Endocrine Abstracts (2009) 20 P102

Levothyroxine suppression treatment for benign thyroid nodules alters coagulation

Tevfik Demir, Baris Akinci, Abdurrahman Comlekci, Oguzhan Karaoglu, Mehmet Ali Ozcan, Serkan Yener, Faize Yuksel, Mustafa Secil & Sena Yesil


Dokuz Eylul University, Izmir, Turkey.


Objective: Endogenous hyperthyroidism is associated with altered coagulation. The aim of the present study is to investigate the effect of levothyroxine (LT4) suppression treatment for benign thyroid nodules on coagulation system.

Design: Prospective case-control study.

Patients: Thirty consecutive euthyroid pre-menopausal women with nodular goitre disease and 28 healthy controls were included in the study.

Measurements: Plasma fibrinogen, d-dimer, von Willebrand factor (vWF), tissue factor (TF), tissue plasminogen activator (tPA), plasminogen activator inhibitor (PAI-1) and tissue factor pathway inhibitor (TFPI) levels were measured at baseline and after LT4 suppression therapy.

Results: Plasma levels of fibrinogen, d-dimer, vWF, TF and PAI-1 increased significantly after treatment with LT4 for one year. Serum FT4 was a significant predictor of increased fibrinogen, vWF and PAI-1 levels, when the data was controlled for age and BMI.

Conclusions: Our results suggest that LT4 suppression therapy for benign thyroid nodules is associated with enhanced coagulation.

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