ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2008) 16 P227

The association between adipocytokine profiles and insulin resistance in obese subjects

Omar Al-Attas1, Nasser Al-Daghri1 & Reem Sallam2

1King Saud University, Riyadh, Saudi Arabia; 2King Khalid University Hospital, Riyadh, Saudi Arabia.

This study aims to explore the baseline adipocytokine profiles of adult Saudis and evaluate their relationship in the development of insulin resistance. Three hundred adult Saudis with varying glucose tolerance were recruited. They were grouped into NGT, IGT and DM. Anthropometrics, glucose and lipid profiles were analyzed by routine methods; leptin, adiponectin, resistin and CRP were measured by ELISA. Insulin resistance was significantly correlated with levels of CRP (R 0.32, P=0.02) in the NGT; with leptin levels (R 0.46, P=0.001) in the IGT; and with adiponectin levels (R 0.25, P=0.001) in all groups. In males, resistin and CRP exhibited significant correlations to insulin resistance (R 0.33, P=0.005); in females significant correlation was demonstrated between insulin resistance and adiponectin (R 0.32, P=0.003). Significant associations exist in the adipocytokine profiles of adults with different glucose tolerance. Certain adipocytokines can be used not only as promising markers but as potential adjunct therapy with regards to insulin sensitivity and obesity.

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