Searchable abstracts of presentations at key conferences in endocrinology
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11th European Congress of Endocrinology

Poster Presentations

Obesity and Metabolism

ea0020p436 | Obesity and Metabolism | ECE2009

Association between visceral fat and cardiovascular disease risk factors

Berker Dilek , Aydin Yusuf , Isik Serhat , Tutuncu Yasemin , Pasaoglu Lale , Delibasi Tuncay , Guler Serdar

Objective: We designed this study to evaluate whether visceral fat area (VFA), and subcutaneous fat area (SFA) are associated with atherosclerotic parameters in obese and non-obese subjects.Material and methods: Of 104 healthy volunteers were recruited for the study. Participitants were divided into two groups according to their body mass index (BMI). Group 1 has a BMI of <25 kg/m2 (n=31) and the BMI of the group 2 was ≥25 kg/...

ea0020p437 | Obesity and Metabolism | ECE2009

Severe hypertriglyceridemia and triglyceride apheresis

Bayraktaroglu Taner , Ozkaya Mesut , Kutluturk Faruk , Azezli Adil Dogan , Orhan Yusuf

Introduction: Patients with extremely high triglyceride levels and associated lipemia are at high risk for acute pancreatitis. Hypertryiglycerideamia can be can be provoked when triglyceride levels exceed 1.000 mg/dl of acute pancreatitis.Materials and method: In 7 patients with hyperlipidemic pancreatitis was evaluated. In addition to the standard therapy, they were treated with triglyceride apheresis. Acute pancreatitis was diagnosed based on the prese...

ea0020p438 | Obesity and Metabolism | ECE2009

Lower dietary acid load is related to a lower incidence of the metabolic syndrome

Bullo Monica , Babio Nancy , Salas-Salvado Jordi

Introduction: Bone metabolism and osteoporotic fractures have been related to inflammatory status and associated to metabolic disorders such as obesity, cardiovascular disease or metabolic syndrome (MS). Evidence suggests that a more acidic diet could be considered detrimental in terms of bone health. Thus, dietary acid load could be associated to the metabolic syndrome evolution.Methods: A longitudinal study was conducted with 282 elderly subjects at hi...

ea0020p439 | Obesity and Metabolism | ECE2009

The evaluation of metabolic effects following ghrelin and salbutamol administration

Benso Andrea , St-Pierre David H , Gramaglia Elena , Riganti Fabrizio , Lucatello Barbara , Olivetti Ilaria , Ghigo Ezio , Broglio Fabio

Background: The activation of the GHS-R1a receptor by acylated ghrelin (AG) or by synthetic GH secretagogues (GHS), potently stimulates GH release and mediates other neuroendocrine/metabolic effects. Beta-adrenergic receptor agonists negatively influence GH secretion and other metabolic functions. The GH response to AG and GHS is refractory to the inhibitory effect of β2-adrenoceptors activation but no other report has evaluated the interactions between AG and salbutamol ...

ea0020p440 | Obesity and Metabolism | ECE2009

TNFR-1 knockout protects against diet induced obesity

Romanatto Talita , Roman Erika A , Denis Rapahel G , Arruda Ana Paula , Milanski Marciane , Degasperi Giovanna , Solon Carina , Velloso Licio A

Abstract: Obesity results from an imbalance between caloric intake and energy expenditure. Specialized neurons of the hypothalamus coordinately control the integration between feeding and thermogenesis and a defective regulation of these parameters contribute to the progressive accumulation of body fat. Recent studies have revealed that at least part of hypothalamic dysfunction contributing to the development of obesity results from the activation of a local inflammatory respo...

ea0020p441 | Obesity and Metabolism | ECE2009

Acute inflammatory biomarker modifications as a result of a single session of submaximal exercises in obese subjects

Caparevic Zorica

Background: Classical risk factors are not capable to explain all the cardiovascular events and new markers are being evaluated to predict events.Aims: We examined the effects of a single session of submaximal exercise (cardiopulmonary exercise cycle ergometer test) on atherogenic lipids in obese subjects focusing on inflammatory biomarker high-sensitivity C-reactive protein (hs-CRP), and oxidized low-density-lipoproteins (oxLDL) as a marker of oxidative...

ea0020p442 | Obesity and Metabolism | ECE2009

Adipokines’ variations due to a lower caloric intake in endocrine obese patients associating the metabolic syndrome

Oros Sabina , Ianas Olga , Lerescu Liviu , Salageanu Aurora , Giurcaneanu Mihaela , Vladoiu Suzana , Dragomir Adina , Gherlan Iuliana , Iconaru Laura , Hristea Ruxandra , Dumitrache Constantin

Adipokines and cytokines have modified values in the metabolic syndrome (MetSyn), without knowing if they are the cause or the effect of insulin resistance. Multiple studies evaluating adipokines and cytokines in MetSyn presented controversial results.The aim of this study was to evaluate adiponectin, leptin, resistin, CRP and TNFα in obese subjects with endocrine diseases that associate insulin resistance before and after a low calorie diet.<p ...

ea0020p443 | Obesity and Metabolism | ECE2009

Influence of metformin on carbohydrate metabolism in young women with metabolic syndrome

Kuliczkowska-Plaksej Justyna , Bednarek-Tupikowska Grazyna , Filus Alicja , Trzmiel-Bira Anna , Bednorz Wlodzimierz , Milewicz Andrzej

Introduction: Metformin (MET) is mainly used in diabetes mellitus type 2 (DM2) therapy. Little is known about its effects in patients with metabolic syndrome (MS) and insulin resistance (IR) without DM2.Aim: To asses the influence of MET on carbohydrate metabolism in young prediabetic women with MS.Materials and methods: The study population: 30 women with MS aged 25–45 years before (M1) and after (M2) ME...

ea0020p444 | Obesity and Metabolism | ECE2009

Letrozole normalizes serum testosterone and reduces body weight in morbidly obese men with obesity-related hypogonadotropic hypogonadism

