Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 20 | ECE2009 | Next issue

11th European Congress of Endocrinology

Poster Presentations

Diabetes and Cardiovascular

ea0020p333 | Diabetes and Cardiovascular | ECE2009

Characterization of a young population of type 1 diabetics

Vieira Alexandra , Fagulha Ana , Barros Luisa , Figueiredo Julia , Santos Jacinta , Martinho Mariana , Carrilho Francisco , Carvalheiro Manuela

Introduction: Type 1 diabetes is one the most common chronic diseases found in children and youngsters.Objectives: Characterization of a sample of young type 1 diabetic patients, treated with multiple daily injections of insulin.Patients and methods: Analysis of patients files with ages between 11 and 26 years observed on diabetology consultation during the first semester of 2008, with diagnosis of diabetes for at least 6 months. P...

ea0020p334 | Diabetes and Cardiovascular | ECE2009

How diabetic children’s families inject them insulin at home

Kouhnavard Marjan , Kohankary Mahin , Razavi Alavieh

Background: Diabetes mellitus type one is a common metabolic disorder among pediatrics. Diabetic children’s families should be able to measure the blood sugar of their children and inject them insulin correctly.Materials & methods: Thirty-six families which had diabetic children were recruited to this study and were asked about the way they were injecting insulin to their children.Results: Forty-eight percent of the client...

ea0020p335 | Diabetes and Cardiovascular | ECE2009

HLA DQB1 and HLA DQA1 genotypes prevalence in children and adolescence with new-onset diabetes type 1 in the lower Silesia region

Zak Teresa , Malodobra Malgorzata , Zubkiewicz Agnieszka , Noczynska Anna

The first degree relatives of patients with diabetes type 1 have increased genetic risk of developing clinical disease. In the population of Polish diabetic subjects the most frequent alleles are HLA- DRB1*04, DRB1*03, DQA1 and DQB1. The ‘high-risk genotype’ may differ among populations.The aim of this paper was to analyze prevalence of genetic risk factors in patients with new-onset diabetes in Lower Silesia and to compare the data with Polish...

ea0020p336 | Diabetes and Cardiovascular | ECE2009

Comparative molecular analysis of TRAIL ligand and receptor expression profiles in cyclophosphamide versus streptozotocin-induced diabetes in non-obese diabetic (NOD) mice

Kahraman Sevim , Dirice Ercument , Elpek Ozlem , Balci Mustafa Kemal , Omer Abdulkadir , Sanlioglu Salih , Sanlioglu Ahter

Background: NOD mice are the most frequently preferred animal models in type 1 diabetes (T1D) research. They develop spontaneous disease in 24 to 30 months. T1D can also chemically be induced in NOD mice for a faster disease progression. Two commonly used diabetes-inducing agents are Streptozotocin (STZ), which destructs pancreatic beta cells mainly through DNA fragmentation, and Cyclophosphamide (CY), which acts on suppressor T cells. TNF-Related Apoptosis-Inducing Ligand (TR...

ea0020p337 | Diabetes and Cardiovascular | ECE2009

Association of IL-4 promoter polymorphisms in Taiwanese patients with type 2 diabetes mellitus

Shiau Ming-Yuh , Huang Chien-Ning , Ho Kuo-Ting , Chang Yih-Hsin

Type 2 diabetes mellitus (T2DM) is a common endocrine disease. Many factors can lead to the onset of T2DM, however, host genetic factors and environmental factors are the focus of discussion. The aim of this study is to investigate the putative correlation between the promoter polymorphisms of interleukin-4 (IL-4), one of the immune-regulatory type 2 helper T cell cytokines, and T2DM. Genomic DNA from 425 Taiwanese T2DM patients and 148 non-diabetic control study subjects were...

ea0020p338 | Diabetes and Cardiovascular | ECE2009

Saxagliptin added to a thiazolidinedione, metformin or a sulphonylurea improves glycaemic control in patients with inadequately controlled type 2 diabetes mellitus

Maheux Pierre , Allen Elsie , Ravichandran Shoba , List James , Chen Roland

Saxagliptin (SAXA) is a potent, selective dipeptidyl peptidase-4 (DPP-4) inhibitor, specifically designed for extended inhibition of the DPP-4 enzyme. The efficacy and safety of SAXA 5 mg add-on therapy to a thiazolidinedione (TZD), metformin (MET), or an intermediate dose of glibenclamide (GLY), was investigated in patients with inadequately controlled (HbA1c>7.0%) type 2 diabetes mellitus (T2DM) in three randomised, double-blind trials (CV181-013, CV181-014 an...

ea0020p339 | Diabetes and Cardiovascular | ECE2009

Change of physical activity, diet habits and risk of diabetes after lifestyle intervention. Diabetes in Europe: prevention using lifestyle, physical activity, and nutritional intervention: the DePlan Project Krakow

Gilis-Januszewska Aleksandra , Hubalewska-Dydejczyk Alicja , Piwonska-Solska Beata , Szybinski Zbigniew , Linstrom Jaana , Peltonen Marku , Schwarz Peter , Barengo Noel , Tuomilehto Jaakko

Aim: Aim of the study was to assess the effectiveness of the structured lifestyle intervention in diabetes type 2 high risk people.Methods: The De-Plan Project participants were selected based on FINDRISK over 14. Exclusion criteria were known or OGTT diabetes. Intervention completed by 175 participants consisted of 10 group sessions on lifestyle changes, diet and physical activity education, and 6 telephone motivation sessions and voluntary physical act...

ea0020p340 | Diabetes and Cardiovascular | ECE2009

Limits in using brain natriuretic peptide (BNP) as a biomarker of acute right ventricular dysfunction in pulmonary embolism

Pascu Alina Mihaela , Radoi Mariana , Coculescu Mihail

Background: Risk stratification could be lifesaving in acute pulmonary embolism (PE). Echocardiographic (ECHO) acute right ventricular dysfunction (RVD) is the actual ‘gold standard’ in risk assessment of patients with PE. We previously demonstrated that plasma BNP levels were significantly higher in patients with PE and acute RVD on ECHO versus patients with normal right ventricular (RV) function on ECHO.Aim and objective: Evaluation of the li...

ea0020p341 | Diabetes and Cardiovascular | ECE2009

Determination of oxidized LDL and anti oxidized LDL antibody in patients with type 2 diabetes

Niafar Mitra , Nakhjavani Manouchehr , Esteghamati Alireza

Background: Oxidized low-density lipoprotein (Ox-LDL) is a key factor in the development of arteriosclerosis. It can cause endothelial dysfunction and augment lipid accumulation within the arterial wall. Increased oxidative stress in diabetes contributes to this process. Ox-LDL is a highly immunogenic molecule and it is not clear whether oxidized LDL antibodies (OLAB) are pathogenic or protective in arteriosclerosis? The aim of this study was to evaluate Ox-LDL and its antibod...

ea0020p342 | Diabetes and Cardiovascular | ECE2009

Relationship between lipid oxidation and insulin resistance in type 2 diabetes mellitus

Niafar Mitra , Nakhjavani Manouchehr , Esteghamati Alireza , Abasi Mehrshad

The endothelial dysfunction and atherosclerosis. Recent studies have demonstrated that the amount of oxidized LDL (Ox-LDL) in plasma is correlated with IR in non-diabetic population. The intent of this study was to evaluate correlation of Ox-LDL and IR in diabetic patients, and to compare it with normal individuals.Methods: A total of 150 individuals aged 40 to 65 years were studied including 81 type 2 diabetic patients and 69 non-diabetic sex and BMI ma...

ea0020p343 | Diabetes and Cardiovascular | ECE2009

Role of soluble fas/fas ligand pathway and osteoprotegerin levels in patients with diabetic foot

Guldiken Sibel , Taskiran Bengur , Demir Muzaffer , Tugrul Armagan , Altun Betul Ugur

Aim: Diabetic foot is a devastating complication of diabetes mellitus. Many factors such as neuropathy, vascular injury and infection contribute in the development of diabetic foot. Programmed cell death is a pathway that causes a tendency for the development of atherosclerosis. Whereas Fas/Fas ligand pathway induces apoptosis, osteoprotegerin (OPG) causes calcification in vascular area and also effects apoptotic pathway. In the present study, we aimed to investigate the role ...

ea0020p344 | Diabetes and Cardiovascular | ECE2009

: Abstract withdrawn....

ea0020p345 | Diabetes and Cardiovascular | ECE2009

Evaluation of coronary artery disorders in diabetic patients with no or atypical cardiac symptoms

Zakavi Rasoul , Rokni Haleh , Mousavi Zohreh , Taherpour Mahdi , Rajabian Reza , Dalooei Mohamad Khajeh

Introduction: Coronary artery disorder has been featured as the leading cause of dead in diabetics. This study was designed to assess the prevalence of silent myocardial ischemia in asymptomatic patients with diabetes.Methods and patients: One hundred and thirty asymptomatic type 2 diabetic patients were enrolled in the study. A questioner was filled including patients’ demographic information and routin laboratory tests. HsCRP was measured for all ...

