Thyroid disease let to change of weight in hyperthyroid body mass is reduced, but in hypothyroid it is increased. Recently researches suggest that many new bioactive substances, like ghrelin and obestatin, play a role in regulation of body mass. These closely related hormones have paradoxically different effects- ghrelin increases, but obestatin decreases appetite. The aim of the study was to evaluate ghrelin and obestatin levels in young patients with untreated Graves disease, subclinical Hashimoto thyroiditis and in children with struma nodosa in euthyroid clinical state. The study group formed 78 patients suffering from Graves disease (29 girls and 2 boys; aged from 6 to 21- mean 15.2 yrs) and Hashimotos thyroiditis (29 girls and 3 boys; aged from 9 to 18- mean 14.5 yrs). The control group consisted of children with struma nodosa (in euthyrosis) 13 girls and 2 boys; aged from 9 to 18 mean 14.8 yrs. In all patients were performed ghrelin and obestatin levels RIAs method (firmy Phoenix Pharmaceuticals, USA). In children and adolescents with hyperthyroid in Graves disease we found lower levels of ghrelin compared to group of children with struma nodosa and with subclinical hypothyroid in Hashimotos thyroiditis (123±23 vs 151±36; vs 140±45 pg/ml, P<0.02, NS). On the other hand obestatin levels was lower in children with untreated subclinical hypothyroid in Hashimotos thyroiditis compared to group with struma nodosa or Hashimotos thyroiditis in euthyroid (203.28±49 vs 222.49±59; 267.24±67 P<0.03, P<0.02). In group of untreated hyperthyroid in Graves disease we found relationship between ghrelin and fT3 (r=−0.36, P<0.4) and fT4 levels (r=−0.45, P<0.01).
Conclusions: The disturbances in thyroid hormones in thyroid diseases have an essential effect on changes of hormones controlled appetite: ghrelin (in hyperthyroid) and obestatin (in hypothyroid).
25 - 29 Apr 2009
European Society of Endocrinology