Aim: The present study was designed to examine the relationship between adiponectin gene (T45G in exon 2) polymorphism and clinical and hormonal characteristics in women with polycystic ovary syndrome (PCOS).
Materials and methods: Ninety-six patients with PCOS and 93 healthy subjects were included in the study. Serum levels of sex steroids, insulin and adiponectin levels were measured. Insulin resistance was evaluated by homeostasis model assessment (HOMA). We used the PCR to examine adiponectin gene T45G polymorphism.
Results: Serum adiponectin levels lower in PCOS patients than control group. There was no statistically significant difference in the incidence of gene polymorphism and genotype distribution between PCOS and control groups. We have shown that polymorphism of T45G adiponectin gene in exon 2 is not related to clinical findings, antropometric parameters, increased serum androgen levels and decreased adiponectin levels in PCOS. Nevertheless, fasting insulin level and insulin resistance were significantly higher in polymorphic group.
Conclusion: Our study suggests that adiponectin gene T45G polymorphism is not related the phenotypic features of PCOS but it plays an important role in the development of insulin resistance in the PCOS.
03 - 07 May 2008
European Society of Endocrinology