ea0020p346 | Diabetes and Cardiovascular | ECE2009

Impaired glucose regulation and arterial stiffness

Shargorodsky Marina

Background: Glucose intolerance produces structural and functional changes in the arterial wall which contribute to the excess cardiovascular morbidity and mortality. The present study investigated association between glucose tolerance status and arterial stiffness in subjects with normal and impaired glucose regulation (IGR).Methods: The study group consisted of 283 Caucasian subjects, including 111 subjects with normal glucose tolerance (NGT), 61 subje...

ea0020p347 | Diabetes and Cardiovascular | ECE2009

Association between polymorphisms in the promoter of heme oxygenase-1 and vascular complications in type 2 diabetic patients

Lee Yong-Ho , Kang Eun Seok , Ahn Chul Woo , Cha Bong Soo , Lee Hyun Chul

Heme oxygenase-1 (HO-1) catalyzes the conversion of heme to carbon monoxide, free iron, and biliverdin, which is then changed into bilirubin. These substances have been recently demonstrated to have antiatherogenic and antioxidative properties. The GT-repeat polymorphism is reported to be an independent risk factor for restenosis after coronary stenting and T (−413). A polymorphism increased the activity of HO-1 promoter, leading to reduce the incidence of ischemic heart...

ea0020p348 | Diabetes and Cardiovascular | ECE2009

Paradoxical effects of GABA on glucose-stimulated insulin secretion from isolated islets in rat

Shahrivar Farzaneh Faraji , Ghasemi Asghar , Motamedi Fereshteh , Asl Saleh Zahedi

Introduction: The islets of pancreas contain relatively high levels of Gamma-amino butyric acid (GABA). This study was designed to determine the role of the GABA and GABAB receptor on glucose-stimulated insulin secretion of isolated islets in rats.Materials and methods: The Collagenase digestion technique was used to isolate the islets from male Wistar rats and insulin secretion was assessed in islets exposed to glucose (8.3, 16.7 mM) in prese...

ea0020p349 | Diabetes and Cardiovascular | ECE2009

Inspiratory muscle strength is correlated with carnitine levels in type 2 diabetes

Kilicli Fatih , Dokmetas Hatice Sebila , Candan Ferhan , Ozsahin Sefa Levent , Korkmaz Serdal , Amasyali Elvan , Fakioglu Koray , Acibucu Fettah , Dal Kursat

Background: Plasma carnitine insufficiency has been caused muscle weakness. Carnitine levels and pulmonary functions were lower in patients with diabetes.Objective: To determine whether pulmonary functions are correlated with carnitine levels in patients with type 2 diabetes.Setting: Internal medicine outpatient clinic of a university hospital.Methods: Forty-nine patients with type 2 diabetes and 34 healthy c...

ea0020p350 | Diabetes and Cardiovascular | ECE2009

Mildronate positively affects compensation of diabetes in streptozotocin rats and alters iNOS gene expression in rat tissues

Sokolovska Jelizaveta , Kalvinsh Ivars , Sharipova Jelena , Lauberte Lasma , Sjakste Nikolajs

Mildronate, a γ-butyrobetaine analogue is actually used as an antiischemic drug. It was also shown to have effect on mechanisms of glucose utilization.Methods: Diabetes mellitus in Wistar rats was induced by injection of streptozotocin (50 mg/kg). Experimental rats were treatment with Mildronate (100 mg/kg daily, per os) for 6 weeks. Weight, blood glucose concentration, blood triglyceride concentration, blood ketone body concentration, glycat...

ea0020p351 | Diabetes and Cardiovascular | ECE2009

Topical Atorvastatine may be beneficial in the treatment of the wounds in diabetic rats

Gulcan Erim , Cayci Kasim , Toker Serdar , Olgun Esra G , Ozay Yusuf

Background: Currently, it is reported that statins may be useful in the treatment of DM foot ulceration1. The aim of the study was to evaluate treatment with topical atorvastatin of the wounds of streptozotocine induced diabetic rats.Materials and methods: Fifteen×fifteen mm sized wound were created in streptozotocin-induced rats. A total of twenty-eight diabetic rats were studied in 4 groups (n: 28). Any treatment was not administ...

ea0020p352 | Diabetes and Cardiovascular | ECE2009

Coronary heart disease risk reduction in obese patients submitted to adjustable gastric band

Duarte Leone , Silva-Nunes Jose , Lopes Ana-Filipa , Santos Cristina , Coutinho Jose-Mario , Botelho Maria-Manuel , Albuquerque Antonio , Malheiro Fernando

Background: Obesity is related to an increased cardiovascular risk, namely coronary heart disease risk (CHDr). Type 2 diabetes (T2D) is frequently associated with obesity and, by itself, is an important CHDr factor. Interventions that induce weight loss would be expected to attenuate CHDr in obese patients.Aims: To evaluate variation in cardiovascular risk profile one year after adjustable gastric banding (AGB), in obese patients (with and without T2D); ...

ea0020p353 | Diabetes and Cardiovascular | ECE2009

Atherogenic and anti-atherogenic risk markers in subjects with obesity and/or type 2 diabetes

Rosso Denise , Bender Valeria , Furtado Valeria

Introduction: A subclinical inflammatory state in obesity may be the link between diabetes mellitus (DM) and atherogenesis. This study aimed to investigate the relationship between pro atherogenic factors (C reactive protein (CRP), interleukine 6 (IL-6), vascular adhesion molecular type 1 (VCAM-1)), and anti-atherogenic factor adiponectin in subjects with obesity and DM.Methods: One hundred and twelve subjects (51 men, 103 women) were enrolled: group DM ...

ea0020p354 | Diabetes and Cardiovascular | ECE2009

Optimal fasting plasma glucose level for diagnosis of diabetes in a Singaporean population

Khoo Joan

Aim: Diabetes mellitus is defined by the World Health Organization (WHO) as fasting plasma glucose (FPG) ≥7.0 mmol/l (mM) or 2-hour post-load glucose (2HPG) ≥11.1 mM in the 75-gram oral glucose tolerance test (OGTT). However, reported FPG cut-off levels that correspond to this 2HPG level are below 7.0 mM in Asian studies. Our study thus aims to find the optimal FPG cut-off that corresponds to 2HPG of 11.1 mM in an Asian population in Singapore.<p class="abstext...

ea0020p355 | Diabetes and Cardiovascular | ECE2009

Endogenous estrogen levels are associated with endothelial function in males independently of lipid levels

Saltiki Katerina , Stamatelopoulos Kimon , Voidonikola Paraskevi , Mantzou Emily , Papamichael Christos , Alevizaki Maria

Introduction-aim: It has been suggested that estrogen may play an important role in the regulation of endothelium-dependent vasodilatation in both sexes. Especially in men, estradiol administration has been shown to improve endothelial function; however such reports are conflicting. The aim of our study was to examine the relation of endogenous sex hormone levels with markers of early atherosclerosis in a cohort of apparently healthy individuals.Methods:...

ea0020p356 | Diabetes and Cardiovascular | ECE2009

Glucose intolerance and risk of cardiovascular disease: results of the 7.6 year follow-up of the Tehran lipid and glucose study (TLGS)

Hadaegh Farzad , Khalili Davood , Fahimfar Nooshin , Tohidi Maryam , Sheikholeslami Farhad , Azizi Fereidoun

Background: To determine the risk of cardiovascular disease (CVD) in an Iranian population according to glucose tolerance status.Methods and results: The study population consisted of 1752 men and 2273 women aged ≥40 years without CVD. After a median follow up of 7.6 years, 340 CVD events occurred (197 in men and 143 in women). Women generally had more Framingham risk score (FRS) than men (12.7 vs 11.9, P<0.001) and there was no differen...

ea0020p357 | Diabetes and Cardiovascular | ECE2009

Pharmacokinetics of the dipeptidyl peptidase-4 inhibitor saxagliptin in subjects with renal impairment

Boulton David , Tang Angela , Patel Chirag , Li Li , Xu Xiaohui , Frevert Ernst , Kornhauser David

Background/aims: Saxagliptin is a potent, selective dipeptidyl peptidase-4 (DPP-4) inhibitor, specifically designed for extended inhibition of the DPP-4 enzyme. Saxagliptin is cleared by both metabolism and renal excretion. The aims of this study were to determine the effect of renal impairment (RI) and haemodialysis (HD) on the pharmacokinetics of saxagliptin.Methods: This open-label, parallel-group study was conducted in subjects with normal renal func...

ea0020p358 | Diabetes and Cardiovascular | ECE2009

Biphasic insulin aspart 30/70 improves glycaemic control in patients with type 2 diabetes: clinical practice experience from Indian subgroup of the IMPROVE study™

Unnikrishnan AG , Shah Siddharth , Asirvatham Arthur , Chakkarwar Praful , Moharana Ashok , Kapoor Dheeraj

