Association studies between genetic variants of adiponectin gene and susceptibility to type 2 diabetes (T2D) and increased body mass index (BMI) have provided contradictory results. We selected 10 SNPs (rs2241767, rs1501299, rs3777261, rs16861210, rs2241766, rs822396, rs182052, rs17300539, rs16861194, rs266729) in promoter and coding regions of adiponectin gene based on haploblock structure and previously reported association studies. Selected SNPs were screened in 170 patients with T2D and 665 controls from Genome Data Base of Latvian Population. Neither of polymorphisms were associated with T2D status when analyzed using logistic regression and adjusted for gender, age and other significant covariates. Similarly, none of analyzed variants displayed significant allelic differences in BMI levels as assessed by linear regression with correction for significant cofactors. In addition correlation between allelic frequencies of all SNP and other diseases present in cohort of individuals selected for study was analyzed. Two polymorphisms were associated with presence of acute myocardial infarction (rs1501299, P=0.004; rs3777261, P=0.034). These associations, however, lost their significance when adjusted for multiple testing. In summary, we conclude that SNPs in adiponectin gene are unlikely to represent the risk for T2D and increased BMI in Latvian population.
25 - 29 Apr 2009
European Society of Endocrinology