ECE2009 Poster Presentations Reproduction (50 abstracts)
Influence of polycystic ovary syndrome and obesity on vascular parameters (common carotid artery intima-media thickness – CCA-IMT, common carotid artery compliance – CP-CCA and endothelium function of the brachial artery – FMD) related to the process of atherosclerosis
Jose Marcondes 1 , Cristiano Barcellos 1 , Sylvia Lage 1, , Angela Romano 1, , Michele Rocha 1 , Sylvia Hayashida 1, , Daniela Curi 1, & Edmund Baracat 1,
1Endocrine Unit, Hospital das Clinicas, Sao PAuo, SP, Brazil; 2Gynecological Unit, Hospital das CLinicas, Sao PAulo, SP, Brazil; 3Itensive Care Unit, Instituto do Coracao, Sao Paulo, SP, Brazil.
In order to determine the influence of PCOS and obesity on vascular parameters, we studied 25 patients with PCOS (10 with normal body mass index – BMI – and 15 obese) without classic cardiovascular risk factors (IGT or DM, arterial hypertension, dyslipidemia) and 23 control women (12 with normal BMI and 11 obese), pairwise matched for BMI, through a non-invasive method using high resolution ultrasound imaging. Global age range was 26.0±4.7 years. The mean values of free testosterone in PCOS patients were significantly higher than the means in controls, independently of BMI. The means of HOMA-IR and the area under the curve for insulin in obese PCOS patients were significantly higher than the ones observed in PCOS patients with normal BMI and Controls. The groups were formed according to the presence or absence of PCOS and obesity – PCOS group (n=25) versus Control group (n=23), independently of BMI and normal BMI (n=22) versus obesity group (n=26), independently of PCOS presence. The means of CCA-IMT was higher in PCOS group than in Control group (49.1±1.0 vs 47.2±1.0 mm.10−2, P<0.05) and similar between normal BMI and Obesity groups (49.1±1.0 vs 47.3±1.0 mm.10−2, P=NS). It was not observe any influence in CP-CCA in PCOS group vs Control group (1.9±0.1 vs 1.7±0.1 N−1.m4.10−10, P=NS) and in normal BMI vs Obesity group (1.7±0.1 vs 1.9±0.1 N−1.m4.10−10, P=NS) as well as in FMD in PCOS group vs Control group (6.8±1.1 vs 9.3±1.1%, P=NS) and in normal BMI vs Obesity group (88.3±1.1 vs 7.8±1.1%, P=NS). In conclusion, in young women without cardiovascular risk factors, the presence of PCOS had influence on the increase of CCA-IMT. Thus, CCA-IMT might be the initial marker of the atherosclerosis process in these groups of patients.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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