Loves Sandra , de Jong Jos , van Sorge Adriaan , Telting Darryl , de Boer Hans

Introduction: Hypogonadotropic hypogonadism is frequently observed in morbidly obese men, due to aromatase-dependent conversion of androgens to estrogens in adipocytes. The clinical impact of this sex hormone imbalance is not known.Aim: To evaluate the clinical effects of aromatase inhibition in obesity-related hypogonadotropic hypogonadism.Methods: Double-blind, placebo-controlled trial for 6 months in severely obese men (BMI &#62...

ea0020p445 | Obesity and Metabolism | ECE2009

Effect of metformine treatment on serum paraoxonase and oxidative status in obese women

Fenkci Semin , Karagenc Nedim , Akin Fulya

Objective: To evaluate the effects of metformine newly using in clinical practice to ameliorate insulin resistance on paraoxonase activity and oxidative stress in obese insulin resistant women.Materials and methods: Sixty-seven obese (BMI≥30 kg/m2) women were enrolled into this study. Serum fasting (F.Glc) and postprandial glucose (P.Glc), insulin, uric acid (UA), paraoxonase (PON1), Arylesterase (AET), malondialdehyde (MDA), cupper-MDA ...

ea0020p446 | Obesity and Metabolism | ECE2009

Serum visfatin concentration in obesity and impaired glucose tolerance – relationship with insulin resistance, blood pressure and proinflammatory factors

Kowalska Irina , Straczkowski Marek , Nikolajuk Agnieszka , Karczewska-Kupczewska Monika , Adamska Agnieszka , Gorska Maria

Visfatin, a protein secreted by the adipose tissue, might regulate insulin action. The aim of the present study was to assess serum visfatin concentration in obese women with normal glucose tolerance (NGT) and impaired glucose tolerance (IGT) and to estimate the relationships between serum visfatin concentration and insulin sensitivity, blood pressure, proinflammatory and proatherogenic factors.The study group consisted of 134 women: 30 overweight or obe...

ea0020p447 | Obesity and Metabolism | ECE2009

Intracerebroventricular leptin increase AKT phosphorylation stimulated by insulin in skeletal muscle: the role of adrenergic signal and JAK2 activation

Roman Erika Anne , Reis Daniel , Romanatto Talita , Maimoni Denis , Solon Carina , Morari Joseane , Velloso Licio Augusto , Torsoni Marcio Alberto

Leptin is an adipocyte-derived hormone that acts directly in the brain reducing food intake, increasing glucose uptake and modulating the metabolism in adipose tissue. Nevertheless, the central mechanisms related to improve glucose uptake, induced by leptin intracerebroventricular (icv), and the proteins activated in the skeletal muscle are incompletely understood. The aim of this study was to investigate the mechanism by which ICV leptin increase glucose uptake and improve gl...

ea0020p448 | Obesity and Metabolism | ECE2009

Evidence of increased cardiovascular risk in patients with non-secreting unilateral adrenocortical adenomas

Androulakis Ioannis , Kollias George , Markou Athina , Papanastasiou Lambrini , Angnostou Tilemachos , Papamichael Christos , Piaditis George , Kaltsas Gregory

Background: Incidentally discovered adrenal adenomas (AA) are associated with increased prevalence of hypertension, obesity, and impaired glucose tolerance, all established risk factors for cardiovascular (CV) morbidity. However, most studies were performed in patients with AA and autonomous cortsisol and/or aldosterone secretion, whereas the presence of cardiovascular risk in patients with non-secreting AA has not been looked into detail.Methods: Cardio...

ea0020p449 | Obesity and Metabolism | ECE2009

Metabolic syndrome highly correlates to non toxic multinodular goiter progression: iperinsulinism a way to growth

Citarrella Roberto , Chiofalo Francesco , Vetro Calogero , Lo Coco Alessio , Puleo Luciana

Background: Insulin-resistance phenomenon is a key factor in the pathogenesis of Metabolic Syndrome (MS). Several reports focus on the identification of a role of Insulin to trigger thyrocytes proliferation in vitro. Thyroid IRS-1 mRNA expression increased progressively during goitrogenesis in vivo. In order to individuate the impact of clinical and biochemical markers of MS on the growth-score of non toxic multinodular goiter (MNG) we evaluated a population of 6...

ea0020p450 | Obesity and Metabolism | ECE2009

IGF-1 gene polymorphism in obese patients with insulin resistance

Yaylali Guzin Fidan , Akin Fulya , Turgut Sabahat , Kursunluoglu Raziye

Objective: Insulin like growth factors (IGFs) are important regulators of pancreatic β cell devolopment, growth and maintanence. Mutations in the IGF genes have been found to be associated with type 2 diabetes, myocardial infarction, birth weight and obesity. These associations could result from changes in insulin secretion. We aimed to investigate IGF- 1 gene polymorphism in obese patients with insulin resistance.Methods: We included 100 obese pati...

ea0020p451 | Obesity and Metabolism | ECE2009

Familial obesity and the role of nutrition

Zavareh Maryam Beheshti , Sadeghian Saeid , Mirmiran Parvin , Hosseini Firoozeh

Goal: To study the relation between the obesity of children and their parents, and energy intake.Materials and methods: Of 236 households containing 828 population (356 children age 5–25 years, and the rest their parents) were selected from the subjects of ‘Tehran Lipid and Glucose study’ (2006–2008) for this study. Food intake of the subjects was studied using FFQ. In this study, energy intake ≥75 percentile was regarded as &#1...

ea0020p452 | Obesity and Metabolism | ECE2009

Adiponectin and vascular properties in obese patients: is it a novel biomarker of early atherosclerosis?

