism. We present the novel view that the brain gives priority to controlling its own adenosine triphosphate (ATP) concentration. It fulfils this tenet by orchestrating metabolism in the organism. The brain activates an energy-on-request system that directly couples cerebral supply with cerebral need. The request system is hierarchically organized among the cerebral hemispheres, the hypothalamus, and peripheral somatomotor, autonomi...

ea0016s12.2 | Addicted to food? | ECE2008

Peptide YY: cure for obesity?

Batterham Rachel

Exogenous administration of the gut hormone peptide YY3-36 (PYY3-36) reduces food intake in obese humans and rodents. New lines of evidence support a role for endogenous PYY3-36 in regulating energy homeostasis. The NPY-Y2 receptor mediates the anorectic actions of PYY3-36 with rodent studies implicating the hypothalamus, vagus and brainstem as key target sites. Functional imaging in humans has confirmed that PYY3-36 activates brainstem and hypothalamic regions. The greatest e...

ea0016s12.3 | Addicted to food? | ECE2008

Hypothalamic regulation of energy balance

Cota Daniela

Obesity and its consequences, such as type-2 diabetes, cardiovascular disease and cancer, are serious health threats. However, despite what the obesity epidemic might suggest, the balance between caloric intake and expenditure is regulated with tremendous precision under most circumstances. Thus, a regulatory system exists, where deviations from the defended body adiposity level trigger signals that can be monitored by specific intracellular metabolic pathways. Such pathways a...

ea0016s12.4 | Addicted to food? | ECE2008

Metabolic and reward cues affect the central clock in the brain

Challet Etienne , Mendoza Jorge

Daily rhythmicity in neuroendocrine functions and sleep-wake cycle is controlled by an endogenous circadian timing system, organized in a network of oscillatory structures. At the top of this circadian multi-oscillatory network, there is a master clock located in the suprachiasmatic nuclei of the hypothalamus. The molecular clockwork involves various clock genes, such as Period (Per).Light is the most potent synchronizer of the suprachiasmatic clock. By ...