Endocrine Abstracts

Metabolic syndrome is risk factor for cardiovascular event. According recommendation of NCEP ATP III, the major component of metabolic syndrome is waist circumference up to 94 cm in male and 80 cm in female, and two of following disturbances: fasting glucose up to 5.6 mmol/l, HDL below 0.9 in male and 1.3 in female, triglycerides up to 1.7 mmol/l and BP up to 135/80 mmHg.

We have analyzed the influence of low calorie diet (1200–1500 kcal/day) with increased dietary fibers of 25–40 g/day and the macronutrients ratio: fats 22–23%, proteins 15–18% and carbohydrates 55–65%. 95 subjects divided into two groups took part in this investigation. Examined group was treated with recommended diet and control group was treated with standard low calorie diet with dietary fibers of 10–15 g/day, carbohydrates 35–45%, fats 20–30% and proteins 20–25%.

After 6 months waist circumference decrease significantly (P=0.001) in examined group, and non significantly increased in control group (P=0.17). Fasting glucose decreased high significantly in examined group, and there was no changes in control group. HDL in examined group significantly increased (P<0.05) while in control group there was no changes (P>0.05). Triglycerides and systolic blood pressure decreases significantly in examined group (P=0.001), but control group had more significant decrease of diastolic blood pressure (P<0.05).

These results suggest positive effect of low calorie diet on the parameters of the metabolic syndrome. The reductions of total and saturated fats, balanced protein and carbohydrates intake and increased intake of dietary fibers have positive influence on the lipid profile and improve glycemic regulation in obese people with metabolic syndrome.