Endocrine Abstracts (2008) 16 P232

Severity of depression in patients with type 1 and type 2 diabetes and its relation to the level of glycemia control and anti-depressive therapy

Liana Tsutskiridze, Ramaz Kurashvili, Natalia Asatiani, Givi Kurashvili, Maia Khelashvili, Maia Nishnianidze, Elena Shelestova & Mzia Dundua


Georgian Diabetes Center, Tbilisi, Georgia.


Background and aims: There are consistent findings about increased prevalence of depressive disorders in diabetes. The aim of the study was to reveal prevalence of depression in patients (pts) with type 1 (DM1) and type 2 (DM2) diabetes.

Materials and methods: Totally, 157 pts with DM were questioned. To assess depression degree Beck’s scale was used, and 83 depressive pts (scores>10), were allocated into 2 groups (Gr.): Gr.1 (n=44)-DM2 pts (m20/f24), mean age 57.5±8.4 years, diabetes duration 6±2 years, HbA1c-8.8±1.3%, Gr. 2 (n=39)–DM1 pts (m16/f23), mean age 30±5 years, diabetes duration-7±2 years, HbA1c-9.2±1.9%. Assessment scores: Gr.1 (m) >55 (7 pts/35%), 30–50 (8 pts/40%), ≥10 (5 pts/25%); (f) >60 (11 pts/45.8%), 30–50 (8 pts/33.4%), >15 (5 pts/20.8%). Gr.2(m) >50 (8 pts/50%), 30–50 (7 pts/43.7%), ≥10 (1 pts/6.25%); (f) >60 (12/52.2%), 30–50 (8/34.8%), >20 (3/13%). Eighteen Gr.1 pts were treated with insulins and oral hypoglycemic agents (OHAs); 26-only with OHAs. Intensive insulin therapy was used in 22 Gr.1 pts. Tianeptin 3 tablets/daily was used for depression treatment in both groups.

Results: Repeated examination at month 3 post study initiation showed: HbA1c dropped by 7.3±0.9%; P=0.000 (Gr.1), and by 6.5±0.6%; P=0.000 (Gr.2). Beck’s scores were: Gr.1 (m): 30–40 (7 pts), 20–30 (8 pts), 0 (5 pts); (f): 50–60 (11 pts), 20–30 (8 pts), ≥10 (5 pts). Gr.2 (m): 30–40 (8 pts), ≥20 (7 pts), 0 (1 pts); (f): 50–60 (12 pts), 20–25 (8 pts), ≥8 (3 pts). At entry there was no statistically evident difference in depression severity between the groups (P=0.177; P=0.537, respectively). Post treatment there was statistically evident correlation between decline in HbA1c levels and depression severity in both groups, this evidence was relevant for males and females: Gr.1 (m) r=0.948, P=0.000; (f) r=0.909, P=0.000. Gr.2 (m) r=0.915, P=0.000; (f) r=0.921, P=0.000.

Conclusion: We conclude: (1) There was no statistically evident difference in depression severity between the DM types. (2) There is statistically evident post-treatment correlation between glycemia control level and depression degree in both groups.

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