Endocrine Abstracts (2009) 20 P266

Vitamin D levels in young healtly premenopausal females in Slovakia

P Vanuga1, Z Killinger2, P Masaryk3, S Tomkova4, Z Kmecova5, V Spustova6, A Stecova7 & J Payer2


1Osteocentre, National Institute of Endocrinology and Diabetology, Lubochna, Slovakia; 25th Clinic of Internal Medicine, Faculty Hospital of Comenius University, Bratislava, Slovakia; 3National Institute of Rheumatic Diseases, Piestany, Slovakia; 4Osteocentre, Kosice, Slovakia; 5Osteocentre, FD Roosevelt Faculty Hospital, Banska Bystrica, Slovakia; 6Clinic of Pharmacotherapy, Slovak Medical University, Bratislava, Slovakia; 7Department of Laboratory Medicine, Medirex, Bratislava, Slovakia.


Background: There is increasing body of evidence suggesting for low vitamin D levels in humans. The levels of vitamin D in nonselect populations of Europe, Middle East, Asia and Latin America had been repeatedly shown to be as low as 20-30 μg/l.

Aim: The aim of our study was to examine serum 25-hydroxyvitamin D [25-(OH)D] levels in young healthy premenopausal women in Slovak population.

Subjects and methods: The participants (n=162, mean age 34.0 years), regularly cycling, fertile females with normal BMD and no risk factors of osteoporosis were recruited in six centres. The blood procedures were performed during one month (October 2007), after highest exposure to sunlight in our region. Serum 25-(OH)D levels were measured by HPLC method (Shimadzu, Chromsystem).

Results: The mean 25-(OH)D levels were 32.6 μg/l (min. 6.7 μg/l, max. 69.5 μg/l). In females at the age of 25–40 years, tendency to decrease of 25-(OH)D levels with increasing age was observed. Up to 80 (49.4%) subjects had their 25-(OH)D levels lower than 30 μg/l, the level generally accepted as the lower limit of normal for 25-(OH)D.

Conclusions: In conclusion, the prevalence of low 25-(OH)D concentration in healthy young female in Slovakia is very high and general vitamin D supplementation in our population should be considered.

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