Wolfson Ninel , Goldberg Yffat , Shargorodsky Marina

Objective: Adiponectin is an adipocyte-derived collagen-like protein, highly specific to adipose tissue and may represent an important link between obesity and atherosclerosis. The present study was designed to investigate a possible association between serum adiponectin levels and early vascular changes in obese patients as determined by intima media thickness (IMT) and arterial pulse-wave contour analysis.Design: Obese subjects (n=47) were evalu...

ea0020p453 | Obesity and Metabolism | ECE2009

A comparison of serum leptin levels and metabolic parameters included serum lipoproteins and glucose homeostasis between national wrestlers and healthy males

Yamaner Faruk , Bayraktaroglu Taner , Atmaca Hulusi , Ziyagil MehmetAkif , Tamer Kemal

Background and aim: Wrestling success depends on power, power endurance, and maximum strength, muscular endurance of short duration, flexibility as well as technique and tactical skills. Weight control and weight loss are also very important issues in the view of wrestling success. In this study, it was aimed to investigate the anthropometric features, serum lipoproteins, glucose homeostasis and leptin levels in Turkish National Senior Wrestlers and healthy sedentary males.</p...

ea0020p454 | Obesity and Metabolism | ECE2009

Impact of protein content of low-carbohydrate/high-fat diets upon ketosis, energy expenditure and glucose utilization in rats

Bielohuby Max , Kienzle Ellen , Tschop Matthias H , Hoeflich Andreas , Bidlingmaier Martin

Maintenance of ketosis and increases in resting energy expenditure (EE) are two proposed mechanisms for weight loss observed in humans performing low-carbohydrate/high-fat (LC-HF) diets like the Atkin’s diet. To explore these potential mechanisms, we pair-fed isocaloric amounts of regular chow (CH) or two LC-HF diets (carbohydrates~1%ME) to male Wistar rats for 4 weeks. LC-HF-1 (fat~66%ME) was matched in protein content to CH, whereas LC-HF-2 was even higher in fat (~94%M...

ea0020p455 | Obesity and Metabolism | ECE2009

Thyroid function tests, measures of adiposity and metabolic syndrome in apparently healthy euthyroid individuals

Saltiki Katerina , Stamatelopoulos Kimon , Voidonikola Paraskevi , Mantzou Emily , Papamichael Christos , Alevizaki Maria

Objective: Thyroid function tests (TFTs) have been associated with obesity; however associations with the type of adiposity have not been examined. Ultrasound (U/S) was used to assess regional adiposity in euthyroid individuals. Associations of thyroid function with obesity parameters and presence of the metabolic syndrome (MS) were investigated.Methods: Of 302 apparently healthy slightly overweight individuals (age 42.9±8.8, BMI 19.0–43.3, med...

ea0020p456 | Obesity and Metabolism | ECE2009

25-Hydroxyvitamin D is associated with insulin resistance, obesity, and serum lipids in polycystic ovary syndrome

Wehr Elisabeth , Pilz Stefan , Schweighofer Natascha , Giuliani Albrecht , Kopera Daisy , Pieber Thomas R , Obermayer-Pietsch Barbara

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting about 5-10% of women. PCOS is characterized by hyperandrogenism, ovulatory disturbances, and polycystic ovaries. Many women with PCOS present with insulin resistance and central obesity and are at an increased risk for developing diabetes and cardiovascular disorders. Vitamin D deficiency is an important pathogenetic factor in the development of type II diabetes. The aim of the study was to...

ea0020p457 | Obesity and Metabolism | ECE2009

Chronic renal disease, hyperfiltration, metabolic syndrome and hypogonadism: is there a link?

Tishova Yuliya , Kalinchenko Svetlana , Novikova Maria , Shilov Evgeniy , Borisov Vladimir , Saad Farid

Introduction: Hyperfiltration (HF) is an early marker of chronic renal disease (CRD), which is prevalent in 10–15% of MS patients\. Taking into account the benefit of testosterone replacement towards MS components in men with MS and hypogonadism, we can expect the same benefit on HF.Objective: To study the role of hypogonadism correction in patients with MS and hyperfiltration.Methods: Of 71 men aged 35–69 with MS (IDF cr...

ea0020p458 | Obesity and Metabolism | ECE2009

Changes in serum levels of fetal antigen 1 (FA1/Pref-1/Dlk1) in extreme nutritional states

Andries Alin , Stoving Rene , Wolf Andrea , Beisiegel U , Horder Kirsten , Martin SB , Abdallah BM , Kassem Moustapha

Background: Also known as preadipocyte factor 1 (pref-1) or delta-like 1 (Dlk1), fetal antigen 1 (FA1) was originally isolated from amniotic fluid and it is involved in tissue homeostatis during development and tissue regeneration in the post-natal organisms. FA1 may also plays a role in energy metabolism since mice deficient in FA1 are obese and mice overexpressing FA1 exhibit a lipodystrophy phenotype.In our study we determined FA1 serum levels in pati...

ea0020p459 | Obesity and Metabolism | ECE2009

Influence of metformin on selected lipids and apolipoproteins concentrations in young women with metabolic syndrome

Kuliczkowska-Plaksej Justyna , Bednarek-Tupikowska Grazyna , Filus Alicja , Trzmiel-Bira Anna , Milewicz Andrzej

Introduction: Metabolic syndrome (MS) is connected to atherogenic dyslipidemia. Data concerning influence of metformin (MET) therapy on lipid profile in nondiabetic women with MS remains unclear.Aim: To asses the influence of MET on selected lipid, apolipoproteins AI, B concentrations and atherogenic indexes values in young women with MS.Materials and methods: The study population: 30 women with MS aged 25–45 years before (M<s...

ea0020p460 | Obesity and Metabolism | ECE2009

Correlation of leptin, total body fat mass and body fat distribution in overweight postmenopausal women

Dolidze Nino , Giorgadze Ellen , Asatiani Ketevan , Tsagareli Marina , Lomidze Marina , Surmava Arkadi , Bochorishvili Ketevan

We have investigated the leptin production by total and regional fat mass in 32 overweight postmenopausal women as well as the relation between serum leptin levels, total body fat mass and body fat distribution variables. Body mass index (BMI) was calculated in kg/m2. Serum concentrations of leptin were evaluated by RIA. Body composition – trunk/total, arms+legs/total+legs/trunk, android/gynoid ratios were assessed by dual-energy X-ray absorptiometry (DEXA). Th...

ea0020p461 | Obesity and Metabolism | ECE2009

Diabetic patients with abnormal LFTS

Mlawa G , Bodmer C , D'Souza R , Skelly R

Objective: Patients with diabetes mellitus often have abnormal liver function tests without any symptoms. Our aim in this study was to evaluate the frequency and cause of abnormal LFTS in diabetic patients.Methods: 150 patients were enrolled from diabetic clinic who had been diagnosed with diabetes (creatinine,fasting glucose,random glucose, GTT were recorded). The following demographic data were recorded from each patients: age,sex, duration of diabetes...

