It has been shown that women with previous GDM more likely developed metabolic syndrome (MS). This study aimed to determine predictors of the later development of MS in women with previous GDM.
One hundred sixty-four consecutive women with previous GDM were evaluated after a mean follow-up of 40.54 months from index pregnancy. Sixty-five lean women with negative screening for GDM were included as a control group. Data regarding antenatal and peripartum characteristic of participants were collected prospectively. Subjects were evaluated for the diagnosis of MS according to criteria of NCEPATP III and IDF. Tests were performed including 75 g. OGTT, fasting insulin, lipids, plasma fibrinogen, blood pressure, and body measurements. HOMA score was calculated.
MS prevalence was higher in women with previous GDM according to both definitions. Women with previous GDM were more overweight and insulin resistant. They had more atherogenic lipid profile and increased fibrinogen levels. Univariate analysis showed that prepregnancy obesity, weight gain during follow-up and fasting glucose level at the OGTT of the index pregnancy were predictors of developing MS. Multivariate analysis showed that fasting glucose level >100 mg/dl at the OGTT of the index pregnancy was an independent predictor of the MS development.
We suggest that early prediction of women with previous GDM who are at high risk for developing MS is possible, and it is vital to prevent MS related complications.
25 - 29 Apr 2009
European Society of Endocrinology