ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2008) 16 P51

Adrenocortical changes and arterial hypertension in lipoatrophic A-ZIP/F-1 mice

Valeria Lamounier-Zepter1, Stefan Bornstein1, Jaroslav Kunes2, Jozef Zicha2, Michal Krsek3, Monika Ehrhart-Bornstein1, Christian Ziegler1, Andrea Kiessling1, Richard Funk1 & Martin Haluzik3


1University Medical Center, Dresden, Germany; 2Institute of Physiology AS CR and Center for Experimental Research of Cardiovascular Diseases, Prague, Czech Republic; 31st Faculty of Medicine, Prague, Czech Republic.


The A-ZIP/F-1 transgenic mouse is a model of lipoatrophic diabetes with severe insulin resistance, hyperglycemia and hyperlipidemia. Recently, a regulatory role of adipose tissue on adrenal gland function and blood pressure has been suggested. To further explore the importance of adipose tissue in the regulation of adrenal function and blood pressure, we studied this mouse model of lipodystrophy. A-ZIP/F-1 mice exhibit significantly elevated systolic and diastolic blood pressure values despite lack of white adipose tissue and its hormones. Furthermore, A-ZIP/F-1 lipoatrophic mice have a significant reduction of adrenal zona glomerulosa, while plasma aldosterone levels and aldosterone synthase mRNA expression remain unchanged. On the other hand, lipoatrophic mice present elevated corticosterone levels but no adrenocortical hyperplasia. Ultrastructural analysis of adrenal gland show significant alterations in adrenocortical cells, with conformational changes of mitochondrial internal membranes and high amounts of liposomes. In conclusion, lipodystrophy in A-ZIP/F-1 mice is associated with hypertension, possibly due to hypercorticosteronemia and/or others metabolic-vascular changes.