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Endocrine Abstracts (2009) 20 P265

Institute of Endocrinology, Diabetes and Diseases of Metabolism, Belgrade, Serbia.

Objective: It was previously shown that patients with primary hyperparathyroidism (PHPT) have atherogenic dyslipidaemia. The aim of our study was to evaluate the effect of surgical treatment on lipid levels in patients with PHPT.

Material and methods: In 26 patients with PHPT (age: 57.15±9.54 years, BMI 26.00±4.55 kg/m2, PTH 276.61±64.83 ng/l, Calcium 2.95±0.19 mmol/l) Total cholesterol (TC), HDL-C, LDL-C, triglyceride (TG), ApoA1, ApoA2, ApoB, ApoE and Lp(a) levels were determinated before and after surgical treatment. Paired t-test and Wilcoxon test were used for statistical analysis, as well Pearson correlation test. Statistical analysis.

Results: After operation PTH (51.47±8.57 ng/l) and serum calcium (2.33±0.12 mmol/l) were normalized, there was no change in BMI index before and after operation (26.00±4.55 vs 26.36±4.31 kg/m2, P>0.05). There was increase in ApoE levels (46.20±11.46 vs 57.49±13.86, P<0.05) after operation. There was no change in TC (6.02±1.33 vs 6.00±1.11 mmol/l, P>0.05), HDL-C (1.26±0.32 vs 1.28±0.30, P>0.05), LDL-C (3.84±1.07 vs 3.94±1.01, P>0.05), TG (1.78±0.76 vs 2.04±0.97, P>0.05), Apo A1 (1.637±0.305 vs 1.627±0.302, P>0.05), Apo B (1.165±0.276 vs 1.145±0.325), Apo A2 (288.57±56.42 vs 305.08±52.56, P>0.05) and Lp(a) (0.19±0.05 vs 0.16±0.04, P>0.05) after operation. There was significant correlation between PTH and Lp(a) levels (r=0.534, P<0.05). CONCLUSION, radical treatment did not improve dyslipidemia in our group of patients with PHPT.

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