Aims & objectives: IMPROVE™ is a 6-month, multi-national, prospective, observational study, assessing the safety and efficacy of biphasic insulin aspart 30/70 (BiAsp 30) in patients with type 2 diabetes.Methods: We present the efficacy data from the Indian cohort of IMPROVE study. A total of 17 995 subjects entered the study and 16 942 subjects completed the study. BiAsp 30 was initiated and dose was adjusted at the physician’s discretion, ...

ea0020p359 | Diabetes and Cardiovascular | ECE2009

Saxagliptin either as add-on therapy to metformin or as initial combination therapy with metformin improves glycaemic control in patients with type 2 diabetes

Pfutzner Andreas , Gurieva Irina , Antsiferov Mikhail , Allen Elsie , Ravichandran Shoba , Chen Roland

The efficacy and safety of saxagliptin – a potent, selective dipeptidyl peptidase-4 (DPP-4) inhibitor, specifically designed for extended inhibition of the DPP-4 enzyme – was investigated in two double-blind, randomised trials (CV181-014/Study 1 and CV181-039/Study 2), either as add-on therapy in patients with type 2 diabetes mellitus (T2DM) inadequately controlled by metformin alone (HbA1c 7.0–10.0%) or as initial combination therapy with metformin i...

ea0020p360 | Diabetes and Cardiovascular | ECE2009

Effects of estrogen therapy on cardiovascular risk factor in transsexuals

Bochetti Mara , Casalino Laura , Agosti Sergio , Teti Claudia , Minuto Francesco M , Ferone Diego

Estrogens play a protective role on the peripheral vascular endothelium in both females and males, however, no studies have reported on the effects of estrogens on male coronary arterial reactivity. We investigated the effects of estrogen therapy on coronary and endothelial function in a group of male to female transsexuals (M-to-F).Eight M-to-F transsexuals (group A), receiving oral estrogen therapy for 72 months were studied in comparison with 23 age-m...

ea0020p361 | Diabetes and Cardiovascular | ECE2009

Carotid intima media thickness and serum osteoprotegerin and RANKL levels in diabetic and prediabetic patients

Isildak Serife Mehlika , Barak Anil , Yesilkaya Yakup , Akata Deniz , Gurlek Omer Alper

While well defined for their roles in new bone formation, osteoprotegerin and RANK-ligand (RANKL) are also being questioned for their possible association with the atherosclerotic process since the similarity between the pathogenic process of atherosclerotic plaque calcification and new bone formation is recently under observation. In our study we aimed to find whether there is an association between OPG and RANKL levels and carotid intima media thickness (taken as a measure o...

ea0020p362 | Diabetes and Cardiovascular | ECE2009

Klotho gene polymorphism may be a genetic risk factor for metabolic syndrome in men

Katsoulis Constantinos , Chatzikyriakidou Anthi , Xita Nektaria , Georgiou Ioannis , Tsatsoulis Agathocles

Introduction: Klotho has an important role in insulin signaling and the development of ageing-like phenotypes in mice. Recently, the G-395A polymorphism in the promoter region of the human klotho gene has been reported to affect promoter function. It has been also shown to be an independent genetic risk factor for atherosclerotic cardiovascular disease. The aim of this study was to examine the possible role of this polymorphism in the metabolic syndrome....

ea0020p363 | Diabetes and Cardiovascular | ECE2009

Chemotherapy does not influence measures of glycaemic control in non-diabetic patients affected by acute leukaemia

Triggiani Vincenzo , Guastamacchia Edoardo , Liso Vincenzo , Specchia Giorgina , Resta Francesco , Sabba Carlo , Licchelli Brunella , Tafaro Emilio

Aim: Aim of the study was the evaluation of the effects of chemotherapy on insulin secretion and insulin sensitivity in patients affected by acute leukaemia.Materials and methods: Thirty-two non-diabetic patients (17 male, 15 female; age 51.1±17.4, range 16–76 years; BMI=25.1±3.7, range 18.4–32.8 kg/m2; 6=18% with a family history of diabetes mellitus) affected by acute leukaemia, 4 LLA (12.5%) and 28 LMA (87.5%), have been...

ea0020p364 | Diabetes and Cardiovascular | ECE2009

Pancreatic function in β-thalassemic patients

Vryonidou-Bompota Andromachi , Loi Vasiliki , Vasiliou Georgia , Terzi Thomais , Karagianni Olympia , Tzioras Costas , Phenekos Costas

Background & aims: Impaired glucose tolerance and diabetes as well as cardiac dysfunction are known complications in homozygous beta-thalassemic transfused patients due to iron overload. We aimed to study pancreatic alpha and beta-cell function in regularly transfused patients with homozygous beta-thalassemia and to investigate if cardiac dysfunction may correlate with the development of impaired glucose metabolism.Methods: An oral glucose tolerance ...

ea0020p365 | Diabetes and Cardiovascular | ECE2009

Characterization of type I interferon (IFN) mediated diabetes sparing activity

Sobel Douglas , Ahvazi Behrouz , Pontzer Carol

We have shown that Type I IFN paradoxically inhibits autoimmune diabetes in the NOD mouse and BB rat. We assessed the structure function relationship and potential mechanism of this interferon action by determining: (1) the diabetes sparing effect of several type 1 IFNs: recombinant human IFN-A/D bgl 11 (rIFN-alpha), rIFN-alphaB/D, rIFN-alpha-consensus (CIFN), IFN-taumod1 in NOD mice (2) the effect of IFN-tau administration in IL-4 KO and IFN-gamma KO NOD mice (3) the effect o...

ea0020p366 | Diabetes and Cardiovascular | ECE2009

A comparison between adhesion molecules (as markers of inflammation) in identifying cardiovascular disease in postmenopausal women

Sitar-Taut Adela-Viviana , Cebanu Mirela , Soritau Olga , Stugren Carmen , Pop Dana , Zdrenghea Dumitru Tudor

Background: There are increasing evidences that inflammation is involved in the pathophysiology of both coronary heart disease and cerebrovascular disease. Adhesion molecules have been advocated as a marker of inflammation.Objectives: To evaluate the capacity of inflammation’s markers (sICAM1, sVCAM1) to identify cardiovascular disease, comparing adhesion molecules with a standard diagnosis of cardiovascular disease.Methods: W...

ea0020p367 | Diabetes and Cardiovascular | ECE2009

The relationship between hemoglobin levels and endothelial functions in diabetes mellitus

Sonmez Alper , Yilmaz M Ilker , Zoccali Carmine , Saglam Mutlu , Kilic Selim , Uckaya Gokhan , Eyileten Tayfun , Yenicesu Mujdat , Kutlu Mustafa

Introduction: Hemoglobin (Hb) is the main carrier and buffer of Nitric oxide. Recently, an inverse association between Hb and the endothelium dependent relaxation was observed in patients with Type 2 diabetes. Testing whether this association exists also in diabetic nephropathy is important because anemia in these patients starts at an earlier stage than in other renal disease. Also, at population level diabetes and renal dysfunction, particularly albuminuria, contribute indep...

ea0020p368 | Diabetes and Cardiovascular | ECE2009

Lack of association between polymorphisms at the adiponectin gene locus and type 2 diabetes as well as body mass index in Latvian population

Klovins Janis , Kalnina Ineta , Mackevics Vitolds , Fridmanis Davids , Nikitina-Zake Liene , Pirags Valdis

Association studies between genetic variants of adiponectin gene and susceptibility to type 2 diabetes (T2D) and increased body mass index (BMI) have provided contradictory results. We selected 10 SNPs (rs2241767, rs1501299, rs3777261, rs16861210, rs2241766, rs822396, rs182052, rs17300539, rs16861194, rs266729) in promoter and coding regions of adiponectin gene based on haploblock structure and previously reported association studies. Selected SNPs were screened in 170 patient...

ea0020p369 | Diabetes and Cardiovascular | ECE2009

Epicardial adipose tissue thickness and serum visfatin levels in patients with new diagnosed prediabetes and type 2 diabetes mellitus

Taslipinar Abdullah , Taslipinar Mine Y , Azal Omer , Sahin Mustafa , Kebapcilar Levent , Ozdemir Levent , Savashan Cagatay , Uckaya Gokhan , Koz Cem , Yaman Halil , Acikel Cengizhan , Kutlu Mustafa

The relation between obesity and diabetes mellitus is known for long periods and this relation is based on insulin resistance. Recent studies showed that epicardial adipose tissue thickness measured by echocardiography is the marker of the visceral adipose tissue and cardiovascular risk. Visfatin is a new described adipokine and it has been showed to have mRNA expression in epicardial adipose tissue. There is a conflict about the role of visfatin on obesity, insulin resistance...

ea0020p370 | Diabetes and Cardiovascular | ECE2009

The relationship between body mass index-left ventricle mass index-myocardial performance index in type 2 diabetes

Oner Fatma Alibaz , Gurcan Zeynep , Uzunhasan Isil , Piskinpasa Mehmet Emin , Erguney Mecdi

