Endocrine Abstracts (2009) 20 P370

The relationship between body mass index-left ventricle mass index-myocardial performance index in type 2 diabetes

Fatma Alibaz Oner1,2, Zeynep Gurcan1,2, Isil Uzunhasan1,2, Mehmet Emin Piskinpasa1,2 & Mecdi Erguney1,2

1Istanbul Education and Research Hospital, Istanbul, Turkey; 2Cardiology Institute of Haseki, University of Istanbul, Istanbul, Turkey.

Introduction: Diabetes mellitus (DM) has been associated with abnormalities of cardiac function and left ventricular hypertrophy. Diabetic individuals, particularly women, had higher heart rates, greater left ventricular wall thicknesses, greater cardiac mass than unaffected subjects. We aimed to investigate association between waist circumference–body mass index (BMI) and left ventricle mass (LVM)-left ventricle mass index (LVMI), left ventricle myocardial perfusion index (MPI) in patients with type 2 DM and without known cardiac disease.

Methods: The patients with type 2 DM were examined with tissue doppler imaging echocardiography to detect MPI.LVM was calculated by the Penn Convention formula.

LVMI was calculated. Waist circumference was measured, BMI was calculated. The exclusion criterias; known cardiac diseases, pulmonary diseases, endocrine diseases except DM, anemia, angina pectoris, dyspnea, peripheral edema, serum creatinine level>1.5 mg/dl, ejection fraction (EF)<50%. The GraphPad Prisma V.3 package program was used for statistical analyses.

Results: A total of 42 patients, men (40.5%) and women (59.5%) aged 37–57 years were included. In all patients, there were significant correlations between waist circumference and LVM; between BMI and LVM; between BMI and LVMI. Looking at the results according to sex; there were significant relations between BMI and LVM (P: 0, r: 0.685), BMI and LVMI (P: 0.007, r: 0.528) in women. This parameters were not associated in men. There was significant correlation between BMI and MPI (P: 0.026, r: −0.537) in only men (Table 1).

Conclusion: BMI associated with increasing LVM and LVMI, is an important risk factor in expecially women for diabetic heart disease. The MPI, a new doppler index of global cardiac function, has limited importance in type 2 diabetes without clinical cardiac disease and is more important in men.

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