Objective: It was previously shown that primary hyperparathyroidism (PHPT) might induce impaired renal function and chronic renal failure. The aim of our study was to evaluate the effect of surgical treatment on parameters of calcium and phosphate renal metabolism and renal function in patients with PHPT.
Material and methods: In 26 patients with PHPT (age: 57.15±9.54 years, BMI 26.00±4.55 kg/m2, PTH 276.61±64.83 ng/l, Calcium 2.95±0.19 mmol/l) serum creatinine, urine calcium levels, phosphate (CPH) and creatinine clearance (CCR), tubular phosphate reabsorption (TRP), proteinuria and microalbuminuria were determinated before and 4 months after surgical treatment. Paired t-test and Wilcoxon test were used for statistical analysis, as well Pearson correlation test. Statistical analysis.
Results: After operation PTH (51.47±8.57 ng/l) and serum calcium (2.33±0.12 mmol/l) were normalized There was significant improvement in urine calcium levels (398.37±181.2 vs 107.07±53.41 mg/day, P<0.05), CPH (22.27±11.67 vs 12.41±5.24 ml/min, P<0.05) and TRP (70.55±10.56 vs 82.31±11.37, P>0.05) after surgical treatment. There was no change in serum creatinine (87.90±30.71 vs 91.76±27.90, P>0.05) and CCR (78.02±38.83 vs 80.19±30.71, P>0.05). There was nonsignificant reduction in proteinuria (131.78±32.84 vs 111.68±27.79 mg/day, P>0.05) and microalbuminuria (54.07±21.14 vs 39.60±15.05 mg/day) after operation. There was significant negative correlation between serum calcium levels and CCR (r=−0.492, P<0.05).
Conclusion: Radical treatment improves parameters of calcium and phosphate renal metabolism and renal function in patients with PHPT.