Introduction: Diabetes mellitus (DM) has been associated with abnormalities of cardiac function and left ventricular hypertrophy. Diabetic individuals, particularly women, had higher heart rates, greater left ventricular wall thicknesses, greater cardiac mass than unaffected subjects. We aimed to investigate association between waist circumference–body mass index (BMI) and left ventricle mass (LVM)-left ventricle mass index (LVMI), left ventricle myocardial perfusion inde...

ea0020p371 | Diabetes and Cardiovascular | ECE2009

Correlation between serum 25 hydroxy vitamin D3 and laboratory risk markers of cardiovascular diseases in type 2 diabetic patients

Bonakdaran Shokoufeh , Varasteh Abdol-Reza

Background: Vitamin D deficiency is prevalent worldwide. Low 25 hydroxyvitamin D3 concentration inversely associate with type 2 diabetes, metabolic syndrome, insulin resistance, and probably cardiovascular disease. The objective was the evaluation of association between vitamin D deficiency and cardiovascular risk factors among some diabetic patients.Methods and materials: One hundred and nineteen type 2 diabetic patients in IRAN from December to March 2...

ea0020p372 | Diabetes and Cardiovascular | ECE2009

N-acetylcysteine is able to reduce the oxidation status and the endothelial activation after a high-glucose content meal in patients with type 2 diabetes mellitus

Masha Andi , Brocato Loredana , Dinatale Stefano , Mascia Cinzia , Biasi Fiorella , Martina Valentino

Introduction: Post-prandial hyperglycaemia seems to play a pivotal role in the pathogenesis of cardiovascular complications of diabetes mellitus, as it leads to oxidative stress which in turn causes reduced NO bioavailability that produce endothelial activation.Aim: Aim of the study was to assure that the administration of N-acetylcysteine (NAC), thiolic antioxidant, is able to decrease oxidation status and endothelial activation after a high-gluc...

ea0020p373 | Diabetes and Cardiovascular | ECE2009

Hyperhomocysteinemia may be a risk factor for diabetic foot ulcer development

Solmaz Soner , Erdogan Mehmet , Kulaksizoglu Mustafa , Ganidagli Sencer , Kosenli Aybike , Sakalli Hakan , Canataroglu Abdullah

Background: Diabetic foot ulcer and lower extremity amputation are leading causes of mortality and morbidity in diabetic patients. Diabetic neuropathy and peripheral vascular disease are major reasons for diabetic foot ulcer. Most of the studies showed that hyperhomocystinemia is related with microvascular and macrovascular complications in diabetic patients. Also hyperhomocysteinemia is related to poor ulcer healing. In this study, we investigated the relationship of hyperhom...

ea0020p374 | Diabetes and Cardiovascular | ECE2009

Incidence of diabetic ketoacidosis during Ramadan fasting in Benghazi, Libya

Elmehdawi Rafik , Ehmida Mohammad , Elmagrehi Hanan

Background: Ramadan is the ninth month on the lunar calendar and for over a billion Muslims it is a holy month during which all healthy adults must observe absolute fasting from dawn to sunset. The risk of diabetic ketoacidosis is thought to be higher during Ramadan fasting due to hormonal disequilibrium.Aim and objectives: The aim of this study was to examine the hypothesis that diabetic ketoacidosis is more frequent during Ramadan fasting.<p class=...

ea0020p375 | Diabetes and Cardiovascular | ECE2009

ECoRI polymorphism but not XBaI polymorphism of apolipoprotein B gene is associated with carotis intima media thickness in type 2 diabetic patients

Yuksel Meral , Sancak Seda , Yazici Dilek Dereli , Ozben Beste , Gogas-Yavuz Dilek , Akalin Nefise Sema

ApoB plays a central role in lipoprotein metabolism through regulation of total cholesterol and LDL-cholesterol (LDL-C) concentrations in plasma. Two restriction fragment length polymorphisms (ECoRI and XbaI) represent single base alterations in the coding region of ApoB gene. ECoRI polymorphic region of ApoB gene is due to on an amino acid change (Glu→Lys). The XbaI polymorphic region of ApoB gene results from a substitution of (A→T) in the threonine codon and doe...

ea0020p376 | Diabetes and Cardiovascular | ECE2009

Insulin-loaded lipid nanospheres surfaced with polysaccharides for oral delivery

Souto Eliana B , Souto Selma B

Insulin delivery through oral route requires protein protection against gastric environment followed by intestinal absorption. Several approaches using colloidal carriers have been proposed to achieve such attempts. Examples are nanoparticles produced from lipid materials (mono, di and triacylglycerols, waxes, fatty acids), polymeric materials (poly acid lactic/glycolic co-polymers, poly-epsilon caprolactone) or from polysaccharides (hyaluronic acid, dextran sulphate, alginate...

ea0020p377 | Diabetes and Cardiovascular | ECE2009

Influence of admission plasma glucose level on short and long-term prognosis in patients with ST-Segment elevation myocardial infarction

Mladenovic Violeta , Djukic Aleksander , Jovic Marina , Zdravkovic Vladimir , Rosic Mirko

High admission plasma glucose (APG) levels after ST-segment elevation acute myocardial infarction (STEMI) are common and associated with an increased risk of death in subjects with and without known diabetes.Aim: The aim of this study is to analyse the short and long term prognostic significance of APG in patients with STEMI with and without diabetes.Material and methods: This study included all patients registered in Coronary Unit...

ea0020p378 | Diabetes and Cardiovascular | ECE2009

The effect of glycemic control on mean platelet volume in patients with type 2 diabetes mellitus

Gursoy Alptekin , Anil Cuneyd , Ayturk Semra , Nar Asli , Tutuncu Neslihan Bascil

Objective: Morphologic and functional platelet abnormalities have been previously reported in patients with type 2 diabetes mellitus (DM) and some of these abnormalities have been linked to increased cardiovascular risk. Mean platelet volume (MPV) informs not only about platelet size, but also about its functions. Larger platelets bear more thrombotic potential. Higher MPV values have been correlated with cardiovascular events in the short and long run. Previous studies have d...

ea0020p379 | Diabetes and Cardiovascular | ECE2009

Association between APOE genotype and hsCRP in Iranian population: Tehran, lipid and glucose study

Daneshpour Maryam , Behnami Sara , Hedayati Mehdi , Azizi Fereidoun

Introduction: High sensitive CRP (hsCRP) has been reported to associate with an increased risk of cardiovascular disease. There is some evidence on apoE polymorphism in relation to the parameters of inflammation. We have investigated the association between APOE genotypes and hsCRP levels in an Iranian population.Materials and methods: We performed a cross-sectional study of 966 subjects (419 men and 547 women) from the Tehran Lipid and Glucose Study. hs...

ea0020p380 | Diabetes and Cardiovascular | ECE2009

Ca 19-9 levels in type 2 diabetes mellitus patients

Gul Kamile , Nas Sevinc , Sen Didem Ozdemir , Gumus Mehmet , Ersoy Reyhan , Cakir Bekir

Background: Ca 19-9 is a tumor-associated antigen. In this study, we aimed to compare Ca 19-9 levels in type 2 diabetes mellitus (DM) patients and healthy control group.Method: Two hundred and fifteen type 2 DM patients (82 male and 133 female) and 209 healthy control group (79 male, 130 female) age, sex and body mass index(BMI) matched were included in the study. Duration of diabetes, HbA1c and presence of complications were analyzed. Cases with high se...

ea0020p381 | Diabetes and Cardiovascular | ECE2009

Plasminogen activator inhibitor 1 and atherosclerosis in diabetes mellitus type 2

Ilic Sanja , Kostic Nada , Caparevic Zorica , Radojkovic Jana , Jelic Svetlana , Marina Djordje

Background and aims: Plasminogen activator inhibitor -1 (PAI-1) increases in diabetes and this might contribute to decreased fibrinolisis and accelerated atherosclerosis. PAI-1 is also contributor to the development of acute myocardial infarction. Measurement of intimal medial thickening (IMT) is indicator of presence and extent of coronary artery disease. Aim of the study was to find association between PAI-1 marker of decreased fibrinolisis and atherosclerosis by measuring I...

ea0020p382 | Diabetes and Cardiovascular | ECE2009

Combined treatment in childhood diabetes could influence remission period

Saranac Ljiljana , Zivanovic Snezana , Kostic Gordana , Bjelakovic Bojko , Novak Martin

Background: The most striking change in diabetes over recent years has been the convergence of previously distinctive phenotypes. Recently diagnosed children are younger, taller and with greater BM. Pediatric endocrinologists are facing with children presenting mixed signs of both diabetes types. So called hybrid diabetes, or type 1½ has insulin resistance in type 1 phenotype and vice versa autoimmunity in obese children.Patients and methods: Ten ch...

ea0020p383 | Diabetes and Cardiovascular | ECE2009

Impact of age, gender, DM duration and BMI on metabolic control of T2DM patients in Jordan

Haddad Fares , Malkawi Omar , Abdelaziz Abdallah , Srehein Khaldon , Izzat Alia , Qadah Reem , Rifa'i Ala'a , Foqaha Niveen

