Endocrine Abstracts (2008) 16 P729

Valuation of iodine deficiency in Western Andalusia by means of the neonatal screening of congenital hypothyroidism

Juan Manuel Garcia-Quiros, Cristobal Morales, Silvia Maraver, Guillermo Martinez de Pinillos, Monica Tome, Carmen Cuesta, J M Guerrero & Angel Sendon


Virgen Macarena Hospital, Seville, Spain.


Introduction: The accomplishment of screening neonatal congenital hypothyroidism allows the use of the determination of TSH in new born (NB) like indirect marker of the iodine ingestion of the pregnant woman and the nutritional iodine deficiency in the population. In populations with a sufficient iodine ingestion, the proportion of children with TSH superior to 5 U/ml is smaller of 3%.

Primary target: To make the iodine deficiency map in the studied area (western Andalusia).

Method: The NB studied were selected by measuring TSH levels in heel dry blood from the provinces of Cadiz, Huelva and Seville during years 2000–2004 (188, 616 RN).

The percentage will take shelter of NB that in each population has a value of TSH>5 uU/ml., indicative according to the WHO/UNICEF/ICCIDD of iodine deficiency. It was used only samples of heel with a stagger between the birth and extraction of >48 h to avoid the slant of confusion of transitory physiological TSH elevation.

Results: Percentage of RN with TSH>5 μU/ml (we frequently presented/displayed in the single summary the ZBS>3%)

PROV. HUELVA 4.11%

 DISTRICT COUNTY COUNTRYSIDE 2.72%

 DIST. HUELVA COST 4.55%

 DIST. MOUNTAIN RANGE OF CENTRAL HUELVA ANDEVALO 12.50%

PROV. SEVILLE 1.06%

 DIST.ALJARAFE 1.19%

 DIST SEVILLE CITY 1.20%

 DIST EAST SEVILLE AREA OSUNA 0.74%

 DIST NORTH SEVILLE 0.83%

 DIST SOUTH SEVILLE 0.94%

PROV. CADIZ 2.48%

 DIST BAY OF CADIZ JANDA 2.10%

 DIST FIELD OF GIBRALTAR 1.76%

 DIST SHERRY COSTA NE 3.56%

 DIST MOUNTAIN RANGE OF CADIZ 2.90%

CEUTA 1.85%

MELILLA 8.94%

Conclusions: Zones of iodine deficiency still exist in western Andalusia which means that a sanitary intervention is necessary to prevent the upheavals associated to this situation in order to its clinical importance.

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