Searchable abstracts of presentations at key conferences in endocrinology
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11th European Congress of Endocrinology

Poster Presentations

Growth and Developmental Endocrinology

ea0020p534 | Growth and Developmental Endocrinology | ECE2009

Characterization of growth hormone (GH) mutants R77C and D112G found in patients with retarded growth

Junnila Riia , Braig Friederike , Piilonen Katri , Strasburger Christian , Wu Zida

Introduction: Two heterozygous missense mutations R77C and D112G have been identified in GH-1 gene of patients with short stature by Takahashi et al. These patients had high serum immunoreactive GH concentrations but low IGF-1 concentrations, indicating bioinactivity of their GH. Separation of GH in patients┬ĺ serum by isoelectric focusing revealed the coexistence of mutant and wild type (wt) GH. In order to understand the molecular mechanism of the isolated GH defi...

ea0020p535 | Growth and Developmental Endocrinology | ECE2009

The effect of fetal hypothyroidism on carbohydrate metabolism during adulthood in rats

Farahani Hamid , Asl Saleh Zahedi , Ghasemi Asghar

Introduction: Thyroid hormones have major effects on regulation of metabolism and function of most cells. A number of prevalent diseases during adulthood have been attributed to the intrauterine status during fetal life. In this study, the effect of fetal hypothyroidism on the carbohydrate metabolism during adulthood investigated.Subject and methods: After mating, the pregnant rats were divided in two, the fetal hypothyroidism (FH) and the control (C) gr...

ea0020p536 | Growth and Developmental Endocrinology | ECE2009

Development of specific monoclonal antibodies and highly sensitive immunoassays for 20 kDa and 22 kDa human growth hormone (hGH)

Wu Zida , Devany Emral , Lima Giovanna , Bidlingmaier Martin , Strasburger Charistian

The physiological and pathophysiological significance of hGH isoforms remains to be fully elucidated. In order to study the two most abundant hGH isoforms 20 and 22 kDa hGH, we have generated monoclonal antibodies (mAbs) against 20 and 22 kDa hGH. The mAbs against 20 and 22 kDa were characterized for their specificity and epitopes with different binding assays as well as by Western blot. The mAb 1G12 against 20 kDa with lower than 0.05% cross reactivity to 22 kDa hGH combined ...

ea0020p537 | Growth and Developmental Endocrinology | ECE2009

The effect of gestational hypothyroidism on insulin secretion from isolated islets of adult offspring in male rats

Zahedi-Asl Saleh , Farahani Hamid , Ghasemi Asghar , Faraji Farzaneh , Manaheji Homa

Introduction: Any abnormalities during pregnancy can affect the growth and development of the fetus and may have a long lasting effect presented during adulthood (intrauterine programming). In this study, the effect of maternal hypothyroidism on insulin secretion from the isolated islets of offspring has been investigated in male rats.Materials and methods: In Test group maternal hypothyroidism was induced using 0.02% propylthiouracyl in drinking water t...

ea0020p538 | Growth and Developmental Endocrinology | ECE2009

Short stature in betathalassemia major: a multifactorial condition

Albu Alice , Zirnea Anca , Vladareanu Florentina , Voicu Daniela , Nitu Larisa , Florea Suzana , Fica Simona

Short stature is a frequent finding among patients with beta-thalassemia major, with a major impact on the quality of life and a multifactorial aetiology.Aim: To study the relationship between growth retardation of thalassemic patients and associated sistemic conditions and endocrine complications.Subjects and methods: Cross-sectional study on 59 patients with ╬▓thalassemia major who did not reach their final height, with a mea...

ea0020p539 | Growth and Developmental Endocrinology | ECE2009

Histopathologic changes in pregnant rat pancreas

Ozbek Elvan , Demirci Tuba

Objective: Placental lactogen (PL) produced by the placenta stimulates lipolysis and fatty acid metabolism in the mother. PL is an anti-insulin hormon. It adjusts the metabolic state of the mother during pregnancy to make easy the energy supply of the fetus. It also reduces maternal tissue sensitivity to insulin, leading to gestational diabetes. A moderate hypertriglyceridaemia due to uncontrolled diabetes may be noticeably worsen by the gestation. As a result, acute hypertrig...