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11th European Congress of Endocrinology

Oral Communications

Thyroid: Basic and Clinical

ea0020oc5.1 | Thyroid: Basic and Clinical | ECE2009

Neurological and behavioral phenotypes in mice lacking Mct8-mediated neuronal T3 uptake

Schweizer Ulrich , Wirth Eva , Roth Stephan , Kohrle Josef , Gruters Annette

Thyroid hormone transport into cells critically depends on plasma membrane transport proteins. One of these, monocarboxylate transporter 8 (MCT8), is mutated in patients suffering from a form of X-linked mental retardation, the Allan-Herndon-Dudley syndrome. These patients are characterized by abnormal thyroid hormone and TSH plasma levels indicating a role for MCT8 in the regulation of the thyroid hormone axis. Mice lacking the Mct8 gene replicate the thyroid hormone a...

ea0020oc5.2 | Thyroid: Basic and Clinical | ECE2009

Selenium and iodine determination from single murine thyroid lobes by TXRF-spectroscopy

Renko Kostja , Behrends Thomas , Stosnach Hagen , Kohrle Josef , Schomburg Lutz

Iodine (I) and selenium (Se) are two essential trace elements for regular thyroid gland functioning and thyroid hormone metabolism. Most Europeans are only marginally supplied with both elements through their daily nutrition. The mammalian organism has developed efficient and highly complex mechanisms to control I and Se uptake, metabolism and recycling. The thyroid gland is equipped with the necessary transporters and metabolizing enzymes for I uptake and bioconversion into t...

ea0020oc5.3 | Thyroid: Basic and Clinical | ECE2009

The role of N-linked oligosaccharides on the function of thyrotropin: development of new agonists and antagonists

Fares Fuad , Azzam Naiel , Bar-Shalom Rinat , Kraiem Zaki

Introduction: Thyrotropin (TSH) and the gonadotropins (FSH, LH, hCG) are a family of heterodimeric glycoprotein hormones composed of two noncovalently linked subunits, α and β. hTSH, heterodimer was converted to a biologically active single-peptide chain, by fusing the common α subunit to the carboxyl-terminal end of hTSHβ subunit in the absence (hTSHβα) or presence of a ~30 aminoacid carboxyl-terminal peptide fr...

ea0020oc5.4 | Thyroid: Basic and Clinical | ECE2009

Selenium supplementation fails to improve thyroid hormone metabolism in subjects with SBP2 gene mutations

Schomburg Lutz , Dumitrescu Alexandra M , Liao Xiao-Hui , Bin-Abbas Bassam , Hoeflich Johanna , Kohrle Josef , Refetoff Samuel

Selenium (Se) is an essential trace element needed for the biosynthesis of selenoproteins. Biosynthesis of such proteins depends on the selenocysteine incorporation sequence binding protein 2 (SBP2), which represents a key trans-acting factor during the translation process. We recently described children with mutations in SBP2 gene who displayed an abnormal thyroid function test(s) and reduced selenoprotein concentrations. Now we aimed to improve selenoprotein biosynthesis and...

ea0020oc5.5 | Thyroid: Basic and Clinical | ECE2009

Graves patients with high sCTLA-4 level are at risk of severe ophthalmopathy

Daroszewski Jacek , Pawlak Edyta , Karabon Lidia , Bolanowski Marek , Jonkisz Anna , Frydecka Irena

Objectives: Graves' disease (GD) is an autoimmune disease caused by combination of environmental and genetic factors. The CTLA-4 gene is a candidate gene for conferring susceptibility to thyroid autoimmunity. Increased serum level of soluble isoform of CTLA-4 molecule (sCTLA-4), resulting by alternative splicing, was found in some autoimmune diseases. The role of this molecule in the pathomechanism of autoimmunity has not been defined.The principa...