Endocrine Abstracts (2009) 20 P118

Demographic, clinical, laboratory, ultrasonographic and cytological features of patients with Hashimoto's thyroiditis: results of a university hospital of 769 patients in Turkey

Mehmet Erdogan1, Nihat Erdem2, Sevki Cetinkalp1, Gokhan Ozgen1, Fusun Saygili1, Candeger Yilmaz1, Mehmet Tuzun1 & Taylan Kabalak1


1Department of Endocrinology and Metabolism, Ege University Faculty of Medicine, Izmir, Turkey; 2Department of Internal Medicine, Ege University, Izmir, Turkey.


Background: We investigated the demographic and clinical features of patients with Hashimoto’s thyroiditis who had been diagnosed and treated in Ege University, the main referral center in the Aegean region of Turkey.

Methods: Medical records of patients who had been followed in the endocrinology clinic of Ege University were retrospectively evaluated. Patients who had been diagnosed as having any thyroid disorder were determined. Patients with Hashimoto’s thyroiditis were selected among those patients.

Results: Seven hundred and sixty-nine patients fulfilled diagnostic criteria for Hashimoto’s thyroiditis (725 females, 44 males; mean age 41.76±12.49 years). 62.7% of patients were between 30–50 years of age. 53.3% of females and 63.6% of males had diffuse enlargement of the thyroid gland. TSH level was above 4.0 IU/l in 25.6% of females, and 27.4% of males. Anti-tyroglobulin antibody was positive in 92% of females, and 93.2% of males. Anti-thyroid peroxydase antibody was positive in 98.4% of females (713 patients), and 100% of males. Thyroid ultrasonography demonstrated single nodule in 52.2% and multiple nodules in 11.3% of female patients; and single nodule 32% and multiple nodules in 20% of male patients. Fine-needle aspirations of the nodules were performed in 207 patients, and none of those biopsies were diagnosed as malignant.

Conclusion: Age and sex distribution and laboratory findings of our patients were comparable to the previous reports. Nodule formation was the most common ultrasonographic finding in our patients, probably due to pseudonodularity. We found no patient with thyroid cancer in our population.