ea0020p462 | Obesity and Metabolism | ECE2009

Impact of growth hormone receptor blockade on substrate metabolism during short-term fasting in healthy subjects

Moller Louise , Norrelund Helene , Frystyk Jan , Moller Niels , Jorgensen Jens OL

Context and objective: During fasting growth hormone (GH) promotes lipolysis, attenuates glucose oxidation and preserves protein. Previous studies have primarily been conducted in GH deficient patients or during somatostatin-suppression of GH secretion. We aimed to study the impact of the fasting associated increase in GH without concomitant changes in other hormones, by the means of GH receptor (GHR) blockade.Design: Ten healthy young men participated i...

ea0020p463 | Obesity and Metabolism | ECE2009

Are hypothalamic oscillators dysfunctional with high fat feeding?

Namvar Sara , Gyte Amie , Birtles Susan , Myatt John , Leighton Brendan , Piggins Hugh

Circadian rhythms in behaviours and gene expression are driven by the autonomously rhythmic cells of the hypothalamic suprachiasmatic nucleus (SCN). In nocturnal rodents, restricting a daily meal to the lights-on phase, leads to entrainment of behaviour and gene expression in many extra-SCN hypothalamic nuclei and peripheral tissues. This anticipatory activity is independent of the SCN and is likely to arise from the activities of multiple hypothalamic centres including the do...

ea0020p464 | Obesity and Metabolism | ECE2009

Glucose-dependent insulinotropic polypeptide increases glucose-uptake in muscle- and adipocyte cells in vitro

Andres Janin , Biedasek Katrin , Goegebakan Ozlem , Mai Knut , Pfeiffer Andreas , Spranger Joachim

Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone secreted by K-cells of proximal small intestine that is secreted postprandial in response to glucose and fat ingestion. Its effect is mediated through a GIP receptor (GIPR) which is widely expressed in different tissues, e.g. pancreatic islets, adipose tissue, skeletal muscle, adrenal cortex, heart, pituitary and in some regions of the brain. However, only the effect of GIP in pancreatic beta-cells is we...

ea0020p465 | Obesity and Metabolism | ECE2009

Glucose-dependent insulinotropic polypeptide modulates inflammatory markers in adipose tissue

Gogebakan Ozlem , Osterhoff Martin , Mosig Sandy , Middelbeck Ines , Rudovich Natalia , Schuler Rita , Pfeiffer AFH

Background: Glucose-dependent insulinotropic polypeptide (GIP) is a gastrointestinal hormone that is secreted in response to food intake. GIP acts on various tissues, including pancreatic ß-cells, via interaction with its G-protein-coupled receptor. Some studies in rodents suggested that GIP directly links overnutrition to obesity. GIP exerts a physiological role on lipid uptake into adipocytes.Objectives: To analyse the effect of GIP-Infusions on c...

ea0020p466 | Obesity and Metabolism | ECE2009

Glucose RapidSpray™ as adjuvant in diet restriction programmes

Khazrai Yeganeh Manon , Cacciapaglia Fabio , Altomare Maria , Leotta Sergio , Pozzilli Paolo

Overweight and obese subjects often suffer from hypoglycaemic symptoms due to hyperinsulinemia. This increases subjects’ need to eat excessive amount of food enriched in sugar causing rebound hyperglycaemia which in turn stimulates endogenous insulin release perpetuating a vicious circle that limits weight loss under diet restriction programme. Two previous studies showed that administration of Glucose RapidSpray™ (GRS) in quantity of ~ 0.5 g increases blood glucose ...

ea0020p467 | Obesity and Metabolism | ECE2009

Plasma monocyte chemoattractant protein-1 and macrophage inflammatory protein-1α are increased in patients with polycystic ovary syndrome and associated with adiposity, but unaffected by pioglitazone treatment

Glintborg Dorte , Andersen Marianne , Richelsen Bjorn , Bruun Jens

Objective: PCOS patients are often characterized by insulin resistance, abdominal obesity, and low-grade inflammation. Insulin sensitizing treatment reduces the inflammatory state, but the effect on serum levels of chemokines such as migration inhibitor factor (MIF), monocyte chemoattractant protein (MCP)-1, and macrophage inflammatory protein (MIP)-1α have not previously been evaluated in PCOS.Research design and methods: Plasma chemokine levels (M...

ea0020p468 | Obesity and Metabolism | ECE2009

Elevated prolactin serum level in erectile dysfunction cases can be predict by metabolic syndrome

Coca Vasile , Coca Mariana Cecilia

Objective: Comparing serum pituitary hormones prolactin (PRL), luteinizing hormone (LH) and thyrotropin (TSH) to serum total testosterone (TT) in men with erectile dysfunction (ED) and metabolic syndrome (MetS) versus those having ED without MetS.Method: We looked for the prevalence of serum high PRL, high LH, high TSH and low TT levels in 24 men (Gr. A=49.35±5.2 years old) with ED (IIEF-5 questionnaire) and MetS (IDF criteria, 2005) versus t...

ea0020p469 | Obesity and Metabolism | ECE2009

Sexual dysfunction in women with obesity

Yaylali Guzin Fidan , Tekekoglu Selma , Akin Fulya

Objective: Both overweight and obesity have been identified as risk factors for sexual dysfunction in men, but the relationship between female sexual function and amount of body fat is still obscure. To the best of our knowledge there are few reported studies assessing the relation between female sexual function index (FSFI) and body weight in women. Therefore, the aims of this study were to identify the frequency of sexual dysfunction (FSD) among obese women.<p class="abs...

ea0020p470 | Obesity and Metabolism | ECE2009

Effects of green tea consumption on blood pressure, total cholesterol, body weight and fat in healthy volunteers

Al-Dujaili Emad , Bradley Jon-Paul , Almoosawi Suzana , Fyfe Lorna

Background: Hypertension, obesity and hyperlipidemia are key interlinked features of both metabolic syndrome and cardiovascular disease. Numerous studies have suggested that green tea may reduce blood pressure by activating endothelial nitric oxide synthase and reducing total cholesterol by disrupting the production of apo B and synthesis of chylomicrons and thus have cardio-protective effects. The aim of this pilot study was to investigate the effects of increasing the consum...

