Endocrine Abstracts (2009) 20 P114

Analysis of demographic and clinical factors, affecting the outcome of radioiodine therapy in patients with hyperthyroidism

Malgorzata Kanpska-Kucharska1, Lidia Oszukowska1, Malgorzata Karbownik-Lewinska2,4 & Andrzej Lewinski3,4

1Department of Nuclear Medicine and Oncological Endocrinology, Medical University, Lodz, Poland; 2Department of Oncological Endocrinology, Medical University, Lodz, Poland; 3Department of Endocrinology and Metabolic Diseases, Medical University, Lodz, Poland; 4Polish Mother’s Memorial Hospital – Research Institute, Lodz, Poland.

Introduction: The influence of demographic and clinical factors on the outcome of 131I therapy in hyperthyroid patients has been examined, based on a retrospective evaluation of results obtained in patients, submitted to 131I treatment. The goal of the study was an analysis of factors, including the age and sex of patients, disease duration time, as well the hormonal status before 131I application, which could have influenced the effects of therapy with radioiodine 131I.

Patients, materials and methods: The study involved five hundred (500) randomly selected patients with hyperthyroidism, treated with 131I radioiodine. The following three (3) groups were defined: Group 1 – patients with multinodular goitre – n=200; Group 2 – patients with a single autonomous nodule of the thyroid – n=100; Group 3 – patients with Graves’ disease – n=200. The local ethics committee approved the study.

Results and conclusions: The obtained results indicate that the efficacy of therapy with 131I, applied in patients with multinodular goitre, single thyroid nodule and Graves’ disease, does not depend on either patient sex or patient age. The length of antithyroid treatment before 131I therapy onset does not appear to have any effect on the therapy outcome, while the baseline TSH concentration seems to be significant only in case of Graves’ disease.

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