Endocrine Abstracts (2009) 20 P345

Evaluation of coronary artery disorders in diabetic patients with no or atypical cardiac symptoms

Rasoul Zakavi1,2, Haleh Rokni1,2, Zohreh Mousavi1,2, Mahdi Taherpour1,2, Reza Rajabian1,2 & Mohamad Khajeh Dalooei1,2


1Mashad Medical Science University, Mashad, Islamic Republic of Iran; 2Razavi Hospital, Mashad, Islamic Republic of Iran.


Introduction: Coronary artery disorder has been featured as the leading cause of dead in diabetics. This study was designed to assess the prevalence of silent myocardial ischemia in asymptomatic patients with diabetes.

Methods and patients: One hundred and thirty asymptomatic type 2 diabetic patients were enrolled in the study. A questioner was filled including patients’ demographic information and routin laboratory tests. HsCRP was measured for all patients. All patients underwent transtorasic echocardiography Exercise test was done for those without prolifrative retinopathy and severe degenerative joint disease. Patients with positive or strongly positive ETT were directly referred for angiography. Gated myocardial perfusion SPECT was performed in 108 patients with negative or mild positive ETT.

Results: The mean age of the patients was 51.8±7.3 years and the mean weight was 72.9±9.6 kg and average abdominal circumference and BMI was 94.9±9.3 and 27.9±9.8 respectively. The mean time interval since diabetes diagnosis was 7.8 years. Total number of 43 patients had silent ischemia according to ETT and GSPECT findings. Two patients (1.5%) had positive ETT and 10 patients (17.7%) had strongly positive ETT. GSPECT revealed ischemia in 31 patients. The size of ischemia was small in most patients. Traditional and emerging risk factors werenot significantly different between patients with or without ischemia.

Conclusion: Silent ischemia was relatively prevalent among our patients. Traditional and emerging risk factors were not able to predict silent ischemia. Designing a new guideline for earlier screening of diabetic patients seems to be helpful.

Keywords: Cronary artery disease, Diabetes, Cardiac symptoms.

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