ea0020p471 | Obesity and Metabolism | ECE2009

Subcutaneous adipose tissue topography and metabolic disturbances in polycystic ovary syndrome

Wehr Elisabeth , Moller Reinhard , Horejsi Renate , Giuliani Albrecht , Kopera Daisy , Schweighofer Natascha , Pieber Thomas R , Obermayer-Pietsch Barbara

Objective: Central obesity plays a major role in the pathophysiology of polycystic ovary syndrome (PCOS). However, little information exists concerning the impact of subcutaneous adipose tissue (SAT) on metabolic disturbances in PCOS. The aim of this study was to investigate whether SAT topography influences insulin resistance, impaired glucose tolerance, and metabolic parameters in PCOS women.Design: Prospective case-control trial.<p class="abstext"...

ea0020p472 | Obesity and Metabolism | ECE2009

Melanocortin-4-receptor gene variants: hotspot or identical by descent?

Grothe Jessica , Brumm Harald , Scherag Andre , Friedel Susann , Hinney Anke , Hebebrand Johannes , Illig Thomas , Grallert Harald , Wiegand Susanna , Krude Heiko , Farooqi Sadaf , Gruters Annette , Biebermann Heike

The melanocortin-4-receptor (MC4R) plays an important role in body weight regulation. Mutations in the MC4R gene are the most common genetic cause for obesity. The most frequent Northern European mutation is Y35X, associated with D37V on the same allele. Furthermore, there are two variants with a relatively high frequency: V103I and S127L. In rare cases, we identified the variants V103I and S127L on the same allele. The occurrence of two variants on the same allele makes a fou...

ea0020p473 | Obesity and Metabolism | ECE2009

Association between platelet count and metabolic risk factors in over weight and obese women

Kutluturk Faruk , Tanyolac Sinan , Azezli Adil , Orhan Yusuf

Introduction: We aimed to evaluate the relationship between platelet count and metabolic risk factors in over weight and obese women in Turkish women.Methods: Over weight (BMI>25 kg/m2) 665 and obese (BMI>30 kg/m2) 4609 women were enrolled into the study. The patients were divided into three group according to the platelet count (PLT), Group I (n=1724) consist of serum PLT≤245×103, group II (n...

ea0020p474 | Obesity and Metabolism | ECE2009

The evaluation of the oxidative stress in obese adolescent girls with full or partial metabolic syndrome

Karamouzis Ioannis , Kanaka-Gantenbein Christina , I Pervanidou Panagiota , Magiakou Maria-Alexandra , Haidich Anna-Betina , Sakka Sofia , Papasotiriou Ioannis , Chrousos George P

Background: Studies in adults have clearly demonstrated that obesity is a main factor implicated in increased oxidative stress and platelet activation, both predisposing factors for cardiovascular disease leading to increased morbidity and mortality. Furthermore, the metabolic syndrome (MetS), the clustering of abnormalities, such as central obesity, dyslipidemia, impaired glucose tolerance and hypertension, which is an important cardiovascular risk factor in adults, is also h...

ea0020p475 | Obesity and Metabolism | ECE2009

The role of family and parental factors in childhood obesity

Solntsava Anjelika , Vishnevskaya Mariya

Poor family functioning will be associated with inadequate parental monitoring and/or regulation of children’s eating and activity patterns. We aimed to examine the relationship between a child’s weight and a broad rang of family and maternal factors. Our hypothesis was that increasing adiposity in children would be associated with poor general family functioning, lower socioeconomic status, inappropriate parenting style. This cross-sectional study involved 56 obese ...

ea0020p476 | Obesity and Metabolism | ECE2009

Relationship of serum gamma-glutamyltransferase and adiposity measures with C-reactive protein in severe obese women

Sumarac-Dumanovic Mirjana , Micic Dragan , Stamenkovic-Pejkovic Danica , Cvijovic Goran , Jeremic Danka , Kendereski Aleksandra

Introduction and aims: Recent epidemiological studies have suggested serum gamma glutamyltransferase (GGT) within its normal range might be an early marker of oxidative stress. Oxidative stress appears to be a key component of many reactions associated with chronic inflammation. Obesity is associated with elevated levels of biomarkers of inflammation and endothelial dysfunction. Oxidative stress and inflammation are also known to play critical roles in the pathogenesis of vasc...

ea0020p477 | Obesity and Metabolism | ECE2009

A retrospective analysis of the relationship of thyroid function with obesity in a single center obesity outpatient policlinic

Oz Gul Ozen , Ersoy Canan , Gul Bulent , Guclu Metin , Ibanoglu Mahmut , Cangur Sengul , Kiyici Sinem , Cander Soner , Unal Oguz Kaan , Erturk Erdinc , Tuncel Ercan , Imamoglu Sazi

The activity of hypothalamic–pituitary axis is increased in obese patients and some hormonal changes can be observed as a consequence. Although the effects of hypothyroidism or hyperthyroidism on weight are clearly demonstrated data regarding the effects of relatively minor defects is limited. There are different results in the literature concerning thyroid function status in obesity, some indicating no change, others elevated serum thyroid stimulating hormone (TSH), free...

ea0020p478 | Obesity and Metabolism | ECE2009

Relationship between prehypertension and metabolic risk markers in over weight and obese women

Kutluturk Faruk , Bayraktaroglu Taner , Azezli Adil , Orhan Yusuf

Introduction: Hypertension is a major risk factor for several cardiovascular diseases including coronary heart disease. Prehypertension is defined systolic blood pressure (SBP) between 120–139 mmHg and diastolic blood pressure (DBP) 80–89 mmHg. Recent studies have documented an increased risk of cardiovascular disease in persons with prehypertension. In this study, we evaluated association between prehypertension and the metabolic risk markers in over weight and obes...

ea0020p479 | Obesity and Metabolism | ECE2009

Short term elevation of estradiol concentrations does not affect hepatic VLDL-TG production

