Searchable abstracts of presentations at key conferences in endocrinology
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10th European Congress of Endocrinology

Symposia

Nuclear receptors

ea0016s8.1 | Nuclear receptors | ECE2008

LXR

Saez E

Abstract unavailable...

ea0016s8.2 | Nuclear receptors | ECE2008

Kinase signaling and retinoic acid nuclear receptors

Rochette-Egly Cecile

It is well established that nuclear retinoic acid (RA) receptors (RARα, RARβ and RARγ) activate gene expression through a complex and evergrowing network of dynamic interactions with coregulatory protein complexes, which are coordinated by the ligand.Adding more complexity to this scenario, we demonstrated that RARs are also targets for phosphorylation processes, which govern their transcriptional activity in cooperation with the ligand. I...

ea0016s8.3 | Nuclear receptors | ECE2008

Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation

Metzger Eric , Yin Na , Wissmann Melanie , Kunowska Natalia , Friedrichs Nicolaus , Patnaik Debasis , Higgins Jonathan M G , Potier Noelle , Scheidtmann Karl-Heinz , Buettner Reinhard , Schule Roland

Post-translational modifications of histones such as methylation, acetylation, and phoshorylation regulate chromatin structure and gene expression. However, phosphorylation of histone H3 at threonine 11 (H3T11ph) has not been linked to transcriptional regulation. Here we show that protein kinase C-related kinase 1 (PRK1) phosphorylates H3T11 upon ligand-dependent recruitment to androgen receptor (AR) target genes. PRK1 is pivotal to AR function since PRK1 knockdown by RNAi or ...

ea0016s8.4 | Nuclear receptors | ECE2008

Estrogen-related receptors as regulators of energy homeostasis and adaptive metabolism

Villena Josep Villena , Hock Ben , Hazen Bethany , Giguere Vincent , Kralli Anastasia

Adaptation of oxidative metabolism is essential for meeting different energy demands in different tissues, or altered energy demands in response to stressors, such as exposure to cold. The orphan nuclear receptor ERRα (estrogen-related receptor alpha) is implicated in the regulation of energy metabolism. ERRα expression is high in tissues with high oxidative capacity and increased at physiologic states of increased energy demand. Moreover, ERRα activity and expr...