Impaired glucose tolerance (IGT) and metabolic syndrome (MS) is considered as the pre-diabetic stages. Recently, it has been suggested that inflammation is associated with the components of MS and it may also have a role in the development of type 2 Diabetes Mellitus (DM). The aim of this study was to investigate the effects of inflammation in the pathogenesis of DM.
The study groups consisted of 51 patients with type 2 DM, 28 patients with MS, and 26 patients with IGT. DM patients had either initial diagnosis or recent history with the ultimate period of 5 years. A total of 21 healthy person was included as the control group. Highly sensitive CRP (hsCRP), fibrinogen, ferritin and white cells were utilized as the markers for inflammation. The relationships between the inflammation markers and parameters of MS were investigated in all groups.
The levels of hsCRP and fibrinogen were significantly higher in DM, IGT, and MS than control group. The level of hsCRP was highest in the DM group. On the other hand, ferritin was found to be higher in the DM group than the controls. When the whole study group was considered, hsCRP had positive correlations with WC, insulin, BMI, TG, HOMA, postprandial glucose (PPG), fasting blood glucose (FBG), cholesterol, LDL, and a negative correlation with HDL.
In conclusion result of the current study suggests that inflammation parameters particularly elevated levels of hsCRP were strongly associated with DM and features of MS.
25 - 29 Apr 2009
European Society of Endocrinology