Gormsen Lars C , Host Christian , Gravholt Claus , Christiansen Jens S , Nielsen Soren

Background: Hormone replacement therapy (HRT) in post-menopausal women carries an increased risk of cardiovascular disease due to an unfavorable effect on lipid profile. Thus, HRT treatment increases concentrations of very-low-density-lipoprotein-triglycerides (VLDL-TGs) which have been demonstrated to possess atherogenic properties. However, the exact mechanisms whereby VLDL-TG concentrations are increased by estradiol are not fully understood. Estradiol acts on both rapid re...

ea0020p480 | Obesity and Metabolism | ECE2009

Serum adiponectin levels and polymorphism of CB1 endocannabinoid receptor (A3813G, A4895G, G1422A) in postmenopausal women

Jedrzejuk Diana , Lwow Felicja , Dunajska Katarzyna , Laczmanski Lukasz , Milewicz Andrzej

Recently, low serum adiponectin levels is created as a new risk factor for cardiovascular diseases in climacteric women. Our previous study shows that smoking, serum testosterone levels, blood pressure and BMI have the influence on serum adiponectin levels. Endocannabinoid system plays a role in regulation of food intake and fat accumulation, as well as lipid and carbohydrate metabolism. Menopause transition is related to metabolic disorders (e.g. obesity) and cause the increa...

ea0020p481 | Obesity and Metabolism | ECE2009

Relationships of TNFα system with glucose and lipid oxidation in subjects with different degree of insulin sensitivity

Adamska Agnieszka , Karczewska-Kupczewska Monika , Kowalska Irina , Nikolajuk Agnieszka , Gorska Maria , Straczkowski Marek

One of the key actions of insulin is the regulation of glucose and lipid oxidation. Disturbances in substrate oxidation play an important role in the development of insulin resistance. Insulin action is inversely associated with circulating pro-inflammatory cytokines such as soluble TNF-α receptors (sTNFR1 and sTNFR2).The aim of the present study was to analyze the associations between serum sTNFR1 and sTNFR2 concentrations and glucose and lipid oxi...

ea0020p482 | Obesity and Metabolism | ECE2009

Variation of daytime melatonin levels

Racz Beata , Vondra Karel , Duskova Michaela , Simunkova Katerina , Hill Martin , Starka Luboslav

Melatonin has a key role in circadian timing system. At present, many other functions of melatonin are known. It shows a remarkable functional versatility exhibiting antioxidant (direct free radical scavenging and indirect antioxidant activities), oncostatic, anti-aging, immunomodulatory properties and many other functions. In addition to pineal gland, gastrointestinal tract is the second biggest source of melatonin. Question remains whether changes in endogenous melatonin may...

ea0020p483 | Obesity and Metabolism | ECE2009

Aromatase expression in peripheral blood leukocytes from adult and elderly female and male subjects

Pignatti Elisa , Rossi Alessandra , Scaltriti Sara , Taliani Erica , Rochira Vincenzo , Simoni Manuela , Carani Cesare

Objective: Aromatase, the key enzyme involved in estrogen synthesis, is expressed in a variety of cells and tissues including human peripheral blood leukocytes (PBLs). The present study was designed to evaluate PBL aromatase gene expression in male and female elderly subjects compared to young male controls.Design: CYP19A1 mRNA and protein were measured in PBLs obtained from young men (n=13) aged < 35 years, postmenopausal women (n</...

ea0020p484 | Obesity and Metabolism | ECE2009

Non-diabetic metabolic syndrome and obesity do not affect serum paraoxonase-1, HDL-paraoxonase and arylestherase activities but affects oxidative stress and inflamation

Tabur Suzan , Nur Torun Ayse , Sabuncu Tevfik , Nuri Turan Mehmet , Riza Ocak Ali , Celik Hakim

Paraoxonase is a high-density lipoprotein-bound antioxidant enzyme that inhibits atherosclerosis. Metabolic syndrome is a combination of several metabolic abnormalities and known to be related with increased cardiovascular events. The most important component of metabolic syndrome which have impact on oxidative stress is diabetes, the most severe form of disturbed carbohydrate metabolism. The effect of metabolic syndrome on oxidative stress and paroxonase-1 (PON-1) activity ha...

ea0020p485 | Obesity and Metabolism | ECE2009

Carotid IMT values are related to insulin resistance and visceral disposition of adiposity in obese patients

Sirbu Anca , Nicolae Horia , Arbanas Tudor , Gologan Serban , Barbu Carmen , Reghina Aura , Lenghen Claudia , Fica Simona

The aim of our study was to assess the relation between common carotid intima-media thickness, a marker of subclinical atherosclerosis and other metabolic risk factors, in a group of obese patients.Patients and methods: Of 142 obese patients (47 male, 95 female, mean age 39.74±11.41 years, and mean BMI 46.88±8.85 kg/m2) were clinically and biologically evaluated. BMI and waist circumference were measured and a complete patient histor...

ea0020p486 | Obesity and Metabolism | ECE2009

The effect of weight loss on serum mannose binding lectin levels

Hoeyem Pernille H , Bruun Jens M , Pedersen Steen B , Richelsen Bjoern , Christiansen Jens S , Hansen Troels K

Background: High levels of mannose-binding lectin (MBL), an activator of complement, have been associated with increased mortality and risk of albuminuria in patients with type 2 diabetes. It is not known if MBL is synthesized in human adipose tissue and the effects of weight loss and changes in insulin sensitivity on MBL levels have been poorly elucidated.Methods: Of 36 nondiabetic obese subjects received a very low-calorie diet (VLCD) of 800 kcal/day f...

ea0020p487 | Obesity and Metabolism | ECE2009

Insulin resistance and anemia markers

Gorar Suheyla , Culha Cavit , Demir Y Selim , Serter Rustu , Aral Yalcin

Aim: In our study, in regard with the women cases of obesity, we have aimed at determining the correlation that existed among the anemia markers, insulin resistance (IR) and fact of Metabolic syndrome (MetS).Method: We have conducted our assessment 67 women who had resorted to our clinic due to their obesity complaints and were in the premenopausal and mean age 36.7±8.8 years. We have put forward the demographic data and measured the biochemical (fa...

