Endocrine Abstracts (2008) 16 P787

Should we look for metabolic syndrome (MSy) in subclinical hypothyroidism?

Milka Drezgic, Ljiljana Marina, Miomira Ivovic, Milina Tancic-Gajic, Milos Stojanovic, Marija Barac & Svetlana Vujovic


Institute of Endocrinology, Diabetes and Metabolic Disorders, Belgrade, Serbia.


Subclinical hypothyroidism is a biochemical diagnosis defined with elevated levels of TSH and normal levels of thyroid hormones. The most common abnormality linked to this condition is hypercholesterolemia. The aim of this study was to search for MSy among the persons with subclinical hypothyroidism which was already proven to have hypercholesterolemia when compared to healthy control. MSy was identified in those with elevated triglycerides (Tgc), reduced HDL and elevated fasting glucose. We compared each of these parameters as well as the presence of MSy in patients with subclinical hypothyroidism to age and BMI matched healthy control. We evaluated 60 persons in two groups: 1st group: 38 patients (35 women and 3 men) with subclinical hypothyroidism, mean age 48.63±9.88 years, mean BMI 26.19±6.17 kg/m2, with laboratory proven subclinical hypothyroidism. Second group: 22 healthy euthyroid controls, mean age 49.14±10.32 years, mean BMI 26.67±4.57 kg/m2. None of them had a history of coronary heart disease, signs of liver and/or renal dysfunction or were previously treated with lipid lowering drugs. Statistical analysis was performed with t-test and Mann–Whitney U-test. In the 1st group, mean Tgc level was 2.22±1.74 mmol/l, mean HDL level was 1.23±0.45 mmol/l and mean fasting glucose level was 5.21±0.92 mmol/l. In the 2nd group, mean Tgc level was 1.36±0.42 mmol/l, mean HDL was 1.39±0.35 mmol/l and mean fasting glucose was 4.63±0.41 mmol/l. There was a high statistical difference between the level of tgc between the groups (P<0.01). For the level of fasting glucose, there was a statistical difference (P<0.05). For the levels of HDL and the overall presence of MSy between the groups there was no statistical difference (P>0.05). Eventhough there was no difference in HDL levels and no difference in the overall presence of MSy between the groups we think that along with hypelipidemia MSy is something to think about in subclinical hypothyroidism.

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