Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 20 | ECE2009 | Next issue

11th European Congress of Endocrinology

Basic Highlights

Hot topics: Basic

ea0020htb1 | Hot topics: Basic | ECE2009

Hot topics: Basic

Spyroglou Ariadni , Wagner Sibylle , Manolopoulou Jenny , Hantel Constanze , Reincke Martin , Bidlingmaier Martin , Hrabe de Angelis Martin , Beuschlein Felix

Although primary aldosteronism (PA) is considered to be the most prevalent cause of secondary hypertension the underlying genetic mechanisms have been elucidated only for the rare familial forms of the disease. In an attempt to define novel genetic loci involved in the pathophysiology of PA a phenotype-driven mutagenesis screening after treatment with the alkylating agent N-ethyl-N-nitrosourea was established for the parameter aldosterone. The aldosterone values ...

ea0020htb2 | Hot topics: Basic | ECE2009

Characterization of human adult stem cell populations isolated from subcutaneous and visceral adipose tissue

Baglioni Silvana , Francalanci Michela , Squecco Roberta , Lombardi Adriana , Cantini Giulia , Angeli Roberta , Gelmini Stefania , Guasti Daniele , Benvenuti Susanna , Annunziato Francesco , Bani Daniele , Liotta Francesco , Francini Fabio , Perigli Giuliano , Serio Mario , Luconi Michaela

White adipose tissue acts as an endocrine organ that secretes a variety of adipokines and coordinates a number of biological processes such as energy homeostasis, neuroendocrine and immune functions. Recent studies demonstrated that abundant adipose tissue depots (particularly visceral adipose tissue), by producing inflammatory cytokines, contribute to chronic low-grade inflammation processes which may underlie the pathogenesis of metabolic disorders such as obesity, atheroscl...

ea0020htb3 | Hot topics: Basic | ECE2009

Functional relevance of MC3R and GHSR heterodimerization in hypothalamic weight regulation

Rediger Anne , Tarnow Patrick , Gruters Annette , Schafer Michael , Strotmann Rainer , Schoneberg Torsten , Biebermann Heike

By a systematic approach we investigated the interaction of a selective number of GPCRs that are expressed in the arcuate nucleus and known to play an essential role in hypothalamic weight regulation. Based on the results of a sandwich ELISA and fluorescence resonance energy transfer (FRET) approach we report the interaction of the melanocortin three receptor (MC3R) and the growth hormone secretagogue receptor (GHSR) which are coexpressed on arcuate NPY/AgRP neurons. Fu...

ea0020htb4 | Hot topics: Basic | ECE2009

Mice deficient for the Sam68 RNA binding protein are protected from dietary obesity and insulin resistance

Vogel Gillian , Richard Stephane

The Src substrate associated in mitosis of 68 kDa (Sam68) is a KH-type RNA binding protein that has been shown to regulate several aspects of RNA metabolism. The tyrosine phosphorylation of Sam68 was shown to negatively regulate its RNA binding activity and hence it was termed a Signal Transduction Activator of RNA (STAR) protein. Although KH-type RNA binding domains are known to mediate specific protein-RNA interactions, their RNA targets remain elusive. Nevertheless, Sam68 h...

ea0020htb5 | Hot topics: Basic | ECE2009

Mutations in a novel exon of the LH receptor gene cause male pseudohermaprhoditism

Gromoll Joerg , Kossack Nina , Richter-Unruh Annette , Simoni Manuela

Objectives: Male pseudohermaphroditism, or Leydig cell hypoplasia (LCH), is an autosomal recessive disorder in individuals with a 46, XY karyotype, characterized by a predominantly female phenotype despite the presence of testicular structures. It is caused by mutations in the luteinizing hormone/chorionic gonadotropin receptor gene (LHCGR), which impair either LH/CG binding or signal transduction. However, molecular analysis has revealed that the LHCGR is apparently normal in...