Endocrine Abstracts (2008) 16 P518

Glomerular filtration rates as a cardiometabolic risk markers in obese women

Taner Bayraktaroglu1, Faruk Kutlutürk2, Adil Dogan Azezli3 & Yusuf Orhan3


1Zonguldak Karaelmas University, Faculty of Medicine, Endocrinology and Metabolism, Zonguldak, Kozlu, Turkey; 2Gazi Osman Pasa University, Faculty of Medicine, Endocrinology and Metabolism, Tokat, Turkey; 3Istanbul University, Istanbul Faculty of Medicine, Endocrinology and Metabolism, Istanbul, Fatih/Capa, Turkey.


Introduction: This study carried out relationship between glomerulary filtration rates (GFR) and various metabolic parameters in obese women.

Materials and methods: Selected subjects recruited retrospectively from outpatient clinic for this study were 5115 overweight or obese women with mean GFR which was 93 ml/dk/1.73 m2 calculated by MDRD (modification of diet in renal disease). According to mean GFR, they divided group I (low GFR) having ≤92 ml/dk/1.73 m2 and group II (normal GFR) having >93 ml/dk/1.73 m2. Thereafter, we determined and compared body compositions (body mass index, abdominal fat mass), resting blood pressures, plasma lipoprotein levels, glucose homeostasis and other related biochemical parameters.

Results: Calculated GFR were 74.2±10.8 ml/dk/1.73 m2 in low GFR group (n=2555, 49.9%) and 110.8±34.1 ml/dk/1.73 m2 in normal GFR group (n=2560, 50.1%). Mean age, BMI, body fat mass, systolic and diastolic blood pressures, fasting glucose, fasting insulin, HOMA values, total cholesterol, LDL-cholesterol, triglycerides, uric acid and high sensitive C-reactive protein levels, counts of leukocytes, liver transaminases except aspartate transaminases activity were significantly higher in low GFR group than normal GFR group (P<0.05). But mean waist circumferences, abdomal fat mass and ferritin levels were not different between groups (P>0.05; Table 1).

Table 1
Low GFR group (n=2560)Normal GFR group (n=2555)P values
Age (year)43.47±11.9337.31±11.63<0.001
BMI (kg/m2)36.42±6.9335.74±6.90<0.001
Waist circumferences (cm)100.68±13.55100.32±19.50NS
HOMA3.81±4.953.32±4.170.008
Total cholesterol (mg/dl)213.79±45.49197.55±39.70<0.001
Triglycerides (mg/dl)162.66±126.98134.46±113.34<0.001

Discussion: In obese women, reduction in GFR was associated with metabolic, cardiovascular and renal end points. It should be careful during a slimming program with included GFR in obese or overweight women.

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