ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2008) 16 P644

The incidence of adiponectin gene polymorphism and its relation to serum adiponectin and androgen levels, insulin resistance and clinical parameters in polycystic ovary syndrome

Hüseyin Demirci1, Erkan Yurtcu2, Murat Yilmaz3, Göksun Ayvaz1, M Ali Ergün2 & Metin Arslan1

1Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey; 2Department of Medical Genetic, Gazi University Faculty of Medicine, Ankara, Turkey; 3Department of Endocrinology and Metabolism, Bilim University Faculty of Medicine, Istanbul, Turkey.

Aim: The present study was designed to examine the relationship between adiponectin gene (T45G in exon 2) polymorphism and clinical and hormonal characteristics in women with polycystic ovary syndrome (PCOS).

Materials and methods: Ninety-six patients with PCOS and 93 healthy subjects were included in the study. Serum levels of sex steroids, insulin and adiponectin levels were measured. Insulin resistance was evaluated by homeostasis model assessment (HOMA). We used the PCR to examine adiponectin gene T45G polymorphism.

Results: Serum adiponectin levels lower in PCOS patients than control group. There was no statistically significant difference in the incidence of gene polymorphism and genotype distribution between PCOS and control groups. We have shown that polymorphism of T45G adiponectin gene in exon 2 is not related to clinical findings, antropometric parameters, increased serum androgen levels and decreased adiponectin levels in PCOS. Nevertheless, fasting insulin level and insulin resistance were significantly higher in polymorphic group.

Conclusion: Our study suggests that adiponectin gene T45G polymorphism is not related the phenotypic features of PCOS but it plays an important role in the development of insulin resistance in the PCOS.

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