Endocrine Abstracts (2008) 16 P774

The variation intercellular adhesion molecule-1 level in primer and postoperative hypothyroid patients with treatment

Mesut Ozkaya1, Erman Cakal2 & M Fatih Yuzbasioglu3

1Department of Endocrinology and Metabolism, Sutcu Imam University Medical Faculty, Kahramanmaras, Turkey; 2Department of Endocrinology and Metabolism, Yuksek Ihtisas Hospital, Ankara, Turkey; 3Department of General Surgery, Sutcu Imam University Medical Faculty, Kahramanmaras, Turkey.

Background and aims: It is reported that intracellular adhesion molecule-1 (ICAM-1) is important in autoimmune thyroid diseases also it is an important point that ICAM-1 level is high in postoperative hypothyroid cases. In literature, it is said that the level of plasma soluble ICAM-1 can be used as a evidence immune system activation and inflammation, and also it can be used for the diagnosis of some inflammatory and autoimmune diseases. The aim of our was to compare the level of ICAM-1 in hypothyroid cases who have different ethiologic origins and was to investigate the among treatment variation.

Material and methods: Sixteen primer hypothyroidism, 16 postoperative hypothyroidism, totally 32 female patients were chosen for the study and also 16 healthy, no past and familiar disease were chosen as a control group. The patients who have type 2 diabetes, who have inflammatory and infectious disease and smokers were left from this group when it’s diagnosed in patients and control groups and when the level of TSH is normal biochemical fast parameters and level of ICAM-1 was calculated.

Results: Primer hypothyroid, postoperative hypothyroid and control groups were approximately similar for age (38.6±7.3, 38.0±7.3, 40.6±6.3). And also body mass index was similar in patient and control groups the level of beginning ICAM-1 level in postoperative hypothyroid patients was found higher than control group (46.6±10.7, 27.1±2.3, P<0.001). When two hypothyroid group were compared the level of ICAM-1 was found really high in primer hypothyroid group (46.6±10.7, 39.4±5.1, P<0.05). In both groups, the level of euthyroid ICAM-1 was found very high than the beginning datas (46.6±10.7, 51.3±10.5, P<0.001, 39.4±5.1, 45.3±6.8, P<0.001).

Conclusion: ICAM-1 level can be used for investigating hypothyroid cases. The level of ICAM-1 is increasing in hypothyroid cases with the treatment. The level of ICAM-1 can be used as a effectiveness parametria in hypothyroid cases.

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