Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2008) 16 P486

ECE2008 Poster Presentations Obesity (94 abstracts)

The effect of various dyslipidemia management guidelines on the assessment of LDL-C goal attainment in population-based studies

Pendar Farahani


McMaster University, Hamilton, ON, Canada.


Drug therapies are effective for improving lipid profiles. However, a large proportion of patients and specifically high-risk patients appear unable to achieve the recommended goals for LDL-C level. Furthermore, the proportions of patients, who lack the targeted LDL-C goal, are inconsistent among different studies.

Objectives: To explore if application of different guidelines for the management of dyslipidemia can influence the proportion of LDL-C target level achievement in a population level.

Methods: To assess the attainment of LDL-C goal, data from a Canadian community-based (CCB) study (Clin Invest Med 2007 30 E63–E69) were evaluated against three guidelines: the 2003 Canadian guideline for management of dyslipidemia, the NCEP-APT guideline and AFSSAPS guideline. These result were also compared with goal attainment observed in other studies, including CALIPSO (Canada), L-TAP (USA), EUROASPIRE (Europe), OLYMPIC (Greece), REALITY-PHARMO (The Netherlands), BKL-Thales (France).

Results: Using the Canadian guideline, only 73% of patients in CCB study achieved the goal for LDL-C level. About 96% of low risk and 62% of high risk patients achieved the LDL-C goal. Similar results were obtained when data from the CALIPSO study were used. Conversely, the CCB study demonstrated a significantly different attainment of LDL-C targets compared with the studies from Europe and the United States that used the NCEP-APT guideline or AFSSAPS guideline to set the LDL-C target levels.

Conclusion: Several factors may contribute to the observed inter- country differences in goal attainment, including different patient populations, different clinical practice guidelines and different time frame when the results were obtained.

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