Serum levels of soluble RAGE (sRAGE total), the soluble isoform of the receptor of advanced glycated end products (AGEs) that lacks the transmembrane and intracytoplasmic domains of RAGE, has been found elevated in type 2 diabetics and non diabetic subjects and positively correlated with AGEs levels. In women with PCOS, while serum AGEs have been demonstrated to be elevated, sRAGE levels have not been determined as yet.
The aim of the present study was to determine sRAGE serum levels in PCOS women compared with the levels in healthy controls and investigate the potential associations of sRAGE with metabolic and endocrine parameters in PCOS women. The study was approved by the local ethical committee.
Fifty-one non diabetic reproductive-aged women with PCOS (defined by Rotterdam criteria), receiving no medical treatment and 10 controls were studied. sRAGE, AGEs, androgen, estradiol serum levels and homeostatic assessment model (HOMA) were determined. Women with PCOS compared with controls of similar age and body mass index (BMI) had significantly increased sRAGE levels (677.1±51.57 vs 475.6±22.69 pg/ml, P=0.019), which were correlated positively with AGEs levels (r=0.533, P=0.009). sRAGE levels did not correlate with BMI, androgen levels and HOMA.
These data demonstrate, for the first time, that non diabetic PCOS women have increased levels of sRAGE, which correlate positively with AGEs levels, but are independent of obesity, hyperandrogenemia and insulin resistance. The role of elevated serum sRAGE levels, in PCOS remains to be explored.