Introduction: This study carried out relationship between glomerulary filtration rates (GFR) and various metabolic parameters in obese women.
Materials and methods: Selected subjects recruited retrospectively from outpatient clinic for this study were 5115 overweight or obese women with mean GFR which was 93 ml/dk/1.73 m2 calculated by MDRD (modification of diet in renal disease). According to mean GFR, they divided group I (low GFR) having ≤92 ml/dk/1.73 m2 and group II (normal GFR) having >93 ml/dk/1.73 m2. Thereafter, we determined and compared body compositions (body mass index, abdominal fat mass), resting blood pressures, plasma lipoprotein levels, glucose homeostasis and other related biochemical parameters.
Results: Calculated GFR were 74.2±10.8 ml/dk/1.73 m2 in low GFR group (n=2555, 49.9%) and 110.8±34.1 ml/dk/1.73 m2 in normal GFR group (n=2560, 50.1%). Mean age, BMI, body fat mass, systolic and diastolic blood pressures, fasting glucose, fasting insulin, HOMA values, total cholesterol, LDL-cholesterol, triglycerides, uric acid and high sensitive C-reactive protein levels, counts of leukocytes, liver transaminases except aspartate transaminases activity were significantly higher in low GFR group than normal GFR group (P<0.05). But mean waist circumferences, abdomal fat mass and ferritin levels were not different between groups (P>0.05; Table 1).
|Low GFR group (n=2560)||Normal GFR group (n=2555)||P values|
|Waist circumferences (cm)||100.68±13.55||100.32±19.50||NS|
|Total cholesterol (mg/dl)||213.79±45.49||197.55±39.70||<0.001|
Discussion: In obese women, reduction in GFR was associated with metabolic, cardiovascular and renal end points. It should be careful during a slimming program with included GFR in obese or overweight women.
03 - 07 May 2008
European Society of Endocrinology