Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2009) 20 P299


1Chair and Department of Endocrinology, Medical College, Jagiellonian University, Krakow, Poland; 2Department of Gastrointestinal Surgery, Medical College, Jagiellonian University, Krakow, Poland; 3Endocrine Surgery, Medical College, Jagiellonian University, Krakow, Poland; 4Department of Endoscopic Surgery, Medical College, Jagiellonian University, Krakow, Poland; 5Department of CNS Neoplasms, Oncology Centre, Warszawa, Poland.

Neuroendocrine tumours (NETs) are rare neoplasm arising from dispersed endocrine system. Their incidence is estimated to be five cases per 100 000 population, although the true incidence may be higher as the consequence of often oligosymptomatic course of disease and indolent behaviour of NETs. The most typical localization of NETs is gastrointestinal tract and bronchi. However they may develop in every organ of the body containing neuroendocrine cells. The diagnosis of NET is usually made based on symptoms related to (1) the endocrine functuion of the tumour and the type of the secreted biologically active molecules and (2) local invasion. NETs of atypical presentation are most often found because of the local symptoms or incidentally. The possibility that type of the tumour is the distant metastasis of the more common type of NETs should always be considered. Iit is obligatory in every case of rare NET (including rare localization within gastrointestinal tract, i.e. gallbladder or Meckel’s diverticulum) to search for other possible primary lesion, particularly by scintigraphic methods. The aim of the study is to present NETs of rare localization from the material of The Chair and Department of the Endocrinology, CM UJ. In NET database of Chair and Department of Endocrinology of the Medical College of the Jagiellonian Univeristy, comprising 244 patients mostly from south-eastern part of Poland, 11 tumours of unusual origin has been registered so far. They are: 4 NET of Vater’s ampulla, 2 NET of gall bladder, 1 NET of Meckel’s diverticulum, 1 ovarian NET, 1 epiglottic NET, 1 thymic NET and 1 NET arising from sphenoid sinus. All of them were diagnosed because of the local symptoms. Early excision of the lesion resulted in achieving disease regression. Based on that cases descriptions authors will discuss diagnostic and therapeutic pathway in NETs of rare localization.

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