Endocrine Abstracts (2009) 20 P430

Exercise induced oxidative stress in type 2 diabetes: relation to diastolic dysfunction and hypertension

Nada Kostic

School of Medicine, Clinic for Internal Medicine, Clinical Hospital Center Dr Dragisa Misovic, Univerisity of Belgrade, Belgrade, Serbia.

Background: Lipid peroxidation and antioxidant systems are important factors affecting the oxidation of lipoproteins. Left ventricular dysfunction and hypertension are much more common in subjects with type 2 diabetes mellitus and limit exercise performance.

Aims: The aim of our study was to evaluate the oxidative stress in patients with diabetes mellitus type 2 and to determine influence of acute exercise training on the investigated parameters.

Methods: To asses’ oxidative stress of the patients, we determined the following parameters: total cholesterol, low density cholesterol, Ox LDL cholesterol, superoxide dismutase, glutathione peroxidase, plasminogen activator-type 1 which was measured at rest and immediately after the acute bout of cardiopulmonary exercise cycle ergometer test.

Results: In basal condition, diabetic patients have significant increase of Ox LDL cholesterol and SOD enzyme activity compared to controls. During acute exercise test, there were significantly greater levels of Ox LDL in study patients and in control group. SOD significantly increases in both groups during exercise, in diabetic patients and in controls. GSH-Px was significantly increased only in diabetic patients after acute exercise. Type 2 diabetic patients with cardiovascular complications have only significant increase of GSH-Px activity.

Conclusion: Elevated OxLDL, SOD and GSH-Px levels are associated with exercise in type 2 diabetic patients.

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