Endocrine Abstracts (2009) 20 P467

Plasma monocyte chemoattractant protein-1 and macrophage inflammatory protein-1[alpha] are increased in patients with polycystic ovary syndrome and associated with adiposity, but unaffected by pioglitazone treatment

Dorte Glintborg1, Marianne Andersen1, Bjørn Richelsen2 & Jens Bruun2

1Department of Endocrinology, Odense University Hospital, Odense, Denmark; 2Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Aarhus, Denmark.

Objective: PCOS patients are often characterized by insulin resistance, abdominal obesity, and low-grade inflammation. Insulin sensitizing treatment reduces the inflammatory state, but the effect on serum levels of chemokines such as migration inhibitor factor (MIF), monocyte chemoattractant protein (MCP)-1, and macrophage inflammatory protein (MIP)-1α have not previously been evaluated in PCOS.

Research design and methods: Plasma chemokine levels (MCP-1, MIP-1α, and MIF) were measured in two study designs. 1) 51 hirsute patients and 63 matched controls and 2) 30 PCOS patients before and after randomized treatment with 30 mg pioglitazone/placebo for 16 weeks. Clinical evaluations and whole body DXA-scans were performed in all participants.

Results: Hirsute patients (n=51) had significantly increased MCP-1 (121 (15–950) vs 81 (18–365) pg/ml; P<0.05) and MIP-1α (179 (8–4202) vs 103 (4–1598) pg/ml; P<0.05) than controls of matched body composition (geometric mean (−2 to +2S.D.)). In PCOS (n=30), MCP-1, MIP-1α, and MIF correlated positively with central fat mass. A BMI independent positive association was found between MIF-1 and free testosterone (r=0.49, P=0.01) in PCOS.

Pioglitazone treatment significantly improved insulin sensitivity without affecting testosterone, body composition, MCP-1, MIP-1α, and MIF levels.

Conclusions: Chemokine levels were significantly increased and showed close associations with measures of adiposity in PCOS patients, but were unchanged during insulin sensitizing treatment with pioglitazone. Our data suggests a fat mass independent association between testosterone and MIF-1 levels in PCOS and the effect of antiandrogen treatment on chemokine levels needs to be examined.

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