FNH is the second most common benign liver tumor caused mainly by oral contraceptives. D1, which is a crucial enzyme in catalyzing prohormone thyroxine (T4) into active triiodothyronine (T3), is mainly present in such tissues as thyroid, liver and kidney. There are only few data about D1 enzymatic activity in neoplasmatic conditions. Mostly in tumors reduced D1 activity was found.
The aim of the study was to examine the activity of this enzyme in FNH.
Thirteen samples of the tumor and the corresponding number of healthy control tissues were collected from the patients, who underwent the surgery because of that disease. Average age was 28.3. We assessed the activity by measurement of radioactive iodine released in deiodination reaction catalyzed by D1.
We found that D1 enzymatic activity is not reduced in FNH in comparison with healthy controls (P=0.555). Our finding demonstrates that not every type of neoplasm presents low D1 activity.
03 - 07 May 2008
European Society of Endocrinology