Aim: To assess the impact of age, sex, duration of diabetes and body mass index confounders on diabetes control in a Jordanian cohort of T2DM at endocrine clinic at KHMC.Patients and methods: Patients randomly selected over 18 months from outpatient clinic at KHMC in Amman-Jordan. Diabetes control assessed by mean of latest 3 HbA1c and FBS. Patients were divided in 2 groups according to age (<55 years vs >55 years), gender, duration (<10 year...

ea0020p384 | Diabetes and Cardiovascular | ECE2009

Retinol binding protein-4 is associated with TNF-α and not insulin resistance in subjects with type 2 diabetes mellitus and coronary heart disease

Al-Daghri Nasser , Al-Attas Omar , Alokail Majed , Draz Hossam , Bamakhramah Ahmed , Sabico Shaun

We studied the association between RBP4 and various markers related to insulin resistance and diabetic complications as well as inflammatory markers in Saudi population suffering from type 2 diabetes and coronary heart disease. Patients with type 2 diabetes were divided into 3 groups according to the type of treatment and involvement of coronary artery disease. Serum TNF-α, insulin, CRP, resistin, leptin and adiponectin were analysed in all samples. RBP4 plasma levels inc...

ea0020p385 | Diabetes and Cardiovascular | ECE2009

Impact of metabolic syndrome, diabetes and prediabetes on cardiovascular events: Tehran Lipid and Glucose Study

Hadaegh Farzad , Shafiee Gita , Ghasemi Asghar , Sarbakhsh Parvin , Azizi Fereidoun

Background and aims: To compare and contrast the cardiovascular disease (CVD) risk associated with the metabolic syndrome (MetS) and dysglycemia, independent of each other, we evaluated the 6.7-year incidence risk of CVD and coronary heart disease (CHD).Methods and results: In an Iranian population, 4018 subjects ≥40 years with no history of CVD at baseline, were followed up for new CHD and CVD events. Incidence rates and hazard ratio (HR) were est...

ea0020p386 | Diabetes and Cardiovascular | ECE2009

NovoMix30® reduces hypoglycemic events with favorable weight change in poorly controlled type 2 diabetes patients: results from Indian cohort of IMPROVE Study

Kalra Sanjay , Unnikrishnan AG , Kumar Ajay , Moharana Ashok , Prusty Vinay , Baruah Manash

Objective: IMPROVE study was designed to assess the safety and effectiveness of NovoMix30® in type 2 diabetes subjects under normal clinical practice conditions.Methods: This large multi-national, open label, prospective, 6 month long observational study captured data for above 50 000 patients started on NovoMix30® with/without oral anti-diabetic drugs (OADs)/other insulin. This paper analyses safety data of 17 995 patient...

ea0020p387 | Diabetes and Cardiovascular | ECE2009

Plasma thrombin-activatable fibrinolysis inhibitor (TAFI) antigen levels in diabetic foot ulcers

Erdogan Mehmet , Solmaz Soner , Canataroglu Abdullah , Kulaksizoglu Mustafa , Cetinkalp Sevki , Ozgen Gokhan , Saygili Fusun , Yilmaz Candeger

Objective: Diabetic foot ulcer is associated with increased morbidity and mortality. The most important factor related to the development of foot ulcer is peripheral neuropathy. Thrombin-activatable fibrinolysis inhibitor (TAFI) is associated with coagulation, fibrinolysis and inflammation. Plasma TAFI may participate in arterial thrombosis in cardiovascular diseases (CVD). TAFI may be involved in the mechanism of vascular endothelial damage in diabetic patients. The aim of th...

ea0020p388 | Diabetes and Cardiovascular | ECE2009

Relationship between adipocytokines and cardiovascular risk factors in patients with type 2 diabetes mellitus

Uslu Sema , Kebapci Nur , Kara Mehmet , Bal Cengiz

Aims: In this study, we examined the relationships between levels of adipocytokines and traditional and non-traditional cardiovascular risk markers in patients with type 2 diabetes mellitus (T2DM).Methods: Serum leptin, resistin, adiponectin, visfatin, high sensitive C-reactive protein (hsCRP), homocystein, asymetric dimethylarginine (ADMA), fasting glucose, insulin, glycated haemoglobin (HbA1C) and full lipid and lipoprotein profile, systolic...

ea0020p389 | Diabetes and Cardiovascular | ECE2009

Prevalence of atopic profile in patients with type 1, type 2 and LADA diabetes mellitus

Hatziagelaki Erifili , Koti Ioanna , Sideri Kyriaki , Makris Michael , Chliva Ekaterini , Economopoulos Theofanis , Kalogeromitros Dimitrios

Background: The existing information about an association between allergic diseases and diabetes mellitus is rather conflicting. However, a few studies demonstrated an inverse relationship between atopic diseases and the risk to develop type1 diabetes mellitus.Objective: The aim of the present study was to analyze the frequency of allergic diseases in patients with type 1, type 2 and LADA (latent autoimmune diabetes in adults) diabetes mellitus and to ev...

ea0020p390 | Diabetes and Cardiovascular | ECE2009

Prevalence of cardiovascular risk polymorphisms and its association with microvascular complications in an adolescent type 1 diabetes population

Melo Miguel , Fagulha Ana , Barros Luisa , Santos Jacinta , Vieira Alexandra , Carvalheiro Manuela

Objectives: To determine the prevalence of several polymorphisms associated with increased cardiovascular risk in a group of adolescents with T1DM. To study the possible association of some polymorphisms with the occurrence of microvascular complications.Methods: Patients were randomly selected from our outpatient clinic. The following polymorphisms were studied:: ACE Ins/Del, Apo B R3500Q, Apo E2, 3, 4, MTHFR C677T and A1298C, PAI 4G/5G, ITGB3 PL(A1)/(A...

ea0020p391 | Diabetes and Cardiovascular | ECE2009

Visfatin seems not to be related in insulin resistance

Taslipinar Abdullah , Taslipinar Mine Y , Azal Omer , Kebapcilar Levent , Sahin Mustafa , Uckaya Gokhan , Sonmez Y Alper , Kucukerdonmez Ozge , Kutlu Mustafa

Visfatin is a newly discovered adipocyte hormone. Recent studies showed a possible relationship between diabetes mellitus and visfatin level. But the effect of visfatin on the insulin resistance was not well understood. The aim of the present study was to explore the relation of visfatin with insulin resistance in patients with prediabetes and diabetes.We included a total of 128 persons in the study and of these 128 persons, 36 were diabetic, 69 were pre...

ea0020p392 | Diabetes and Cardiovascular | ECE2009

Anthropometric determinants of adiponectin levels in obese and non obese premenopausal women

Silva-Nunes Jose , Duarte Leone , Veiga Luisa , Melao Alice , Brito Miguel , Malheiro Fernando

Background: Adiponectin is an important adipokine to which have been attributed anti-diabetic and anti-atherogenic properties. Excess of abdominal fat deposition is undoubtedly assumed as a cardiometabolic risk factor. It has been hypothesized that peripheral deposition of fat could exert a protective effect in cardiometabolic profile.Aims: To evaluate the influence of anthropometric parameters on adiponectin levels in both obese and normal-weight premen...

ea0020p393 | Diabetes and Cardiovascular | ECE2009

Is brachial artery diameter most significant determinator of the flow-mediated dilatation?

Koroglu Banu Kale , Aydin Zeynep Dilek , Goksu Sema Sezgin , Tamer Mehmet Numan

Endothelial dysfunction is assessed noninvasively by measuring flow-mediated dilation (FMD). However, FMD is strongly dependent on arterial size, which contributes to a wide range of FMD values. It was previously shown that FMD is greater in small arteries, because the shear stimulus during postocclusion hyperemia is greater in small arteries. We aimed to investigate the predictive value of brachial arterial size on FMD in 44–61 years old Turkish women while adjusting for...

ea0020p394 | Diabetes and Cardiovascular | ECE2009

General and central obesity and risk of cardiovascular disease: results of the 7.6-year follow-up study in Iranian men

Zabetian Azadeh , Hadaegh Farzad , Azizi Fereidoun

Objective: Although body mass index (BMI) is commonly used to assess risk for cardiovascular disease (CVD), there is an obvious need for prospective studies of different ethnics to evaluate the predicting power of various obesity variables for CVD outcomes.Methods: The study population consisted of 1931 men aged ≥40 years free of CVD at baseline. After a median follow up of 7.6 years, 254 CVD events occurred. Demographic data were collected at base...

ea0020p395 | Diabetes and Cardiovascular | ECE2009

Prevalence of undiagnosed glucose intolerance changes according to age and gender in Japanese middle aged working people

Kawano Hiroaki , Soejima Hirofumi , Nagayoshi Yasuhiro , Yamabe Hiroshige , Kinoshita Yoshihiro , Ogawa Hisao

