Neuroendocrine tumors

Neuroendocrine tumors (NETs) constitute a rather heterogenous group of malignancies that are considered to be rare. However, resent data is indicating a significant increase in both incidence and prevalence over the last decades, with an overall incidence of 5/100 000/year and prevalence of 25/100 000/year.The treatment of NETs is based on the tumor biology (proliferation capacity and differentiation), tumor localisation and spread (TNM-staging). Surgery...

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ea0020s16.2 | Neuroendocrine tumors | ECE2009

Moleculargenetics of neuroendocrine tumours

Neumann Hartmut

Neuroendocrine tumor (ENET) is a distinct term and includes specific selected tumors of the foregut, midgut and hindgut. The term separates other neurocrest-derived tumors likewise pheochromocytomas, paragangliomas as well as medullary thyroid carcinoma and parathyroid adenoma. There are sporadic and hereditary ENETs. The prominent hereditary group of ENETs forms the syndrome of multiple endocrine neoplasia type 1 (MEN1). Other ENETS are regarded as sporadic.<p class="abst...

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ea0020s16.3 | Neuroendocrine tumors | ECE2009