Chronic exposure to hypercortisolism significantly impacts on patients health and health-related quality of life (HRQoL). We developed a disease-generated questio-nnaire to evaluate HRQoL in Cushings syndrome (CS) (CushingQoL); in 125 (104 females) patients recruited in Spain, France, Germany, The Netherlands and Italy, clinical and hormonal data were collected and correlated with results of the generic SF-36 questionnaire, a question on self-perceived general health status and the CushingQoL score. 39 (31%) were currently hypercortisolemic and 47 (38%) adrenal insufficient. Psychometric evaluation was adequate: good feasibility (94%), reliability (Crohnbachs alpha=0.87) and validity (unidimensionality and after Rasch analysis lead to a final version with 12 items). A significant (P<0.001) correlation was observed between CushingQoL score and patients self-perceived general health and SF-36 (Pearsons correlation coefficient >0.597). Patients with hypercortisolism (defined as increased 24-h urinary free cortisol) scored worse (lower) than those without (44+22 vs 56+21, P=0.004). Linear regression analysis identified female gender and hypercortisolism as predictors for worse QoL. Conclusion: CushingQoL is useful to evaluate HRQoL in patients with CS and correlates with clinical parameters. Conducted but not funded by ERCUSYN.
03 - 07 May 2008
European Society of Endocrinology