Adipokines and their influence on blood pressure in young women

M Banerjee; A Vyas; P Pemberton; RA Malik; JK Cruickshank

Introduction: Adiposity has been well known to influence blood pressure. Adipokines are peptides secreted from the adipose tissue. TNF-alpha and IL-6 are pro-inflammatory adipokines while adiponectin and leptin have been known to be influencing vascular function. The influence of adipokines on blood pressure is not yet known. Our hypothesis was that all adipokines positively influenced both systolic and diastolic blood pressure.

Patients and methods: One hundred and ninety-three young women (mean age: 35.3, 95% CI 34.6–36.0 years, mean BMI: 27.3, 95% CI 26.5–28.2 kg/m²) had anthropometry, fasting blood glucose, blood pressure, lipid profile, hs-C reactive protein and adipokines – TNF-alpha, Interleukin-6, adiponectin and leptin measured.

Results: The bivariate correlation between the blood pressure measures and the adipokines were as follows:

	TNF-alpha	IL-6	Adiponectin	Leptin
SBP
r	0.26	0.27	−0.10	0.10
P	<0.001	<0.001	0.17	0.20
DBP
r	0.27	0.31	−0.19	0.29
P	<0.001	<0.001	0.01	<0.001

After adjusting for age, weight, Townsend’s index (measure of social deprivation), ethnicity, smoking history, alcohol consumption, fasting glucose, serum cholesterol, triglycerides and serum C-reactive protein, the independent influence of the adipokines over blood pressure were found to be as follows:

Beta, 95% CI of Beta, P	SBP	DBP
TNF-alpha	0.31, 0.16 to 0.46, P<0.001	0.23, 0.12 to 0.33, P<0.001
IL-6	1.41, 0.7 to 2.1, P<0.001	1.04, 0.56 to 1.52, P<0.001
Adiponectin	0.16, −1.28 to 1.59, P=0.83	−0.07, −1.04 to 0.09, P=0.9
Leptin	−0.27, −0.47 to −0.06, P=0.01	−0.09, −0.23 to 0.06, P=0.23

Conclusion: Adipokines had independent influence over both SBP and DBP. The pro-inflammatory adipokines had more influence on both these measures independent of the individual’s body weight and inflammatory state measured by serum C-reactive protein.

Endocrine Abstracts

P113