Endocrine Abstracts (2009) 20 P342

Relationship between lipid oxidation and insulin resistance in type 2 diabetes mellitus

Mitra Niafar1,2, Manouchehr Nakhjavani1,2, Alireza Esteghamati1,2 & Mehrshad Abasi1,2

1Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran; 2Tehran University of Medical sciences, Tehran, Islamic Republic of Iran.

The endothelial dysfunction and atherosclerosis. Recent studies have demonstrated that the amount of oxidized LDL (Ox-LDL) in plasma is correlated with IR in non-diabetic population. The intent of this study was to evaluate correlation of Ox-LDL and IR in diabetic patients, and to compare it with normal individuals.

Methods: A total of 150 individuals aged 40 to 65 years were studied including 81 type 2 diabetic patients and 69 non-diabetic sex and BMI matched healthy persons. Demographic characteristics and anthropometric data of participants were recorded. Levels of circulating Ox-LDL were measured with 2 monoclonal antibody-based competitions ELISA. Oxidized LDL antibodies (OLAB), glucose, insulin, and HbA1C were also determined in fasting blood samples. Insulin resistance was estimated according to homeostasis model assessment of insulin resistance (HOMA-IR).

Results: After considering all the relevant factors including age, duration of diabetes, BMI, systolic and diastolic blood pressure, serum lipids, and HOMA-IR, regression analysis demonstrated that there was a significant correlation of Ox-LDL with cholesterol and HOMA-IR in all participants (r=0.39, P<0.005). This was also true for diabetic patients but in non-diabetic group Ox-LDL was only correlated with cholesterol. OLAB had weak but significant correlation with BMI in both diabetic and non diabetic groups(r=0.23 and 0.24 respectively, P<0.05).

Conclusion: Our results suggest an association between insulin resistance and increased LDL oxidation independent of the effect of other contributing factors.

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