Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2008) 16 P614

1Department of Physiology, University of Santiago de Compostela, Santiago de Compostela/A Coruña, Spain; 2Departments of Physiology and Pediatrics, University of Turku, Turku, Finland; 3Department of Cell Biology, Physiology and Immunology, University of Córdoba, Cordoba, Spain; 4CIBER (CB06/03) Fisiopatología de la Obesidad y Nutrición, Instituto Salud Carlos III, Madrid, Spain; 5Department of Physiology and Genetic Institute, Faculty of Medicine, National University of Colombia, Bogota, Colombia; 6Endocrine Department, Hospital Juan Canalejo, A Coruña, Spain.


The adipose tissue is an active endocrine organ involved in the control not only of metabolism and energy balance, but also of other relevant body functions, including reproduction. Adiponectin is an adipocyte hormone, with relevant roles in lipid metabolism and glucose homeostasis, recently involved in the control of different endocrine organs, such as the placenta, pituitary and, likely, the ovary. However, whether as described previously for other adipokines, such as leptin and resistin, adiponectin is expressed and/or conducts biological actions in the male gonad remains unexplored. In this study, we provide compelling evidence for the expression, putative hormonal regulation and direct effects of adiponectin in the rat testis. Testicular expression of adiponectin was demonstrated along postnatal development, with a distinctive pattern of RNA transcripts and discernible protein levels that appeared mostly located at interstitial Leydig cells. Testicular levels of adiponectin mRNA were marginally regulated by pituitary gonadotropins, but overtly modulated by metabolic signals, such as glucocorticoids, thyroxine and the PPAR-γ ligands. In addition, expression of the genes encoding adiponectin receptor 1 (AdipoR1) and AdipoR2 was detected in rat testis, with developmental changes and gonadotropin regulation for AdipoR2 mRNA, and prominent levels of AdipoR1 in seminiferous tubules. Moreover, recombinant adiponectin significantly inhibited basal and human CG-stimulated testosterone secretion ex vivo, while it failed to change relative levels of several Sertoli cell-expressed mRNAs, such as stem cell factor and anti-müllerian hormone. In sum, our data are the first to document the expression, regulation and functional role of adiponectin in rat testis. Taken together with its recently reported expression in the ovary and its effects on luteinizing hormone secretion and ovarian steroidogenesis, these results further substantiate a multi-faceted role of adiponectin in the control of the reproductive axis, which might operate as endocrine integrator linking metabolism and gonadal function.

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