ea0020p488 | Obesity and Metabolism | ECE2009

Vasomotor dysfunction and alterations of adipokines in metabolic syndrome patients with insulin resistance

Tretjakovs Peteris , Jurka Antra , Bormane Inga , Reihmane Dace , Mikelsone Indra , Balode Liga , Aivars Juris , Pirags Valdis

Aim: To evaluate relationships between adipokines (adiponectin, resistin, leptin, interleukin-6, tumor necrosis factor-alpha), insulin resistance and cutaneous vasomotor responses in metabolic syndrome (MS) patients with insulin resistance. MS patients with insulin resistance were divided into two groups: 18 patients with type-2 diabetes mellitus (without insulin therapy and pronounced diabetic complications) (DM) and 18 patients without DM. Of 18 healthy subjects were selecte...

ea0020p489 | Obesity and Metabolism | ECE2009

Effect of pharmaceutical intervention on serum levels of advanced glycated end products in women with polycystic ovary syndrome

Diamanti-Kandarakis Evanthia , Christakou Charikleia , Piperi Chistina , Kandaraki Eleni , Katsikis Ilias , Adamopoulos Christos , Papavasiliou Athanasios G , Panidis Dimitrios

Background: Polycystic ovary syndrome (PCOS) is associated with obesity and insulin resistance, two major contributors to cardiovascular risk. Even in the absence of detectable insulin resistance, lean, non-diabetic PCOS women demonstrate increased circulating levels of advanced glycated end products (AGEs), known proatherogenic molecules. This adverse cardiovascular risk profile should be considered in the syndrome’s management.Objective: To invest...

ea0020p490 | Obesity and Metabolism | ECE2009

Insulin-resistance and abnormal glycaemia characterize the metabolic syndrome of polycystic ovary syndrome but not of matched controls

Radian Serban , Mihaila Valentina Raluca , Botusan Ileana , Baculescu Nicoleta , Gheorghiu Monica , Fica Simona , Grigorescu Florin , Coculescu Mihail

Background: The incidence of metabolic syndrome (MetS) is higher in polycystic ovary syndrome (PCOS) patients than in the general population. However, it is still unclear if MetS is qualitatively different in PCOS.Aim: To compare the distribution of MetS diagnostic criteria and of insulin-resistance in subjects with MetS (PCOS versus matched controls).Patients: Of 97 patients with PCOS (Rotterdam criteria) and 31 age- and BMI-match...

ea0020p491 | Obesity and Metabolism | ECE2009

Regulation of novel metabolic regulator fibroblast growth factor-21 by body adiposity and hypercortisolemia: studies in patients with obesity and Cushing’s syndrome

Durovcova Viktoria , Krsek Michal , Hana Vaclav , Marek Josef , Bartlova Marketa , Kavalkova Petra , Haluzik Martin

Fibroblast growth factor-21 (FGF-21) is a novel regulator of metabolic homeostasis that improved diabetes compensation and dyslipidemia in diabetic mice and monkeys. However, little is known about its regulation in humans. Cushing’s syndrome (CS) is characterized by endogenous hypercortisolism and is often associated with numerous metabolic abnormalities. The objective of this study was to test the hypothesis that CS is associated with altered levels of FGF 21 that may in...

ea0020p492 | Obesity and Metabolism | ECE2009

The influence of weight lose on immune system

Yazici Mahmut , Engin Gok Deniz , Pekel Aysel , Tapan Serkan , Sonmez Yusuf Alper , Musabak Ugur , Bolu Sinasi Erol , Kutlu Mustafa

Aim: The prevalence of overweight and obesity is increasing and becoming a global health problem. Obesity is the cause of increased cardiovascular morbidity and mortality and psychosocial problems. There are several reports which mentioning the unfavourable effects of aggressive weight loss regimes on the immune system. This study was designed to search for the effect of a straightforward, controlled and permanent weight loss program on the immune system.<p class="abstext"...

ea0020p493 | Obesity and Metabolism | ECE2009

Plasma levels of uric acid in the patients with fatty liver

Akcay Gungor , Akcay Mufide Nuran

Backgraound: The liver occupies a central position in lipid metabolism. Free fatty acids (FFAs) are taken up by the liver to join the hepatic pool of FFA, a portion of which the liver synthesizes. Fatty liver occurs when lipid accumulation exceeds the normal 5% of liver weight. In the macrovesicular type, large fat droplets balloon the liver cell, displacing the nucleus to the periphery of the cell, like an adipocyte. Triglyceride accumulates most commonly because it has the h...

ea0020p494 | Obesity and Metabolism | ECE2009

The atherogenic index in the fatty liver

Akcay Gungor , Akcay Mufide Nuran

Backgraound: Fatty liver can relate with arteriosclerosis. We investigated the atherogenic index in the patients with fatty liver.Methods: Ninety-one patients with hyperlipidemia and 47 healthy subjects were included in the study. Fasting plasma levels of lipids were detected. Liver echogenity was measured by 3.75 mHz ultrasound probe and was graded by comparison with renal paranchymal echogenity. Atherogenic index was calculated as the ratio of plasma l...

ea0020p495 | Obesity and Metabolism | ECE2009

Energy and nutrients intake among overweight/obese school children in Tehran

Amini Maryam , Dadkhah Monireh

Introduction: Overweight and obesity are being emerged as one of the most prevalent nutritional problems among children in developed and developing countries. To decrease the rate of them there is need to know more about effective factors.Objective: This study aimed to determine association between energy and nutrients intake with overweight / obesity in male and female school children of Tehran.Methods: A sample of 761 school stud...

ea0020p496 | Obesity and Metabolism | ECE2009

Influence of finasteride treatment on metabolic profile of men with androgenetic alopecia

Duskova Michaela , Hill Martin , Starka Luboslav

Androgenetic alopecia, not only caused psychological distress, but also is the risk factor of cardiovascular diseases, glucose metabolism disorders, benign prostate hyperplasia and prostate carcinoma and suspected to present the sign of male equivalent of polycystic ovary syndrome. Finasteride, used for treatment of androgenetic alopecia in dose of 1 mg/day, is the first 5α-reductase type II inhibitor. The 5α-reductase is enzyme responsible for the reduction of testo...

