Searchable abstracts of presentations at key conferences in endocrinology
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11th European Congress of Endocrinology

Poster Presentations

Signal Transduction

ea0020p678 | Signal Transduction | ECE2009

The MAPKinases ERK1/2 take centre stage in somatotroph physiopathology

Pertuit Morgane , Romano David , Barlier Anne , Enjalbert Alain , Gerard Corinne

Somatotroph pituitary adenomas are characterized by unrestrained hormone secretion and cell proliferation alterations. In those tumors, the only mutation so far unequivocally identified is the gsp oncogene (Gsα protein gain of function mutation). Nethertheless, there is no clear difference in the clinical phenotypes of patients bearing tumor with the gsp oncogene (gsp+) or not (gsp−). In addition, an overexpression of the wild-type Gsα protein has been o...

ea0020p679 | Signal Transduction | ECE2009

Retinol-binding protein 4 activates TGB-β1 expression and apoptosis via phosphorylation of JNK and MAPK in HEK cells

Shin Shyi-Jang , Chen Chao-Hung

Serum retinol-binding protein 4 (RBP4), a new adipocytokine, was reported to increase insulin resistance. RBP4 was significantly elevated in type 2 diabetic patients with microalbuminuria and macroalbuminuria as compared with normoalbuminuric patients. Some adipocytokines have been found to induce cell injury. Therefore, we investigated whether RBP4 could modulate JNK, p38MAPK, ERK and TGF-β1 expression in HEK293 cells by using transfection of p38MAPK and JNK small interf...

ea0020p680 | Signal Transduction | ECE2009

Identification of septin 3 as new protein-protein interaction partner of TrkB

Patrick Tarnow , Heike Gohler , Erich Wanker , Annette Gruters , Heike Biebermann

The melanocortin 4 receptor (MC4R) plays a prominent role in hypothalamic weight regulation. Activation of this receptor results by so far not understood mechanisms in a decrease of food-intake and an increase of energy expenditure. Recently a functional role downstream of MC4R signalling for brain derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase B receptor (TrkB) was reported. TrkB signalling influences several neuronal processes like synapse for...

ea0020p681 | Signal Transduction | ECE2009

A newly identified loss-of-function mutation in helix 5 reveals new insights into signalling mechanisms of the thyrotropin receptor

Winkler Franziska , Kleinau Gunnar , Gruters Annette , Krude Heiko , Krause Gerd , Biebermann Heike

In two siblings suffering from congenital hypothyroidism we identified a homozygous missence mutation Ala579Val in transmembrane helix 5 of the thyrotropin receptor (TSHR) gene which motivated us to investigate molecular details of this mutation.We were interested, firstly, in the functional effects regarding signal transduction and, secondly, in the particular structural properties of the wild type receptor and the Ala579Val mutant. The aim was to gain ...

ea0020p682 | Signal Transduction | ECE2009

Abstract withdrawn....

ea0020p683 | Signal Transduction | ECE2009

Abstract withdrawn....

ea0020p684 | Signal Transduction | ECE2009

Nuclear orphan receptor Nur77 is a mediator of p53-dependent apoptotic response

Sanguinetti Dolores , Carneiro Carmen , Martinez Gloria , Dominguez Fernando , Vidal Anxo

Nur77 is a nuclear orphan receptor belonging to the steroid receptor superfamily. A role for Nur77 has been described in proliferation, differentiation and apoptosis, as a result of its induction in response to multiple signal transduction pathways. Previous studies have suggested that physical interaction between Nur77 and the tumor suppressor p53 can prevent p53 ubiquination and subsequent degradation by hMdm2. This suggests a possible role for Nur77 as a regulator of p53-de...

ea0020p685 | Signal Transduction | ECE2009

On the importance of the selenium status for the inflammatory response

Stoedter Mette , Renko Kostja , Behrends Thomas , Schomburg Lutz

Many endocrine disorders bear an immunological component and involve local cytokines as paracrine signals. Moreover, certain auto-antibodies appear as causative pathological agents in some of the most common endocrine diseases e.g. in type I diabetes mellitus or different forms of autoimmune thyroid disease (AITD). Recently, selenium (Se) status and selenoproteins have emerged as important modifiers of the inflammatory response, AITD or sepsis. Notably, mortality risk of patie...

ea0020p686 | Signal Transduction | ECE2009

Orexins activates protein kinase C-mediated Ca2+ signaling in cultured rat dorsal root ganglion neurons

Ayar Ahmet , Ozcan Mete , Alcin Ergul , Serhatlioglu Ihsan , Kelestimur Haluk

Orexins, the novel pluripotent hypothalamic peptides, have been shown to exert important roles in the regulation of multiple physiological functions and behaviors including appetite, sleep and wakefulness and energy homeostasis through neural and endocrine mechanisms. Evidence emerging from recent research indicates that orexins may be involved in many other physiological functions. Our previous results have suggested that orexin-A and B activate Ca2+ signaling in c...

ea0020p687 | Signal Transduction | ECE2009

High susceptibility haplotypes of the TSHR gene in Graves-Basedow disease

Lucas Anna , Colobran Roger , Armengol Maria Pilar , Ruiz Marta , Martinez Eva , Juan Manel , Pujol-Borrell Ricardo

The mechanisms triggering autoimmunity in the Graves-Basedow disease (GBD) are unknown, although the evidence for a genetic predisposition is well established. The thyrotropin receptor (TSHR) is a good candidate gene.Objectives: To identify the main alleles/haplotypes of the TSHR gene, and to analyze the existence of TSHR susceptibility alleles to the GBD.Material and methods: To establish the main alleles of TSHR gene, 54 polymorp...

ea0020p688 | Signal Transduction | ECE2009

The effect of circulating estradiol concentrations on gonadotropin secretion in young and old castrated men

S. ten Kulve Jennifer , H. de Jong Frank , de Ronde Willem

Context: In men, a decline of mean circulating testosterone level is seen with increasing age. This decline is associated with an increase in the mean levels of LH and FSH, albeit insufficient to maintain testosterone at its original level. It has been speculated that a higher sensitivity of the hypothalamus and/or pituitary for the feedback effect of circulating testosterone in older men is responsible.Objective: To compare the effect of experimentally ...