Undiagnosed diabetes and impaired fasting glucose, a condition that increases the risk for diabetes, have important health consequence. About one-third diabetes was undiagnosed. Thus, prevalence estimates based on self-report or doctor diagnosed disease are underestimates of total prevalence of diabetes, which includes individuals with both known and undiagnosed type 2 diabetes. To examine the prevalence of undiagnosed glucose intolerance, we did 75 g oral glucose tolerance te...

ea0020p396 | Diabetes and Cardiovascular | ECE2009

Diabetes and obesity associated difference in aggregation platelet capacity

Hlazkova Anastasiya , Yaroshevich Natalya , Romanovskiy Alieksey , Melnik Irina , Pishik Valentina

Diabetes mellitus and abdominal obesity are considered to be risk factors for venous and arterial thrombosis, but till now it still remains unclear, what factor is a primary in the genesis of these abnormalities: fibrinolysis dysfunction, vascular endothelium impairment or pathology of the platelet homeostasis component.Forty-two persons included in the study were primary divided into 3 groups: 1 group – nearly healthy (10 males, 12 females), 2 grou...

ea0020p397 | Diabetes and Cardiovascular | ECE2009

Functional balance in diabetic neuropathy

Ghanavati Tabassom , Yazdi Mohammad Jafar Shaterzadeh , Goharpey Shahin , Arastoo Ali Asghar

Introduction: Proprioceptive loss in diabetic peripheral neuropathy patients (DPN) seems to cause postural imbalance which may affect quality of functions and activities of daily living of these patients.Aim: The aim of this study was to compare functional balance in diabetic neuropathic patients and normal subjects.Methodology: In this case–control study, fifteen patients with DPN (which their neuropathy was diagnosed by Diab...

ea0020p398 | Diabetes and Cardiovascular | ECE2009

Terminalia bellerica (Belliric Myrobalan) stimulates the secretion and action of insulin and inhibits starch digestion and protein glycation

Kasabri Violet , Flatt Peter , Abdelwahab Yasser

Traditional plant treatments have been used throughout the world for the therapy of diabetes mellitus. The aim of this study was to investigate the efficacy and mode of action of Terminalia bellerica Roxb. (Combretacea) used traditionally for treatment of diabetes in India. Terminilia bellerica aqueous extract stimulated basal insulin output and potentiated glucose-stimulated insulin secretion concentration-dependently in the clonal pancreatic beta cell line, BRI...

ea0020p399 | Diabetes and Cardiovascular | ECE2009

The frequency of diabetic retinopathy and relevant factors for prediabetic subjects

Gulcan Erim , Ozcura Fatih , Aydin Sayime , Erbilen Esin , Koral Lokman

Objective: To determine the frequency of diabetic retinopathy in prediabetik individuals and to evaluate the relevant factors.Materials and methods: A total of 118 persons between 20 and 60 years of age attending our internal medicine clinic between January 2006 and March 2008 were recruited for the study. The exclusion criterions were the presence of diabetes mellitus and use of antidiabetic agents. Fasting blood glucose between 100 and 125 mg/dl was de...

ea0020p400 | Diabetes and Cardiovascular | ECE2009

Prognostic values of diabetic retinopathy progression for the assessment of lower limbs and heart muscle perfusion disturbances in patients with diabetes 2

Wieslaw Tryniszewski , Mariusz Gadzicki , Jaroslaw Kusmierczyk , Roman Gos , Jacek Rysz , Zbigniew Maziarz

Introduction: Diabetic retinopathy and lower limbs and heart muscle perfusion disturbances are important complications in diabetes. Early recognition of diabetic retinopathy and acroangiopathic disturbances reduce the complications frequency.Aim: Correlation of lower limbs and heart muscle perfusion disturbances and diabetic retinopathy progression level in patients with diabetes 2. The assessment to what extend diabetic retinopathy progression level may...

ea0020p401 | Diabetes and Cardiovascular | ECE2009

Association between inflamation markers and metabolic parameters in type 2 diabetic patients, metabolic syndrome, impaired glucose tolerance

Ataman Erdinc , Dokmetas Sebila , Kilicli Fatih , Acibucu Fettah

Impaired glucose tolerance (IGT) and metabolic syndrome (MS) is considered as the pre-diabetic stages. Recently, it has been suggested that inflammation is associated with the components of MS and it may also have a role in the development of type 2 Diabetes Mellitus (DM). The aim of this study was to investigate the effects of inflammation in the pathogenesis of DM.The study groups consisted of 51 patients with type 2 DM, 28 patients with MS, and 26 pat...

ea0020p402 | Diabetes and Cardiovascular | ECE2009

C-reactive protein level early after starting standard treatment of diabetic foot infection is associated with amputation risk

Akinci Baris , Yener Serkan , Yesil Sena , Yapar Nur , Kucukyavas Yasin , Comlekci Abdurrahman , Eraslan Sevinc , Bayraktar Firat

Prediction of amputation would aid clinicians in the management of the diabetic foot infections. We aimed to assess the predictability of baseline and early post-treatment levels of acute phase reactants on the outcome of patients with diabetic foot infections.In this study, we included patients with infected diabetic foot ulcers who were hospitalized in Dokuz Eylul University Hospital between January 2003 and January 2008, of which data were collected p...

ea0020p403 | Diabetes and Cardiovascular | ECE2009

Use of metformin in pregnancy: a survey of Turkish physicians’ attitudes

Akinci Baris , Tosun Pinar , Bekci Emine , Yener Serkan , Demir Tevfik , Yesil Sena

Although metformin crosses placenta, there is no current evidence whether the use of metformin in pregnancy is associated with increased risk of fetal and maternal complications. The aim of this present study is to investigate the attitudes of Turkish physicians in different specialties in terms of metformin use in pregnancy.Current opinions were assessed by interviewing physicians using a questionnaire. Nine hundred forty physicians were invited to join...

ea0020p404 | Diabetes and Cardiovascular | ECE2009

Predictors of amputation in diabetic foot ulcer: single centre experience in a large Turkish cohort

Yesil Sena , Akinci Baris , Yener Serkan , Bayraktar Firat , Karabay Ozalp , Havitcioglu Hasan , Yapar Nur , Atabey Atay , Kucukyavas Yasin , Comlekci Abdurrahman , Eraslan Sevinc

Background: Prediction of diabetic foot ulcer outcome might be helpful for clinicians in optimizing individual treatment strategy. The aim of the present study was to determine potential benefits of easily assessed clinical and laboratory factors at baseline in the prediction of the outcome in patients with diabetic foot ulcers.Methods: In this observational study, data was collected prospectively in 670 consecutive diabetic foot ulcer episodes in 510 pa...

ea0020p405 | Diabetes and Cardiovascular | ECE2009

The prevalence of anemia in Iranian type 2 diabetic patients and the role of nephropathy

Bonakdaran Shokoufeh , Vahedian Mohammad , Gharebaghi Mohammad

Background: Anemia is a common problem in diabetic patients. Diabetic patients have a greater degree and severity of anemia for their level of renal impairment compared to non-diabetic patients. This study examines the prevalence of anemia in type 2 diabetic patients and to determine the contribution roles of different stages of nephropathy in development of anemia in this patient.Methods and materials: Of 1962 outpatients type 2 diabetes were selected. ...

ea0020p406 | Diabetes and Cardiovascular | ECE2009

Frequency of hypogonadism in men with type 2 diabetes

Ghaderian Bahman , Afkhamizadeh Mozhgan , Rajabian Reza , Khajeh Dalouei Mohammad , Ayatollahi Hosein , Ghareh Sahar

Introduction: Type 2 diabetes is associated with lower total testosterone (TT) levels in cross – sectional studies. However, it is not known whether the defect is primary or secondary.Method: We investigated the prevalence of hypogonadism in type 2 diabetes in men by measuring serum total testosterone (TT), SHBG, LH, FSH, prolactin (PRL) in 85 men with type 2 diabetes. Free testosterone (FT) was calculated by using TT and SHBG (CFT). Hypogonadism wa...

ea0020p407 | Diabetes and Cardiovascular | ECE2009

Is testosterone therapy safe for cardiovascular system? The impact of cardiac ultrasound monitoring

Uryadnova Marina , Kalinchenko Svetlana , Tishova Yuliya , Mskhalaya George , Vorslov Leonid , Saad Farid

Background: The benefit of testosterone replacement therapy in men with hypogonadism nd metabolic syndrome is known. Safety of testosterone therapy is still a question of a high interest, especially regarding influence on cardiovascular system.Objective: To study the safety of testosterone therapy in hypogonadal men with metabolic syndrome based on cardiac ultrasound data.Methods: We studied 39 men aged 35–69 with hypogonadism...

ea0020p408 | Diabetes and Cardiovascular | ECE2009

Effects of alteration in serum testosterone levels on beta cell functions in male patients with hypogonadism and in female patients with polycystic ovary syndrome

