Searchable abstracts of presentations at key conferences in endocrinology
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11th European Congress of Endocrinology


Pituitary cell biology

ea0020s8.1 | Pituitary cell biology | ECE2009

Imaging pituitary cell networks and function

Mollard Patrice

The pituitary gland generates highly ordered hormone pulses to control basic body functions such as growth, fertility, and lactation. Using an approach combining transgenic mice models with cell-specific fluorescent tags (GH-GFP, PRL-DsRed, POMC-GFP, LH-Cerulean…) and functional optical imaging (pituitary-scale 2-photon excitation microscopy, cellular in vivo imaging), we recently unveiled that most, if not all pituitary cell types are much more organized than we ...

ea0020s8.2 | Pituitary cell biology | ECE2009

New regulatory mechanisms controlling pituitary hormone secretion

Gracia-Navarro Francisco

Hormone release by pituitary cell types is primarily regulated by stimulatory and inhibitory factors secreted by the hypothalamus. In turn, factors produced by the target organs controlled by the pituitary exert a feedback regulation on the corresponding pituitary cells. However, recent data indicate that, besides these factors, other mechanisms operate to finely tune pituitary function. These include both novel peripheral regulatory factors as well as intrinsic cellular eleme...

ea0020s8.3 | Pituitary cell biology | ECE2009

New regulators of pituitary cell proliferation

Korbonits Marta

Sporadic and familial pituitary adenomas are being recognised and diagnosed with increasing frequency due to better diagnostic techniques and improving awareness.Recently, a number of important steps have been taken to clarify the molecular pathological events leading to familial pituitary tumorigenesis, with the recognition of the tumour suppressor genes p27 and AIP as causes of familial pituitary tumours in addition to previously-establis...

ea0020s8.4 | Pituitary cell biology | ECE2009

Dual function of dopamine/somatostatin hybrid agonists

Saveanu Alexandru , Brue Thierry , Enjalber Alain , Jaquet Philippe , Barlier Anne

Somatostatin acts as an inhibitor of hormonal secretion and cell proliferation by acting through 5 somatostatin receptors subtypes (sst1–5). Coupling with Gi/o proteins is associated with effects on various transduction pathways, as adenylate cyclase inhibition or phosphatases activation. Dopamine receptor subtype 2 (D2DR) acts through coupling with similar G-proteins and transduction pathways. Sst, mostly sst2 and sst5, are coexpressed with D2DR in many neuroendocrine no...