ea0016s23.4 | Towards a better understanding of hypothalamic–pituitary disorders | ECE2008
, Garcia-Lavandeira Montse
, Dieguez Carlos
, Alvarez Clara
, Malumbres Marcos
The importance of cell cycle regulation in pituitary biology has been suggested from the fact that many gene-targeted mouse models of cell cycle mutations develop diverse pituitary pathologies. The retinoblastoma protein (pRb)/cyclin-dependent kinase 4 (Cdk4) pathway, one of the major mitogen-sensor routes in the cell, seems to be critical in the control of pituitary cell proliferation. Both inactivation of pRb or hyperactivation of Cdk4 result in pituitary hyperplasias or tum...