Objective: To determine the frequency of diabetic retinopathy in prediabetik individuals and to evaluate the relevant factors.
Materials and methods: A total of 118 persons between 20 and 60 years of age attending our internal medicine clinic between January 2006 and March 2008 were recruited for the study. The exclusion criterions were the presence of diabetes mellitus and use of antidiabetic agents. Fasting blood glucose between 100 and 125 mg/dl was defined as impaired fasting glucose (IFG); blood glucose after 2 h oral glucose tolerance test between 140 and 199 mg/dl was defined as impaired glucose tolerance (IGT). The individuals provided these criterions were included the study. In addition, diabetic history, physical examination (tension arteriale, pulse, fever) and laboratory investigations (creatinine, ALT, AST, Total cholesterole, HDL-C, triglyceride versus LDL-C) were carried out.
Results: Hypertension was found in 27.1% of participants and retinopathy was determined in 11% of them. The frequency of retinopathy in patients with isolated IFG, isolated IGT and both IFG and IGT were 2, 9.1 and 22.2%, respectively. The frequency of hypertension were found to be 15.7, 36.4 and 35.6%, respectively. There are significant correlations between retinopathy and postglucose 2 h blood glucose (PG2hr BG) (P: 0,001, r: 296), the presence of isolated IGT (P: 0.006, r: 252), coexistence of IFG and IGT (P: 0.002, r: 281). In logistic regression analyse, statistically significant parameters for retinopathy according to impotance are as follows: (1) coexistence of IFG and IGT (P: 0.002), (2) PG2hr BG (P: 0.003), (3) presence of isolated IGT (P: 0.006). Although HbA1C was no statistically significant for retinopathy, it was in fourth line as predictive (P: 0.073).
Conclusion: In our study, frequency of retinopathy among prediabetic subjects were significantly higher in group of coexisting IFG and IGT than other groups. Additionally, PG2hr BG was the most important predictor of retinopathy.
25 - 29 Apr 2009
European Society of Endocrinology