Endocrine Abstracts (2008) 16 P820

Visual evoked potentials in children with hypothyroidism

Teresa Žak, Anna Noczyńska, Joanna Klempous, Witold Pilecki & Teresa Szawronowicz


Department of Endocrinology and Diabetology for Children and Adolescents, Wroclaw, Poland.


The clinical picture of hypothyroidism is well described. It is well known that thyroid hormones are very important to development and maturation of the central nervous system. They have influence on the synthesis of proteins and production of enzymes and myelin.

Myelin synthesis is an important factor in determining the speed of impulse transmission along complex polysynaptic pathways, such as those mediating the evoked potentials.

Visual evoked potentials are reliable and objective method for measuring the function of visual pathway conduction. Visual Evoked Potentials (VEP) were performed in 40 children. We studied 26 girls and 14 boys. The flash stimulation with frequency of 1 Hz was used.

At the time of the present study patients were euthyroid with no clinical signs of disease.

The latencies to the peak P100 were measured. We compared the results with normal control group of 35 children (21 girls and 14 boys). The recording of VEP is a sensitive technique for detection of subclinical lesions of the visual system.

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