Endocrine Abstracts (2009) 20 P371

Correlation between serum 25 hydroxy vitamin D3 and laboratory risk markers of cardiovascular diseases in type 2 diabetic patients

Shokoufeh Bonakdaran & Abdol-Reza Varasteh

Medical Sciences, Mashhad, Islamic Republic of Iran.

Background: Vitamin D deficiency is prevalent worldwide. Low 25 hydroxyvitamin D3 concentration inversely associate with type 2 diabetes, metabolic syndrome, insulin resistance, and probably cardiovascular disease. The objective was the evaluation of association between vitamin D deficiency and cardiovascular risk factors among some diabetic patients.

Methods and materials: One hundred and nineteen type 2 diabetic patients in IRAN from December to March 2008 were used. Coronary, cerebrovascular and peripheral vascular diseases were confirmed by medical history review, examination and paraclinical tests. Blood biochemical parameters including laboratory risk markers of cardiovascular disease were determined by standard laboratory procedures. Serum 25 (OH) D was measured during winter. The correlation between vitamin D deficiency and cardiovascular prevalent and also laboratory variables was determined.

Results: Mean patients age was 55.3±11.2 year. The mean 25 (OH) D concentration was 32.4±21.6 ng/ml. Prevalence of hypovitaminous D was 26.1% among the diabetic patients. The difference with control group was not significant (P=0.12). In overall, 36 (30.3%) patients were positive for coronary vascular disease (CVD). The correlation between hypovitaminous D and CVD was not significant (P=0.11). Vitamin D deficiency had a significant relationship with body mass index (P=0.003), metabolic syndrome(P=0.05), high sensitive CRP (P=0.009), microalbuminuria (P=0.04), and glumerolar filtration rate (P=0.02). FBS, HbA1C, lipid profiles, homocysteine, uric acid and insulin resistance was not related to vitamin D deficiency.

Conclusion: The results showed a correlation between hypovitaminous D and inflammatory markers that could be contributed in cardiovascular disease so vitamin D may be important in cardiovascular health.

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