Aim: The aim of the study was the evaluation of the relationship between thyroid size and the result of radioactive iodine therapy in patients treated due to Graves hyperthyroidism.
Material and methods: The study group included 150 subjects (127 M and 23 F), aged from 20 to 78 years (mean 48.33 years) at the moment of 131I therapy.
In all patients the thyroid technetium-99m scan and determination of the serum levels of fT
After one year follow-up, the thyroid function has been estimated.
Successful therapy was defined as euthyroidism or permanent hypothyroidism.
Results: The thyroid weight in the group of patients before treatment ranged from 54 to 367 g (mean 72.34±47.24 g). After one year, euthyrosis was observed in 47 patients (31.35%), hypothyroidism in 47 parsons (31.35%). In 56 subjects (37.3%) persistent hyperthyroidism have been diagnosed. Among patients with successful therapy, the thyroid mass ranged between 5.4 and 367 g (mean 61.97±45.5 g), but in ineffective therapy group ranged between 8.2 and 196.0 g (89.59±45.36 g).
The difference of thyroid mass was statistically significant (P=0.0004).
Conclusions: The obtained results confirm, that 131I therapy is effective method of hyperthyroidism treatment, but patients of the ineffective therapy group presented larger goiter.
25 - 29 Apr 2009
European Society of Endocrinology