Uckaya Gokhan , Bolu S Erol , Ozgurtas Taner , Erbil M Kemal , Kutlu Mustafa

While low testosterone levels are associated with higher incidence of type 2 diabetes mellitus in males. In contrast, hyperandrogenism is associated with higher risk of type 2 diabetes mellitus in females.We, therefore, have assessed alterations in beta-cell functions before and after testosterone replacement therapy in male patients with idiopathic hypogonadotropic hypogonadism (IHH) and before and after anti-androgen therapy in patients with polycystic...

ea0020p409 | Diabetes and Cardiovascular | ECE2009

Endothelium dependent hemostatic factors and subclinical inflammation in women with previous gestational diabetes mellitus

Demir Tevfik , Eraslan Sevinc Biberoglu , Yener Serkan , Akinci Baris , Ali Ozcan Mehmet

Women with a history of GDM may be at increased risk for future diabetes and cardiovascular disease. The aim of this study was to investigate the endothelium dependent hemostatic factors as well as the parameters of endothelial function and inflammation in women with pGDM.Eighty women with pGDM and 40 women (control) healthy women with normal glucose tolerance during pregnancy were studied. In all women, plasma glucose, insulin, C-peptid, lipid profile, ...

ea0020p410 | Diabetes and Cardiovascular | ECE2009

Metabolic syndrome and meal stimulated C-peptide levels as useful clinical markers in choosing metformin for combination therapy with sulphonylurea in type 2 diabetic subjects

Koprivica Branka , Zivkovic Teodora Beljic

Introduction: Monotherapy failure in diabetes mellitus type 2 occurs early in the course of disease. Evaluation of the primary pathogenetic mechanism is of primary importance in choosing the optimal combination therapy.Objectives: To investigate influence of meal stimulated C-peptide levels and HOMA B, as markers of residual insulin secretion on the efficasy of adding metformin to sulphonylurea therapy in subjects with metabolic syndrome, type 2 diabetes...

ea0020p411 | Diabetes and Cardiovascular | ECE2009

: Abstract unavailable....

ea0020p412 | Diabetes and Cardiovascular | ECE2009

Clinical characteristics and mother-fetal results in patients with gestational diabetes

Morales Cristobal , Martinez de Pinillos Guillermo , Garcia-Quiros Juan M , Tome Monica , Fernandez Ignacio , Serrano Isabel , Sendon Angel

Objective: To evaluate the main clinical characteristics and the obstetrical results of perinatal morbi-mortality of women with gestacional diabetes in our Service.Material and method: We made a descriptive study of 83 gestational diabetes patients which became a pursuit coordinated between the services of Endocrinology and Gynecology. The following main aspects were analyzed: age, toxic habits, BMI pre-gestational, first pregnancy or not, previous antec...

ea0020p413 | Diabetes and Cardiovascular | ECE2009

Quality of life in diabetes mellitus: conditional issues of treatment and coping strategies

Pereira Miguel , Neves Celestino , Pereira Joao , Carqueja Eduardo , Alves Marta , Carvalho Davide , Coelho Rui , Medina Jose

Introduction: Quality of life (QoL) is a subject of increasing interest in the health context. Applied to a chronic condition like diabetes, this issue could give an overall perspective of the health outcome.Objective: To evaluate the coping mechanisms, the treatment issues and its contribution to QoL of diabetes patients.Patients and methods: We gathered a sample of 94 diabetic subjects, 50% males, 55.3% type 1, with a mean age of...

ea0020p414 | Diabetes and Cardiovascular | ECE2009

Thyroid dysfunctions and serum creatine kinase levels in statins-using patients with hyperlipidemia

Bayraktaroglu Taner , Ozkaya Mesut , Kutluturk Faruk , Azezli Adil Dogan , Orhan Yusuf

Introduction: Hypothyroidism is a well-known cause of secondary dyslipidemia, and its link to atherosclerosis has been known for long time. The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) offer important benefits for the large population of individuals at high risk for coronary heart disease. It was aimed to invastigation the relations of the secondary hyperlipidemia included overt and subclinical hypothyroidism and increased serum creatine k...

ea0020p415 | Diabetes and Cardiovascular | ECE2009

Histopatological effects of stress on the heart muscle in rats

Demirci Tuba , Ozbek Elvan

Objective: Stress causes negative effects at all the body especially the heart. As a result of the damage of secreting various hormones which stress cause to secrete in the body. During the stress, respiration, tension, heart speed and catecholamine level increase. All these can be considered as a risk factor for the heart disease. In our study, we aimed to examine stress’ possible histopathological changes on heart muscle.Methods: Eight adult femal...

ea0020p416 | Diabetes and Cardiovascular | ECE2009

Insulin casts in type 2 patients different shadows with proliferate retinopathy and those with wtent or bypass on coronary rrteries

Tesic Dragan , Pantelinac Pavle , Mitrovic Milena , Vukovic Bojan

Background and aims: The aim of this study was to examine the prevalence of neuropathy and nephropathy in patients with type 2 (T2DM) complicated by proliferate retinopathy (PDR) and coronary artery occlusive disease (CAOD) treated with stent or bypass surgery.Materials and methods: Comparisons were made between 22 patients with T2DM and bypass or stenting of coronary arteries with normal fundoscopic finding (G1) and 21 age matched controls without diabe...

ea0020p417 | Diabetes and Cardiovascular | ECE2009

Evaluation of the severity of hepatic steatosis in type 2 diabetes

Ben Salem Hachmi Leila , Ben Farhat Leila , Waghlani Ridha , Bouzid Chiraz , Hendaoui Lotfi , Ben Slama Claude

Objective: The objective of this study was to examine the factors influencing the severity of hepatic steatosis in type 2 diabetes.Methods: Computed tomography imaging was used to assess hepatic fat content in 80 men and women with type 2 diabetes. Inclusion criteria included a confirmed diagnosis of type 2 diabetes (≥1 year of duration), without history of hepatic disease or daily consumption of alcohol drink. The ratio of liver to spleen attenuat...

ea0020p418 | Diabetes and Cardiovascular | ECE2009

Microalbuminuria and cardiovascular risk in diabetic patients

Nelaj Ergita , Gjata Margarita , Tase Mihal

Background: Microalbuminuria was originally established as a predictor of renal failure and an independent risk factor for cardiovascular disease in patients with diabetes mellitus as well as in general population. The aim of our study is to assess the relationship between microalbuminuria and the other risk factors in diabetics and their prevalence.Methods: Sixty five patients, 22 men and 43 women with mean age 58.6±10.09, with type 2 diabetes, wer...

ea0020p419 | Diabetes and Cardiovascular | ECE2009

Type 2 diabetes mellitus: failure to recognize cardiovascular risk jeopardizes prevention of diabetes complications in type 2 diabetic patients in daily practice

Jungmann Eckart , Jungmann Gisela

There are still considerable deficits in the prevention of cardiovascular diabetes complications as in effective antihypertensive treatment in type 2 diabetic patients in daily practice. There is controversy, however, to which extent lack of information regarding potential risk factors or deficits in disease awareness of the patients themselves contributes to this unfavourable situation.In 45 female and 51 male type 2 diabetic patients, age, 56+16...

ea0020p420 | Diabetes and Cardiovascular | ECE2009

Prevalence of diabetic retinopathy and its relation with other risk factors

Nelaj Ergita , Gjata Margarita , Lilaj Ilda , Bare Orledia , Sadiku Edite , Collaku Ledio , Klosi Jola , Tase Mihal

Background: Micro and macroangiopathy are two major complications of diabetes. Diabetic retinopathy (DR) and nephropathy (ND) which represented microangiopathy, are present early in type 2 diabetes. Macroangiopathy represented by atherosclerotic process assessed through intima-media thickness (IMT) of carotid artery. Microalbuminuria (MI) predictor of ND is associated with DR in type II diabetic patients and is a reliable marker of DR. The aim was to search for association bet...

ea0020p421 | Diabetes and Cardiovascular | ECE2009

Screening of the Romani population in Serbia for diabetes

Beljic Zivkovic Teodora , Zivkovic Rodoljub , Ignjatovic Toma , Marjanovic Milica , Soldatovic Ivan , Prgomelja Stela , Koprivica Branka , Ackovic Dragoljub

It is well known that Romani people suffer from respiratory and cardiovascular diseases. The aim of our study was to investigate the prevalence of diabetes in the Romani population in Serbia.Methods: During the period October 2006–May 2008, diabetes association of Serbia performed blood glucose measurements in 11 urban and 8 rural Romani communities in Serbia. Blood glucose values, name, age, presence of diabetes, family history for diabetes, time o...

ea0020p422 | Diabetes and Cardiovascular | ECE2009

Thyrotropin and thyroxine are associated with fasting insulin and insulin resistance in euthyroid impaired glucose tolerant subjects

Farasat Tasnim , Cheema Abdul Majeed , Khan M Naeem

Objective: To investigate the relationship of thyroid hormones and insulin secretions in glucose homeostasis in impaired glucose tolerant and type 2 diabetic subjects, with normal thyroid functions.Methods: Retrospective cross sectional analysis was carried out on (n=266) impaired glucose tolerant, type 2 diabetics and normal glucose tolerant subjects. Thyrotropin (TSH), total triiodothyronine (TT3), total thyroxin (TT4) and ...