ea0020p497 | Obesity and Metabolism | ECE2009

Prevalence of hypo- and hypermagnesemia in an urban population

Siadmoradi Leila , Ghasemi Asghar , Zahedi Asl Saleh , Azizi Fereidoun

Background: Magnesium is the fourth most abundant action in the body and plays an important role in metabolic processes. Association between magnesium deficiency and clinical condition including hypertension, diabetes, insulin resistance, hyperlipidemia, and atherosclerosis. Although magnesium deficiency is associated with a variety of medical conditions, the prevalence of hypo- and hypermagnesemia have not been reported in general population.Methods: Th...

ea0020p498 | Obesity and Metabolism | ECE2009

The effect of α-lipoic acid on myostatin and myosin heavy chain isoform profile of skeletal muscle of OLETF rats

Yoo Soon Jib , Hong Oak Kee , Kim Do Man , Kwon Hyuk Sang , Son Ho Young , Kang Sung Koo , Kim Dong-Sun

Aims: To investigate the mechanism of α-lipoic acid (ALA) on preventing diabetes, we evaluated the effect of ALA on growth regulation and composition of skeletal muscle.Methods: OLETF and LETO rats, aged 24 weeks, were treated with or without ALA (100 mg/kg body weight/day in drinking water) and / or insulin (insulin glargine, 2 U/kg body weight/day; subcutaneous injection) for 8 weeks.Results: The treatment of ALA with or wit...

ea0020p499 | Obesity and Metabolism | ECE2009

Comparing the activity of orlistat and sibutramine on obesity treatment

Sahin Ibrahim , Keskin Lezzan , Comert Melda

Introduction: In this study, we aimed to examine the weight alterations after the medical treatment and compare the effects of medical treatment in obese patients who applied to Endocrinology Policlinic.Material and method: We examined the patients who were diagnosed as obesity and initiated medical treatment at Endocrinology and Metabolism Diseases Policlinic in Inonu University Medical Faculty between Agust 2005–May 2008. Patients were divided int...

ea0020p500 | Obesity and Metabolism | ECE2009

Normal metabolic flexibility despite insulin resistance in lean and obese women with polycystic ovary syndrome

Straczkowski Marek , Kowalska Irina , Adamska Agnieszka , Karczewska-Kupczewska Monika , Nikolajuk Agnieszka , Lebkowska Agnieszka , Gorska Maria

Polycystic ovary syndrome (PCOS) is heterogeneous disorder, where insulin resistance might be involved in the development of endocrine and metabolic abnormalities. Insulin resistance is associated with the so-called metabolic inflexibility i.e. an impaired switch from lipid to glucose in response to insulin. The aim of the present study was to estimate glucose and lipid oxidation, metabolic flexibility and non-oxidative glucose metabolism in lean and obese PCOS patients.<p...

ea0020p501 | Obesity and Metabolism | ECE2009

Lipid levels in anorexia nervosa patients

Nikolic-Djurovic Marina , Pekic Sandra , Miljic Dragana , Doknic Mirjana , Petakov Milan , Stojanovic Marko , Popovic Vera

Anorexia nervosa (AN) is a chronic disorder characterized of profound reduction in body weight and amenorrhoea. Despite emaciation and avoidance of cholesterol-rich food, hypercholesterolaemia is a common feature. The aim of the study was to investigate the changes in lipid metabolism with weight gain in 17 severe AN patients aged 23.8±1.6 years (DSM-IV criteria). They were compared with age-matched cohorts of 11 healthy controls (22.5±3.9 years) before and after wei...

ea0020p502 | Obesity and Metabolism | ECE2009

Prevalence of the metabolic syndrome in men with late-diagnosed Klinefelter syndrome

Gusakova Daria , Kalinchenko Svetlana , Mskhalaya George , Tishova Yuliya

Introduction: Klinefelter syndrome (KS) is the most common sex-chromosome disorder with a prevalence of 1 in every 660 men, but only 25% of the expected number of patients are diagnosed. It is also one of the most common endocrine disorders, and takes the third place after diabetes mellitus and thyroid gland diseases. KS is one of the most frequent causes of hypogonadism in men. It is known that hypogonadism in men has been found to be an independent risk factor for developmen...

ea0020p503 | Obesity and Metabolism | ECE2009

Metabolically healthy but obese individuals

Mesquita Joana , Souto Selma , Varela Ana , Freitas Paula , Matos Maria Joao , Ferreira Miguel , Correia Flora , Braga Daniel , Carvalho Davide , Medina Jose Luis

Introduction: Obesity is a heterogenous disorder. One of its subtypes that has been recently described is termed the metabolically healthy, but obese (MHO) individuals. Preliminary evidence suggests that this could be due to lower visceral fat levels and earlier onset of obesity.Objectives: To determine the prevalence of MHO in a sample of obese patients. To evaluate whether body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) are...

ea0020p504 | Obesity and Metabolism | ECE2009

Effects of stress on kidney: a histochemical study on rat model

Demirci Tuba , Ozbek Elvan

Objective: Stress, which is seen prevalently among people, causes a general situation of tension via damaging the balance of the body. During stress, it is known that, at the first, central systems, like nerve system, heart and blood circulation system, nutritive system, genital systems and adrenalin tissues are also affected. In this study, kidney was histopathologically examined on the rat model in order to investigate how and in what level the kidneys are affected from the ...

ea0020p505 | Obesity and Metabolism | ECE2009

Anthropometric parameters and non alcoholic hepatic steatosis in type 2 diabetes

Hachmi Leila Ben Salem , Bouzid Chiraz , Farhat Leila Ben , Dorai Azza , Waghlani Ridha , Hendaoui Lotfi , Slama Claude Ben

Aim: The aim of the study was to assess the association between anthropometric parameters and non alcoholic hepatic steatosis in type 2 diabetes.Methods: Computed tomography imaging was used to assess hepatic fat content in 80 men and women with type 2 diabetes. Inclusion criteria included a confirmed diagnosis of type 2 diabetes (≥1 year of duration), without history of hepatic disease or daily consumption of alcohol drink. Clinical and biochemica...