ea0020p423 | Diabetes and Cardiovascular | ECE2009

The effects of Urtica diocia on rat pancreatic β cell

Mobasseri Majid , Aliasgarzadeh Akbar , Bahrami Amir , Niafar Mitra , Najafipoor Frrzad , Zargami Nosratollah

Introduction: Urtica diocia extract has been used for treatment of diabetes mellitus for many centuries. Hypoglycemic effects of U. diocia have been shown in multiple studies. The present study was designed to determinutese the possible mechanisms of hypoglycemic effects of U. diocia on RIN5F Rat Pancreatic β cells.Methods and materials: In cell culture laboratory of Drug Applied Research Center of Tabriz University (Medical Sci...

ea0020p424 | Diabetes and Cardiovascular | ECE2009

Urtica diocia effects on glucose utilization by human muscle cells

Mobasseri Majid , Aliasgarzadeh Akbar , Aghamohammadzadeh Naser , Zargami Nosratollah , Bahrami Amir

Introduction: Urtica diocia extract has been used for treatment of diabetes mellitus for many centuries. Hypoglycemic effects of U. diocia have been shown in multiple studies. The present study was designed to determinate the possible mechanisms of hypoglycemic effects of U. diocia on human muscle cells.Methods and materials: In cell culture laboratory of Drug Applied Research Center of Tabriz University (Medical Sciences) in IRAN hu...

ea0020p425 | Diabetes and Cardiovascular | ECE2009

Effects of oral contraceptives versus no treatment on glucose tolerance and patients’ satisfaction during long time follow up in 69 hirsute patients

Andries Magdalene , Glintborg Dorte , Andersen Marianne

Objective: To evaluate the long term risk for diabetes and insulin resistance in untreated and oral contraceptive (OC) treated hirsute patients.Design: Cross sectional study.Setting: Academic tertiary-care medical centre.Patients: Of 233 Caucasian hirsute women were evaluated during 1997–2002 (baseline) and re-contacted in 2003–2004. Of 159 patients returned questionnaires and 69 attended clinical e...

ea0020p426 | Diabetes and Cardiovascular | ECE2009

The effect of creatinine clearance on the short-term outcome of neuropathic diabetic foot ulcers

Akinci Baris , Yesil Sena , Bayraktar Firat , Kucukyavas Yasin , Yener Serkan , Comlekci Abdurrahman , Eraslan Sevinc

Introduction: Reduced creatinine clearance is related to an increased risk of diabetic foot ulcer development. Wound healing has been reported to be worse in diabetic patients with impaired kidney functions than general diabetic population. This study aimed to investigate the effect of creatinine clearance on the short term outcome of neuropathic diabetic foot ulcers.Materials and methods: Data from 147 neuropathic diabetic foot ulcer episodes were inclu...

ea0020p427 | Diabetes and Cardiovascular | ECE2009

Mean platelet volume in women with previous gestational diabetes and its alteration during pregnancy

Celtik Aygul , Akinci Baris , Demir Tevfik , Yener Serkan , Yesil Sena

Previous gestational diabetes mellitus (pGDM) is associated with insulin resistance which is a well-known risk factor for atherosclerotic diseases. Mean platelet volume (MPV) is an indicator of platelet activation which plays a crucial role in pathogenesis of atherosclerosis.One hundred and five consecutive women with pGDM and 40 healthy women with normal previous pregnancies were included in the study. At the time of enrollment, anthropometric measureme...

ea0020p428 | Diabetes and Cardiovascular | ECE2009

Reduction of major amputations after starting a multidisciplinary diabetic foot care team: single centre experience from Turkey

Yesil Sena , Akinci Baris , Bayraktar Firat , Havitcioglu Hasan , Karabay Ozalp , Yapar Nur , Demirdover Cenk , Yener Serkan , Yalcin Muhittin , Comlekci Abdurrahman , Eraslan Sevinc

Introduction: It is widely recognized that a multidisciplinary team is effective in the management diabetic foot ulcers. Contrary to developed countries, multidisciplinary diabetic foot care teams and/or clinics have not been constructed in most centres in developing countries. The aim of this study was to present our data regarding amputations rates and profiles before and after starting the Dokuz Eylul University multidisciplinary diabetic foot care team.<p class="abstex...

ea0020p429 | Diabetes and Cardiovascular | ECE2009

Prediction of developing metabolic syndrome after gestational diabetes mellitus

Akinci Baris , Celtik Aygul , Yener Serkan , Yesil Sena

It has been shown that women with previous GDM more likely developed metabolic syndrome (MS). This study aimed to determine predictors of the later development of MS in women with previous GDM.One hundred sixty-four consecutive women with previous GDM were evaluated after a mean follow-up of 40.54 months from index pregnancy. Sixty-five lean women with negative screening for GDM were included as a control group. Data regarding antenatal and peripartum ch...

ea0020p430 | Diabetes and Cardiovascular | ECE2009

Exercise induced oxidative stress in type 2 diabetes: relation to diastolic dysfunction and hypertension

Kostic Nada

Background: Lipid peroxidation and antioxidant systems are important factors affecting the oxidation of lipoproteins. Left ventricular dysfunction and hypertension are much more common in subjects with type 2 diabetes mellitus and limit exercise performance.Aims: The aim of our study was to evaluate the oxidative stress in patients with diabetes mellitus type 2 and to determine influence of acute exercise training on the investigated parameters.<p cl...

ea0020p431 | Diabetes and Cardiovascular | ECE2009

Serum homocysteine levels in diabetes and its relationship to nephropathy

Afkhamizadeh Mozhgan , Ayatollahi Hosein , Abrishami Majid , Musavi Zohreh , Bonakdaran Shokufeh , Aboutorabi Robab , Khajeh Dalouei Mohammad

Introduction: Diabetes is a common disease with many complications; therefore many researches are done on possible factors witch affect on diabetes control and its complications. Homocysteine is one of these possible factors. We studied correlation of homocysteine and diabetes. We also compared homocysteine levels in diabetic patients with nephropathy and patients without nephropathy.Materials and methods: Of 105 diabetic patients and 32 controls were en...

ea0020p432 | Diabetes and Cardiovascular | ECE2009

Can testosterone therapy be included into diabetes treatment in men with metabolic syndrome and hypogonadism?

Kalinchenko Svetlana , Saad Farid , Mskhalaya George , Tishova Yuliya

Background: In 1998 the UKPDS study showed that over 10 years of observation there were no significant changes in haemoglobin A1c (HbA1c) in intensive insulin therapy group compared with conventional therapy group. Therefore, we still need new options to treat diabetes. Diabetes mellitus type 2 (DMT2), is one of the MS components. Obesity leads to insulin resistance (IR) and DMT2. Androgen deficiency (AD) is well-known factor to predict the development of diabetes.<p class...

ea0020p433 | Diabetes and Cardiovascular | ECE2009

The effect of telmisartan and irbesartan treatments on insulin resistance of patients with type 2 diabetes and hypertension

Tasli Babursah , Oz Gul Ozen , Tuncel Ercan , Guclu Metin , Kiyici Sinem , Imamoglu Sazi

Hyperinsulinemia that occurs due to insulin resistance play an important role on the development of type 2 diabetes and hypertension. It is shown that apart from their angiotensin II receptor blockage effect, telmisartan and irbesartan can activate intracellular hormone receptor PPARγ. Owing to this dual effect, telmisartan and irbesartan can improve cardiovascular risk factors related to insulin resistance. The aim of this study was to compare the effects of telmisartan ...

ea0020p434 | Diabetes and Cardiovascular | ECE2009

Insulin treatment intensification in daily diabetes hospital

Garcia-Quiros Juan M , Morales Cristobal , Serrano Isabel , Martinez de Pinillos Guillermo , Tome Monica , Fernandez Ignacio , Sendon Angel

Objectives: To verify the results of the insulin treatment intensification in the control of Diabetes Mellitus type 1 and 2 (DM1 and DM2).Methodology: Of 100 diabetic patients (30% DM1 and 70%DM2) derived to Day Diabetes Hospital (DDH) by glycemic decompensation during year 2007 were studied, 45% women and 55% men (we excluded the debut). The average age of the patients was of 35.1 years in DM1 and 64.4 years in DM2. The Hba1c in the first visit and to t...

ea0020p435 | Diabetes and Cardiovascular | ECE2009

Welfare activity in day diabetes hospital in our area: our experience in 2007

Serrano Isabel , Morales Cristobal , Garcia-Quiros Juan M , Fernandez Guillermo , Tome Monica , Fernandez Ignacio , Sendon Angel

Objectives: The daily diabetes hospital (DDH) is a functional device that offers to diabetics a close and customized attention by specialized staff. The objective is to evaluate the welfare activity, the diagnose and educative program of the DDH in 2007.Methodology: The following parameters have been analyzed: attended users, origin, main reason for consultation, previous Hba1c and to the 3 months, number revisions, income avoided, derivation place, tele...